170,483 research outputs found
Integrace procedurálního kódu do proudových paralelních systémů
No full textTitle: Procedural code integration in streaming environments Author: Mgr. Michal Brabec Department: Department of Software Engineering Supervisor: David Bednárek, Ph.D. Abstract: Streaming environments and similar parallel platforms are widely used in image, signal, or general data processing as means of achieving high perfor- mance. Unfortunately, they are often associated with domain specific program- ming languages, and thus hardly accessible for non-experts. In this work, we present a framework for transformation of a procedural code to a streaming ap- plication. We selected a restricted version of the C# language as the interface for our system, because it is widely taught and many programmers are familiar with it. This approach will allow creating streaming applications or their parts using a widely known imperative language instead of the intricate languages specific to streaming. The transformation process is based on the Hybrid Flow Graph - a novel inter- mediate code which employs the streaming paradigm and can be further convert- ed into streaming applications. The intermediate code shares the features and limitations of the streaming environments, while representing the applications without platform specific technical details, which allows us to use well known graph algorithms to work with the...Název práce: Integrace procedurálního kódu do proudových paralelních systémů Autor: Mgr. Michal Brabec Katedra: Katedra softwarového inženýrství Vedoucí disertační práce: David Bednárek, Ph.D. Abstrakt: Datově orientované paralelní systémy představují vhodnou platfor- mu pro optimalizaci datově intenzivních aplikací, jako jsou například databázové dotazy. Hlavní problém těchto systémů je komplikovaná architektura a specifické programovací jazyky, které ztěžují návrh aplikací pro programátory bez kom- plexní znalosti celého systému. V této práci prezentujeme systém, který umožňuje návrh proudových aplikací v omezené verzi jazyka C#, který je známý většině programátorů a často s ním dovedou pracovat i výzkumníci ostatních vědeckých oborů. Náš systém umožňuje vývoj proudových aplikací i jejich částí bez znalosti specifických paralelních jazyků a architektury paralelního systému. Jádrem naší práce je formalismus Hybrid Flow Graph, který náš systém používá pro reprezentaci aplikace ve formě blízké proudovým systémům. Hlavní výhoda tohoto přístupu je, že aplikace jsou reprezentovány v mezikódu, který má vlast- nosti podobné cílovému prostředí, ale neobsahuje specifické technické detaily. Díky...Department of Software EngineeringKatedra softwarového inženýrstvíMatematicko-fyzikální fakultaFaculty of Mathematics and Physic
Procedural code integration in streaming environments
No full textTitle: Procedural code integration in streaming environments Author: Mgr. Michal Brabec Department: Department of Software Engineering Supervisor: David Bednárek, Ph.D. Abstract: Streaming environments and similar parallel platforms are widely used in image, signal, or general data processing as means of achieving high perfor- mance. Unfortunately, they are often associated with domain specific program- ming languages, and thus hardly accessible for non-experts. In this work, we present a framework for transformation of a procedural code to a streaming ap- plication. We selected a restricted version of the C# language as the interface for our system, because it is widely taught and many programmers are familiar with it. This approach will allow creating streaming applications or their parts using a widely known imperative language instead of the intricate languages specific to streaming. The transformation process is based on the Hybrid Flow Graph - a novel inter- mediate code which employs the streaming paradigm and can be further convert- ed into streaming applications. The intermediate code shares the features and limitations of the streaming environments, while representing the applications without platform specific technical details, which allows us to use well known graph algorithms to work with the..
Gangesia mukutmanipurensis Marick & Brabec & Choudhury & Scholz & Ash 2023, SP. NOV.
