1,720,970 research outputs found
Postsurgical pain related to breast implant: reduction with lipofilling procedure
No full textAfter a review of clinical cases of the Unit of Plastic Surgery of the University of Siena, Italy, we found that 22 patients undergoing lipofilling for breast recontruction needed less pain drugs compared to 18 patients which did not undergo lipofilling. In this work, the postoperative pain was analyzed in two groups of patients: a cohort treated with prosthesis and a cohort treated with prosthesis implant together with a lipofilling procedure
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Novel potential determinants in endoplasmic reticulum stress, inflammation and insulin resistance: Apo CIII and sAPPβ
Get PDFDiabetes represents one of the biggest health challenges of the 21st century. Insulin resistance is the primary defect in the most common form of diabetes, type 2 diabetes mellitus (T2D), and is defined as a failure in the capacity of insulin to drive glucose into its target tissues. This condition both predicts and precedes the development of T2D.
Loss of insulin sensitivity in skeletal muscle is the major defect in T2D and is believed to be critical in the pathogenesis of this disease. Elucidating new molecular mechanisms involved in insulin resistance in skeletal muscle may lead to the development of new strategies for the prevention and treatment of T2D.
Insulin resistance develops as the result of the expansion of adipose tissue in obese individuals, which releases increased amounts of fatty acids, hormones, pro-inflammatory cytokines and other factors. Most of these molecules induce the activation of a chronic low-level inflammatory process that contributes to insulin resistance and T2D. The molecular mechanisms by which these molecules induce a low-grade and chronic inflammatory process in obese patients are not completely understood. However, some studies have shown that alterations in the endoplasmic reticulum (ER) might contribute to the development of an inflammatory status and consequently to insulin resistance.
Obesity and insulin resistance are also characterized by the presence of atherogenic dyslipidemia, which refers to elevated levels of triglycerides (TG) and the particles responsible for carrying these lipids in the plasma, the very low-density lipoproteins (VLDL), low levels of high-density lipoproteins (HDL), and increased levels of small, dense low-density lipoproteins (sdLDL). In addition to TG, VLDL also contain apolipoproteins, of which apolipoprotein CIII (Apo CIII) is one of the most abundant. Although plasma levels of VLDL and Apo CIII are increased in diabetic patients, little was known about whether the increase in the levels of these lipoproteins and apolipoproteins contributes to exacerbate insulin resistance and the mechanisms involved.
Recent evidence indicates that subjects suffering T2D are at higher risk of developing Alzheimer’s Disease (AD). In addition, several evidences point out that the converse is also true, since cognitive impairment and Alzheimer’s dementia can induce central and peripheral insulin resistance, thus increasing the risk of T2D.
The β-site Amyloid precursor protein Cleaving Enzyme 1 (BACE1) or β-secretase is a key enzyme involved in AD and is responsible for the cleavage of Amyloid Precursor Protein in the amyloidogenic pathway. It has been recently reported that BACE1 is also implicated in glucose metabolism. Thus, BACE1-deficient mice are protected against high fat diet (HFD)-induced glucose intolerance and inhibition of BACE1 activity increases insulin-independent glucose uptake. BACE1 is proteolytically active not only in the brain but also in skeletal muscle, suggesting that this enzyme might be involved in development of systemic insulin resistance. However, little was known about whether BACE1 contributes to ER stress, inflammation and insulin resistance.
In this thesis, we report that the increase in the levels of VLDL can promote ER stress, inflammation, and insulin resistance in skeletal muscle through Apo CIII-mediated activation of the toll-like receptor 2.
Moreover, BACE1 inhibition in myotubes results in an improvement in lipid-induced ER stress, inflammation, and insulin resistance. Further, the product of BACE1 enzymatic activity, soluble amyloid precursor protein β (sAPPβ), mimics the effects of palmitate and induces ER stress, inflammation and insulin resistance.
Overall, these findings suggest that both VLDL-Apo CIII and sAPPβ are new determinants involved in ER stress, inflammation and insulin resistance in skeletal muscle
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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