1,742,721 research outputs found
The impact of genetic data on Medicine and Insurance practice
No full textThe extrordinary progresses achieved over the past decades in the field of human genetics and genomics have undoubtedly identified novel frontiers both in medical research and in clinical practice. Indeed, this innovation has significantly contributed to medical treatment of several human disorders and paved the way to personalized medicine approaches.
At the same time, progresses in human genetics and genomics also raised delicate issues related to the collection and treatment of genetic data and to their use, particularly when one comes to their adoption in medicine and in the insurance field.
Germany has already demonstrated considerable interest in this area by early approaching the field through a regulatory act, the Gendiagnostikgesetz. The discipline contained in the Gendiagnostikgesetz is strongly oriented toward the respect of the basic rights of the human being and of his dignity.
Since discussion about this legislation has more recently started in Italy as well, it seemed appropriate to have a closer look at the existing German statute from a multidisciplinary perspective and draw conclusions from the experiences made and from the criticisms this legislation had to face. This volume assembles the contributions offered by Italian and German senior and junior scholars to an International Workshop, jointly organized in Naples by the Università di Napoli “Federico II” and the Freie Universität Berlin and held in May 2014
Miguel de Cervantes, Don Chisciotte della Mancia, traduzione e note del cap. 13 della II Parte
No full textTraduzione e note del cap. 13 della Seconda Parte del Chisciotte, curata da Patrizia Botta che ne ha affidato la traduzione a "56 ispanisti italiani di fama internazionale, esperti dei testi di Cervantes e conoscitori della lingua spagnola del 600" (Patrizia Botta, Avvertenza, p. IX
"1865, Carlo Botta, un nome per il Liceo"
No full textBiografia di Carlo Botta, esaminata semioticamente, ricostruendo personalità culturale e storica del personaggi
Las fiestas de Zaragoza y las relaciones entre LB1 y 16RE
No full texta firma Botta le pagine 3-31 e 44-5
In Memory of Maurizio Botta: His Contribution to the Development of Computer-Aided Drug Design
Full text linkMaurizio Botta was born in Manziana, near Rome (Italy), on May 1950. He built his background in chemistry at Sapienza University of Rome, and then, he received his Ph.D. in 1979 at the University of Brunswick (Canada) working at the total synthesis of complex natural products under the supervision of Prof. Karel Wiesner. From 1980 to 1987, he was a Researcher at the Sapienza University of Roma, and thanks to a NATO grant, he spent one year in 1985–1986 working as a postdoctoral associate in the group of Prof. Stephen Hanessian at the University of Montreal (Canada), where he was also invited as a visiting scientist many other times thereafter.(1) In 1987, he became an Associate Professor of medicinal chemistry at the University of Siena (Italy) and then a Full Professor in 2000. His scientific career was objectively successful, as he was author in more than 400 papers and books or book chapters, as well as inventor in more than 25 patents. He was a member of many scientific societies and editorial boards of journals mostly devoted to chemistry, medicinal chemistry and drug design. Particularly, he served as an Associate Editor for ACS Medicinal Chemistry Letters.
Besides his chemical background, in his research life Maurizio was intrigued by multiple fields adjacent to synthetic chemistry, such as biochemistry, biophysics, molecular biology, and computational modeling. This latter captured his attention and was implemented in his research activity as a crucial support to drug design since the beginning of the 1990s. It is worth noting that most of Botta’s publications report on the use of computational tools, mostly relying on (but not limited to) molecular mechanics (MM) approaches to rationalize existing biological data, or to drive the design and synthesis of bioactive compounds. His research initially focused on conformational analysis of small molecules with the double aim to seize the enormous possibilities offered by MM in modeling conformational flexibility detected by NMR spectroscopy, as well as to exploit the active analogue approach (AAA) developed by Prof. Garland Marshall to interpreting pharmacological properties of bioactive compounds.(2) Thanks to the fruitful collaboration with Prof. Kosta Steliou (University of Montreal), near the beginning of the 1990s, his group started to use the VAX version of Model software, implemented with the MMX force field that was especially suitable to modeling molecular systems with π-electron delocalization. In the same years, MacroModel was used to model with high accuracy the flexibility of an increased number of organic molecules thanks to different force fields, while the use of Sybyl was initially related to its graphic potential but would later pave the way to using the CoMFA 3D-QSAR methodology. Since then, the role of computational modeling studies became more and more relevant in the research of Maurizio’s group, up to the publication of papers mostly or exclusively conducted at the theoretical level. The crucial role of theoretical approaches in drug design was highlighted by the successful series of workshops, i.e., the European Workshop in Drug Design (EWDD), held every two years in the lovely location of Certosa di Pontignano in the countryside of Siena (Italy).
