1,721,022 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Learning Disabilities and Behaviour in Neurofibromatosis Type 1 Patients
No full textNeurofibromatosis type 1 is well known for its physical manifestations but learning and behavioural impairments are in fact a significant cause of morbidity. The last two decades has seen a great increase in research into understanding the neuropsychological phenotype of NF1 and great strides are being made into discovering treatments for these impairments based on this understanding. Although there is wide variability in the psychological and behavioural phenotype, there are a number of core features that have been identified. The aim of this chapter is to summarise the current knowledge and research in this area
Moleculaire en functionele karakterisatie van een nieuw neuro-cardio-faciaal-cutaan syndroom: Legius syndroom
No full textWe beschreven en karakteriseerden een nieuwe autosomaal dominante aandoening, Legius syndroom, die genetisch verschillend is maar klinisch erg gelijkend op neurofibromatose type 1 (NF1). De klinische kenmerken bestaan uit café-au-lait vlekken met of zonder sproeten, macrocefalie, een relatief kleine gestalte en een verhoogde frequentie van leerproblemen bij kinderen. Sommige patiënten vertonen Noonan-gelijkende dysmorfe karakteristieken en sommige individuen vervullen de klinisch diagnostische NIH criteria voor NF1. Sommige typische NF1-geassocieerde kenmerken zijn systematisch afwezig, zoals Lisch nodules, neurofibromen, NF1-geassocieerde botdefecten en tumoren van het centrale zenuwstelsel. Inactiverende mutaties werden geïdentificeerd in SPRED1, dit gen codeert voor een eiwit dat de RAS-MAPK signaaltransductie cascade negatief reguleert en dit ter hoogte van RAS-RAF interactie. Melanocyten van een café-au-lait vlek van een aangetast individu vertoonden biallelische mutaties in SPRED1 (kiemlijn en somatische SPRED1 mutatie). Deze aandoening is een nieuw lid van de groep van de fenotypisch overlappende neuro-cardio-faciale-cutane (NCFC) syndromen of RASopathieën. Een grote groep van NF1-mutatie negatieve patiënten werd onderzocht en in 1.9% van de patiënten werd een pathogene SPRED1 mutatie geïdentificeerd. In een klein percentage van de gevallen werd een SPRED1 missense mutatie gevonden en functioneel gekarakteriseerd naar pathogeniciteit. We toonden aan dat sommige van deze SPRED1 missense mutaties effectief pathogeen zijn. Omdat leerproblemen gerapporteerd werden bij verscheidene kinderen met Legius syndroom, werd een muis Spred1-/- model gebruikt om zowel hippocampaal afhankelijk leren en geheugen als lange termijn potentiatie te onderzoeken. Spred1-/- muizen vertoonden een verlaagde performantie in de gedragstesten wat leren en geheugen betreft en korte en lange termijn hippocampale synaptische plasticiteitsdefecten werden geobserveerd. We startten een verkennende studie omtrent het Spred Drosophila "loss-of-function" model, omdat dit uiterst geschikt is als screen voor interagerende proteïnen, betrokken celtypes en signaaltransductie cascades. We detecteerden een subtiel groeidefect met een kleinere vleugelgrootte maar met een normaal venenpatroon. We identificeerden verminderde opschrik geïnduceerde locomotie en verminderd agressief gedrag in de Spred "loss-of-function" vliegen. Larvale neuromusculaire juncties vertoonden een verminderd aantal synapsen (boutons) in de Spred-/- vliegen, hoewel de lengte en spier innervatie niet veranderd was. Deze succesvolle initiële verkennende studie in Drosophila toonde verschillende fenotypes aan en laat ons toe om in de toekomst Spred functie en proteïne interacties in dit model te bestuderen.status: Publishe
Neurofibromatose type 1-gerelateerde pseudoartrose
No full textNeurofibromatosis type 1 (NF1) is an autosomal dominant disorder with aprevalence of 1 in 2000. About 5% of NF1 patients present with (congenital) bowing of a long bone resulting in pseudarthrosis, usually unilaterally. In most cases the congenital pseudarthrosis (PA) affects the tibia and the pathogenesis of this condition is currently unknown.
Diverse treatment options for the NF1-related PA are available. Individuals with NF1 are however susceptible to recurrent fractures and if bridging of the CPA remains elusive or recurrent fractures occur, amputation of the affected limb is oftentimes the only option.
To gain more insight into the pathogenesis underlying NF1-related PA, we studied pseudarthrosis cells and periosteum cells of the affected limb for their NF1 status and also studied the functional effect of NF1 inactivation on these cells. Furthermore, we attempted to model the genetics of NF1-related PA in mouse models, this was however not successfull.status: Publishe
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