49,953 research outputs found
Avere cura della professionalità dell’insegnante: un uso formativo e riflessivo degli strumenti quantitativi di valutazione della pratica e del contesto lavorativo.
No full textP a r t e n d o d a u n a r i c o g n i z i o n e
sull’autovalutazione delle scuole e da un
costrutto di professionalità docente, il contributo
intende mostrare due strumenti di lavoro utili per
la valutazione della pratica professionale e la
misurazione delle percezioni del contesto di
lavoro. Lo studio è un approfondimento di una
ricerca più ampia sulla professionalità del
docente. Lo scopo è indagare come le
percezioni del contesto di lavoro, indagate
tramite un riadattamento per la scuola del
Management Standard Indicator Tool (HSE,
2004) influiscono sulla professionalità
dell’insegnante, indagata tramite il questionario
Quin (Lucisano & Botta, 2023). Viene mostrata la
reportistica fornita alle scuole partecipanti utile
per definire, nella loro autonomia e particolarità
di contesto, azioni e strategie d’intervento.
Inoltre, viene illustrato l’uso dei risultati per la
c o m p i l a z i o n e d e l R AV n e l l e s e z i o n i
Orientamento strategico e organizzazione della
scuola e Sviluppo e valorizzazione delle risorse
umane
Avere cura della professionalità dell’insegnante: un uso formativo e riflessivo degli strumenti quantitativi di valutazione della pratica e del contesto lavorativo
No full textP a r t e n d o d a u n a r i c o g n i z i o n e
sull’autovalutazione delle scuole e da un
costrutto di professionalità docente, il contributo
intende mostrare due strumenti di lavoro utili per
la valutazione della pratica professionale e la
misurazione delle percezioni del contesto di
lavoro. Lo studio è un approfondimento di una
ricerca più ampia sulla professionalità del
docente. Lo scopo è indagare come le
percezioni del contesto di lavoro, indagate
tramite un riadattamento per la scuola del
Management Standard Indicator Tool (HSE,
2004) influiscono sulla professionalità
dell’insegnante, indagata tramite il questionario
Quin (Lucisano & Botta, 2023). Viene mostrata la
reportistica fornita alle scuole partecipanti utile
per definire, nella loro autonomia e particolarità
di contesto, azioni e strategie d’intervento.
Inoltre, viene illustrato l’uso dei risultati per la
c o m p i l a z i o n e d e l R AV n e l l e s e z i o n i
Orientamento strategico e organizzazione della
scuola e Sviluppo e valorizzazione delle risorse
umane
Pyrazolo [3,4-d] pyrimidines c-Src inhibitors reduce epidermal growth factor-induced migration in prostate cancer cells
No full textDuring its biological progression, prostate cancer frequently develops dependence on growth factor receptors and their downstream signalling messengers, including c-Src. Evidence for this supports the choice of c-Src as a therapeutic target in the prevention of tumour spreading. Two new pyrazolo[3,4-d]pyrimidines c-Src inhibitors, SI35 and SI40, were used to investigate the role of c-Src in the control of the aggressive phenotype of prostate carcinoma cell line, PC3. SI molecules reduced the proliferation of PC3 cells in a time- and dose-dependent manner, with an IC50 of approximately 50 microM. PC3 cells responded to the presence of epidermal growth factor (EGF) by increasing their migratory ability, and this effect was strongly reduced by the addition of SI at concentrations less than IC50. Further observations demonstrated that SI molecules modulated cell morphology and their adhesive capacity on different physiological substrates. The action of SI molecules appeared to involve, in parallel with c-Src inhibition, the down-modulation of the active forms of paxillin and extracellular signal-regulated kinase (ERK). Our data suggest a promising role for pyrazolo[3,4-d]pyrimidines c-Src inhibitors in the control of a highly invasive tumour phenotype
EVIDENCE OF A NEW STATE AT SIMILAR-TO-1660-MEV/C(2) OBSERVED IN NP-ANNIHILATIONS
No full textA study of up in-night annihilations is presented. The 4 pi invariant mass spectrum resulting from the analysis of the five-prong exclusive events, following the annihilation of similar to(100-297) MeV/c ($) over bar n, reveals, besides a large structure centred at similar to 1500 MeV/c(2), some evidences for a new state around 1660 MeV/c(2). RI Galli, Domenico/A-1606-2012; Iazzi, Felice/F-4490-2012; Botta, Elena/G-9742-2012; Villa, Mauro/C-9883-2009; Fontana, Andrea/I-4375-2012; Filippi, Alessandra/I-9530-201
STRUCTURE AND CONFORMATION OF STEREOISOMERIC C-ISOPROPOXYCARBONYLMETHYLCALIX[4]RESORCINARENES
No full textTreatment of (E)-2,4-dimethoxycinnamic acid isopropyl esters with boron trifluoride-diethyl ether in chloroform at room temperature affords various stereoisomeric C-alkylcalix[4]resorcinarenes, which differ in their conformations; the crystal structures of two stereoisomers have been determined and compared with geometries resulting from theoretical calculations
Evolution of the G+C content frontier in the rat cytomegalovirus genome
