1,720,959 research outputs found
Liposomal Formulations of Metallodrugs for Cancer Therapy
Full text linkThe search for new antineoplastic agents is imperative, as cancer remains one of the most
preeminent causes of death worldwide. Since the discovery of the therapeutic potential of cisplatin,
the study of metallodrugs in cancer chemotherapy acquired increasing interest. Starting from cisplatin
derivatives, such as oxaliplatin and carboplatin, in the last years, different compounds were explored,
employing different metal centers such as iron, ruthenium, gold, and palladium. Nonetheless,
metallodrugs face several drawbacks, such as low water solubility, rapid clearance, and possible side
toxicity. Encapsulation has emerged as a promising strategy to overcome these issues, providing both
improved biocompatibility and protection of the payload from possible degradation in the biological
environment. In this respect, liposomes, which are spherical vesicles characterized by an aqueous
core surrounded by lipid bilayers, have proven to be ideal candidates due to their versatility. In
fact, they can encapsulate both hydrophilic and hydrophobic drugs, are biocompatible, and their
properties can be tuned to improve the selective delivery to tumour sites exploiting both passive
and active targeting. In this review, we report the most recent findings on liposomal formulations of
metallodrugs, with a focus on encapsulation techniques and the obtained biological results
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Synthesis of Gold(I) and Palladium(II) Complexes Bearing N‐Heterocyclic Carbene Thioglucosides with Selective Cytotoxicity Towards Ovarian Cancer Cells
Full text linkWe report the development of an efficient and versatile synthetic protocol for the preparation of gold(I) and palladium(II) complexes bearing N-heterocyclic carbene (NHC) thioglucosides and their azolium precursors. Gold(I) and Nolan-type palladium(II)-allyl complexes were synthesized under mild aerobic conditions using potassium carbonate as a base. Additionally, allyl palladate complexes were prepared via a straightforward solvent-free method. In vitro assays on three ovarian cancer cell lines (OVCAR-5, A2780, and its cisplatin-resistant clone A2780cis) revealed interesting structure-activity relationships (SARs). Gold(I) complexes with saturated NHC ligands showed enhanced activity, while Nolan-type palladium(II)-allyl complexes with unsaturated NHC ligands exhibited higher efficacy. Allyl palladates demonstrated similar activity regardless of whether the ligand was saturated or not. The most promising compounds display high selectivity for cancer cells, with cytotoxicity comparable to cisplatin on A2780 and OVCAR-5 lines and superior activity against the A2780cis line. Notably, these compounds showed minimal toxicity towards non-cancerous MRC-5 cells. This selective anticancer activity is likely due to the presence of glucoside units, suggesting their role as targeting agents
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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