No full textGANGESIA MUKUTMANIPURENSIS SP. NOV. (FIGS 4–6) Z o o B a n k r e g i s t r a t i o n: u r n: l s i d: z o o b a n k. org:act: 142F33C8-72A5-4BDA-AEAE-B2F0DBAB5413 Description Based on 16 specimens from Ompok bimaculatus from West Bengal, India, including three scoleces observed using SEM: strobila more than 158 mm long (N = 3), with acraspedote proglottids, up to 1.96 mm wide (N = 3), consisting of more than 143 proglottids (N = 3): 40– 94 immature (up to appearance of spermatozoa in vas deferens), four to five mature (up to appearance of eggs in uterus), 67–74 pregravid (up to appearance of hooks in oncospheres) and gravid. Proglottids variable in shape, usually slightly wider than long in mature and pregravid and longer than wide in gravid towards terminal end; mature proglottids 575–1038 (733) long by 725–1413 (990) wide, L/W = 0.43–1.59 (0.79) (N = 18). Inner longitudinal musculature well-developed, anastomosed, forming isolated bundles of muscle fibres (Fig. 4C, D). Subtegumental muscles well-developed (Fig. 4C, D). Osmoregulatory canals running alongside vitelline follicles. Ventral osmoregulatory canals thin-walled, width representing 4–7% of width of mature proglottids, overlapping lateral-most testes, form anastomoses in some proglottids. Dorsal osmoregulatory canal narrow, thick-walled, prominent in immature proglottids but gradually disintegrating with maturation of proglottids, not observable in gravid proglottids, canal may reach lateral-most testes (Figs 4A, B, 5E). Scolex wider than neck, 134–203 (157) long by 144–203 wide (169) (N = 7). Rostellum-like organ 34–61 (51) long and 53–89 (71) wide, devoid of hooks. Suckers four, uniloculate, devoid of hooklets on rims (Figs 5A–C, 6A, B), 59–89 (76) in diameter (N = 17); R/S = 0.75–1.14 (0.93), R/X = 0.35–0.50 (0.41). Prominent retractor muscle bundles surrounding rostellum-like organ, joining at level of suckers, forming a wide band of muscles (retractors) in neck region (Fig. 5B–D). Rostellum-like organ covered with capilliform filitriches (Fig. 6C–G), apical part additionally armed with several rows of large, coniform spinitriches (Fig. 6A–C, H). Suckers also covered with capilliform filitriches, rim of suckers with coniform spinitriches that are smaller than those on rostellum (Fig. 6D–F). Surface of scolex between suckers bearing interspersed gladiate spinitriches (Fig. 6I). Proliferative zone 4.7–7.2 mm long and 333–416 wide (N = 2). Neck region covered with gladiate spinitriches. Testes medullary, in single field, spherical to oval, 31–81 (50) in diameter (N = 115), numbering 82–144 (109) (N = 28), mostly forming single layer (Figs 4A, B, 5E), occupying 65–80% of length of proglottids. Cirrus-sac elongate, thick-walled, 163–269 (199) long by 63–88 (74) wide [N = 17; L/W = 2.0–3.7 (2.7)]; C/P = 17–26% (20%), i.e. 1/6–1/4 of width of proglottids. Genital pore irregularly alternating, pre-equatorial, situated at 23–40% (32%) (N = 13) of length of proglottids from anterior margin (Figs 4A, B, 5E). Ovary medullary, 175–338 (228) long, 400–913 (640) wide (N = 18), occupying 26–38% (31%) of length of proglottid, bilobed, each lobe spherical to rectangular (Figs 3A, B, 4E); O/P = 55–71% (65%) (N = 18). Mehlis’ gland 81–113 (96) in diameter (N = 8), representing 8–11% of width of proglottid. Vagina thick-walled, posterior (58%) or anterior (42%, N = 100) to cirrus-sac, with higher concentration of chromophilic cells in its distal (terminal) part; ring-like vaginal sphincter present near genital atrium (Figs 4A, B, 5E, F). Vitelline follicles oval, medullary, some follicles paramuscular (between muscle fibres of inner longitudinal musculature to cortex) (Fig. 4C, D), present in two longitudinal bands on lateral margin of proglottid, occupying 77–91% (86%) of length of proglottid on poral side, 85–96% (92%) on aporal side in mature proglottids (N = 17); bands interrupted at level of terminal genitalia on ventral side, with few follicles on dorsal side in more than half of mature and pregravid proglottids bands mostly interrupted (92%), both dorsally and ventrally in gravid proglottids (Figs 4A, B, 5E, F). Uterus medullary, with type 1 development (sensu de Chambrier et al., 2004). In pregravid proglottids, lateral diverticula thin-walled, 17–23 (20) in number on each side (N = 18), occupying up to 58% of proglottid width, may partly overlap ovary (Fig. 4A, B). Uterus with uterine pores; uterine pores four to seven in number (N = 18), slit-like (Figs 4A, 5E). Eggs with