The aim of this paper is to honor the memory of Prof. Maurizio Botta and to briefly overview the major contributions he gave to the field of computer-aided drug design, chemical information, and modeling. Works that represented a milestone in his research strategy are briefly overviewed herein, grouped on the basis of the topic. Finally, a note to the EWDD series is provided
Cerimonia Posa della "Prima Pietra" del Nuovo Complesso Didattico Progettato dall\u27Arch. Mario Botta
No full textLa cerimonia di posa della prima pietra del nuovo complesso didattico progettato dall\u27Arch. Mario Botta che sorgerà nell\u27area ex Rizzato.Prof. Giuseppe Zaccaria, Magnifico RettoreDigitale a color
Mario Botta per lUniversità. Nuovo polo didattico
No full textE stato presentato, nel corso di una conferenza stampa al Bo, il Progetto del nuovo polo didattico per la Biologia e la Medicina, affidato dallUniversità di Padova allarchitetto Mario Botta. Si conferma così la volontà dellAteneo di commissionare a nomi di chiara fama e prestigio internazionale la progettazione degli edifici destinati alle attività di didattica e ricerca. Il complesso si situa nella superficie ex-Rizzato, lungo via Venezia, nella nuova area dellUniversità tra via Pescarotto, via Maroncelli verso la Stanga a Padova Est. Alla conferenza stampa hanno preso parte, insieme allArch. Botta, il Magnifico Rettore Vincenzo Milanesi, il Direttore Amministrativo Giuseppe Barbieri e il Sindaco di Padova Flavio Zanonato. «Far crescere nella città unedilizia universitaria di qualità è per noi un dovere culturale» ha sottolineato nelloccasione il Magnifico Rettore.Botta (primo a sinistra): famoso architetto svizzero; Milanesi: Rettore; Zanonato: sindaco di Padova; Barbieri: direttore amministrativo dell\u27UniversitàDigitale a color
Cerimonia Posa della "Prima Pietra" del Nuovo Complesso Didattico Progettato dall\u27Arch. Mario Botta
No full textLa cerimonia di posa della prima pietra del nuovo complesso didattico progettato dall\u27Arch. Mario Botta che sorgerà nell\u27area ex Rizzato.Prof. Giuseppe Zaccaria, Magnifico RettoreDigitale a color
Botta espone Botta
No full textRecensione della mostra "Mario Botta. Architetture 1960-2010", Rovereto, Mart, 25 gennsettembre 2010 - 23 gennaio 2011. A otto anni dall'inaugurazione del Mart, Mario Botta, autore del progetto insieme all'ingegnere Giulio Andreolli, torna a Rovereto con una grande retrospettiva dedicata alla sua opera: una introduzione con libri, riferimenti e memorie, e dodici sezioni per raccontare quasi cinquant'anni di architettura, attraverso schizzi e disegni, fotografie e modelli di oltre sessanta progetti realizzat
Mario Botta
No full textType d’entité Personne Nom du producteur Mario Botta Dates d’existence 1943-…. Histoire Mario Botta est né en 1943 à Mendrisio dans le Tessin. Etabli à Lugano en 1970, il est actif dans le monde entier. Mario Botta devient célèbre grâce à ses maisons individuelles caractérisées par un gros œuvre en béton armé revêtu de brique ou de terre cuite, et par la disparition de la fenêtre au profit de l'ouverture. En fait, ses maisons possèdent une forte luminosité, une volumétrie unitaire, et ..
- …