No full textWithin the 230138 bp of the rat cytomegalovirus (RCMV) genome, the G+C content changes abruptly at position 142644, constituting a G+C content frontier. To the left of this point, overall G+C content is 69.2%, and to the right it is only 47.6%. A region of extremely low G+C content (33.8%) is found in the 5 kb immediately to the right of the frontier, in which there are no predicted coding sequences. To the right of position 147501, the G+C content rises and predicted coding sequences reappear. However, these genes are much shorter (average 848bp, 50% G+C) than those in the left two-thirds of the genome (average 1462bp, 70% G+C). Whole genome alignment of several viruses indicates that the initial ultra-low G+C region appeared in the common ancestor of the genera Cytomegalovirus and Muromegalovirus, and that the lowering of G+C in the right third has been a subsequent process in the lineage leading to RCMV. The left two-thirds of RCMV has stop codon occurrences at 67.5% of their expected level, based on a modified Markov chain model of stop codon distribution, and the corresponding figure for the right third is 78%. Therefore, despite heavy mutation pressure, selective constraint has operated in the right third of the RCMV genome to maintain a degree of gene length unusual for such low G+C sequences
Nature of the neutral Na+-Cl- coupled entry at the apical membrane of rabbit gallbladder epithelium: IV. Na+/H+,Cl-/HCO3- double exchange, hydrochlorothiazide-sensitive Na+-Cl- symport and Na+-K+-2Cl- cotransport are all involved
No full textTransepithelial fluid transport was measured gravimetrically in rabbit gallbladder (and net Na+ transport was calculated from it), at 27 degrees C, in HCO(3-)-free bathing media containing 10(-4) M acetazolamide. Whereas luminal 10(-4) M bumetanide or 10(-4) M 4-acetamido-4'-iso-thiocyanostilbene-2,2'-disulfonate (SITS) did not affect fluid absorption, 25 mM SCN- abolished it; hydrochlorothiazide (HCTZ) in the luminal medium reduced fluid absorption from 28.3 +/- 1.6 (n = 21) to 8.6 +/- 1.6 microliters cm-2 hr-1 (n = 10), i.e., to about 30%. This maximum effect was already obtained at 10(-3) M concentration; the apparent IC50 was about 2 x 10(-4) M. The residual fluid absorption, again insensitive to SITS, was completely inhibited by SCN- or bumetanide. Cl- influx at the luminal border of the epithelium, measured under the same conditions and corrected for the extracellular space and paracellular influx, proved insensitive to 10(-4) M bumetanide, but was slowly inhibited by 10(-3) M HCTZ, with maximum inhibition (about 54%) reached after a 10-min treatment; it subsequently rose again, in spite of the presence of HCTZ. However, if the epithelium, treated with HCTZ, was exposed to 10(-4) M bumetanide during the measuring time (45 sec), inhibition was completed and the subsequent rise of Cl- influx eliminated. Intracellular Cl- accumulation with respect to the predicted activity value at equilibrium decreased significantly upon exposure to 10(-3) M HCTZ, reached a minimum within 15-30 min of treatment, then rose again significantly at 60 min. Simultaneous exposure to HCTZ and bumetanide decreased the accumulation to a significantly larger extent as compared to HCTZ alone, already in 15 min, and impeded the subsequent rise. Intracellular K+ activity rose significantly within 30 min treatment with HCTZ; the increase proved bumetanide dependent. The results obtained show that Na(+)-Cl- symport, previously detected under control conditions, is the HCTZ-sensitive type; its inhibition elicits bumetanide-sensitive Na(+)-K(+)-2Cl- cotransport. Thus, the three forms of neutral Na(+)-Cl(-)-coupled transport so far evidenced in epithelia, Na+/H+, Cl-/HCO3- double exchange (in the presence of exogenous bicarbonate), HCTZ-sensitive Na(+)-Cl- symport and bumetanide-sensitive Na(+)-K(+)-2Cl- cotransport, are all present in the apical membrane of rabbit gallbladder
Vascular homografts: Clinical results
No full textThe authors review the results of clinical experiences regarding arterial and venous homografts. For the treatment of mycotic aneurysms and infected prostheses, in situ repair with vascular homografts represents a valuable alternative to conventional surgical treatments. In fact the large caliber arterial homografts allow safe in situ reconstruction, decrease early and midterm mortality and reinfection rates; the best results are achieved in case of infected grafts, whereas the prognosis of vasculo-enteric fistula remains very poor. The small caliber arterial homografts also have demonstrated satisfactory results in term of patency although further experiences with longer follow-up are required. Vein homograft constitutes an alternative by-pass conduit for limb revascularisation in patient who lack adequate autogenous vein: although limb salvage rate is satisfactory long term patency rate is poor when compared with autogenous veins. Improvement of preservation methodics, pharmacological control of rejection and tissue engineering represent thefiture perspectives in this field
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