hyaline, spherical outer envelope, 41–61 (50) in diameter (measured in eggs liberated from uterus in distilled water; N = 15); oncosphere spherical, 13–19 (16) in diameter, with three pairs of embryonic hooks, eight to 8–11 (9) long (N = 30), diameter with embryophore 20–30 (26); embryophore 2–5 (3) thick, consisting of two layers, outer layer thinner than nucleated inner envelope (Fig. 5G). Taxonomic summary Ty p e h o s t: O m p o k b i m a c u l a t u s (B l o c h, 1 7 9 4) (Siluriformes: Siluridae). Site of infection: Intestine (anterior part). Type locality: Mukutmanipur Dam Lake, Bankura, West Bengal, India (22°57’48"N, 86°47’18"E). PreƲalence and intensity of infection: Prevalence 9.5% (20 of 211 Ompok bimaculatus examined); mean intensity 1.8 (one to four worms/host) (see Table 2). Specimens deposited: Holotype and hologenophore ZSI/W11082/1/1–ZSI/W11083/1/2. Paratypes: HWML-216818; IPCAS C-913/1; MHNG-PLAT-0067053; ZSI/W11084/1, ZSI/W11085/1, ZSI/W11086/1, ZSI/W11087/1, ZSI/W11088/1, ZSI/W11089/1. Genetic data: lsr DNA gene sequence (partial) (GenBank accession numbers) ON181446, ON181456, ON181457 and COI gene sequence (partial) (GenBank accession numbers) ON176195. Hologenophores: MHNG-PLAT- 0067053; ZSI / W 11087 /1, ZSI / W11082/1/1–ZSI/W11083/1/2. Etymology: The species name is derived from the Mukutmanipur Dam Lake, the type locality of this parasite. Remarks: The new species is a member of Gangesia because it possesses characteristics that include: (1) presence of prominent retractor muscles that form a wide band; (2) rostellum-like organ longer than, or as long, as the size of suckers; (3) ventral osmoregulatory canals median (internal) to vitelline follicles; (4) testes in single field; (5) vagina posterior or anterior to the cirrus-sac; (6) lateral band of vitelline follicles occupying almost the total length of the proglottid; and (7) type 1 uterine development (sensu de Chambrier et al., 2004) (see ‘Generic composition and interrelationship in the Gangesiinae’ in the Discussion for details). The new species differs from all eight congeners by the absence of hooks on the rostellum-like organ and hooklets on the anterior rim of suckers, previously considered to be the most typical feature of the genus. Instead of hooks and hooklets, several rows of coniform spinitriches are present on the rostellum-like organ and the anterior rim of the suckers. Along with this unique scolex morphology, the new species is also typified by a narrow rostellum-like organ (less than 90 µm wide) and indistinguishable dorsal osmoregulatory canals in pregravid and gravid proglottids.Published as part of Marick, Jit, Brabec, Jan, Choudhury, Anindo, Scholz, Tomáš & Ash, Anirban, 2023, The evolution of an ancient tapeworm lineage in its catfish hosts: vicariance, dispersal and diversification in Gangesiinae (Cestoda: Proteocephalidae), pp. 509-533 in Zoological Journal of the Linnean Society 198 on pages 516-522, DOI: 10.1093/zoolinnean/zlac098, http://zenodo.org/record/798159
Activation of platinum(IV) prodrugs by cytochrome c and characterization of the protein binding sites
No full textPlatinum(IV) complexes generally require reduction to reactive Pt(II) species to exert their chemotherapeutic activity. The process of reductive activation of 15N-labeled (OC-6-43)-bis(acetato)diamminedichloridoplatinum(IV), in the presence of nicotinamide adenine dinucleotide (NADH) and horse heart cytochrome c (cyt c), was monitored by 1H,15N-HSQC NMR spectroscopy and protein digestion experiments. It has been shown that cyt c plays a catalytic role in the transfer of two reducing equivalents from NADH to Pt(IV) species. Noncovalent interactions between reduced monoaqua cisplatin (cis-[PtCl(15NH3)2(H2O)]+) and the protein, in the proximity of the heme cofactor, and also covalent binding of platinum to the protein region around Met65 and Met80 take place
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
AMČR - let C-LET-00274
No full textLetiště - start: Praha-LetňanyLetiště - cíl: Praha-LetňanyÚčel letu: Další pozorovatelé: Brabec (MMP). Navigátor: Gojda. Podmínky letu: vegetace. Teplota: 22 (st.). 2 dny bez srážek. Viditelné situace: viditelné struktury; historická architektura; stavební akce.Počasí: oblačnoDohlednost: 70–80 k
Time domain investigation of the intrachain vibrational dynamics of a prototypical light-emitting conjugated polymer
No full text
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
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