2,516 research outputs found
Comparative assessment of trial-level surrogacy measures for candidate time-to-event surrogate endpoints in clinical trials
No full textVarious meta-analytical approaches have been applied to evaluate putative surrogate endpoints (S) of primary clinical endpoints (T), however a systematic assessment of their performance is lacking. Existing methods in the meta-analytic framework can be grouped into two types conventional and model-based trial-level surrogacy (TLS) measures. Both conventional and model-based TLS measures assess the ability to predict the treatment effect on T based on an observed treatment effect on putative S. Conventional TLS measures include correlation coefficients and R-square measures from weighted linear regression. Model-based TLS includes Copula R(2) proposed by Burzykowski et al. (2001). We examined and compared the estimation performance of these frequently used surrogacy measures in a large-scale simulation study. The impact of several key factors on the estimation performance was assessed, including the strength of the true surrogacy, the amount of effective information provided by available data, and the range of within-trial treatment effect on S and T. The TLS can be estimated accurately and precisely by both types of surrogacy measures when the true surrogacy is strong, number of trials is large, and the range of within-trial treatment effects is wide. When one or more factors deviate from the "best" scenarios, both types of TLS measures tend to underestimate the true surrogacy with increased variability. The estimation performance of conventional measures is similar to model-based measures, but with higher computational efficiency. The findings are applied to a large individual patient data pooled analysis in colon cancer. (C) 2011 Elsevier B.V. All rights reserved
A web-based screening tool for near-port air quality assessments
No full textAuthor(s): Isakov, Vlad; Barzyk, Timothy M; Smith, Elizabeth R; Arunachalam, Saravanan; Naess, Brian; Venkatram, Akul
Status & solidarity through codeswitching: three plays by Dolores Prida
No full textThis analysis employs the sociolinguistic framework of status and solidarity (Holmes, 2001) to examine the use of codeswitching on the relational development between the characters in three plays by Cuban-American playwright Dolores Prida. The three plays discussed are Beautiful Se��oritas (1978), Coser y cantar (1981) and Bot��nica (1991). Linguistic scholars recognize the lack of linguistic analysis of literary texts; specifically, codeswitching at present is not fully explored as a linguistic phenomenon in written contexts. Furthermore, Prida's works have never before been appraised using linguistic methodology. Hence, this work aims to add to scholarly research in the fields of codeswitching, discourse analysis, and literary linguistics, using the status and solidarity framework to examine the codeswitching in Dolores Prida's plays. Dolores Prida is a feminist and Hispanic dramatist whose central theme is the search for identity of Hispanic immigrants, specifically women, in the United States today. Due to her ideological stance, it is expected that a strong emphasis on solidarity rather than status and the use of affective rather than referential speech functions are present in the relationships in her plays. Accordingly, the analysis of Bot��nica reveals that indeed codeswitching between the characters does affect their relational development in maintaining solidarity and intimacy. However, the relationships found in Beautiful Se��oritas and Coser y cantar do not offer such conclusions, due to the variable nature of the relationships identified. Further analysis of these and other literary works will more accurately determine benefits of the status and solidarity framework as applied to the codeswitching research
Catholic Comments Podcast.
No full textFr. Brian McCoy, S.J. discusses his ministry to aboriginal Australians.
McCoy is an anthropologist and a scholar in residence at Creighton University this semester. He is also the author of the book, “Holding Men,” which studies health issues among aboriginal men
Botulinum neurotoxin for head and neck disorders/ [edited by] Andrew Blitzer, Brian E. Benson, Diana N. Kirke
No full textIncludes bibliographical references and index"Senior author Dr. Andrew Blitzer is an internationally renowned pioneer on the use of botulinum neurotoxin for functional disorders, with unparalleled expertise on this topic. Joined by co-editors Brian Benson and Diana Kirke, with multidisciplinary contributors, Botulinum Neurotoxin for Head and Neck Disorders Second Edition fills a gap in the medical literature. The unique textbook focuses on the use of botulinum neurotoxins for functional disorders of the head and neck, though with some aesthetic indications. The second edition reflects the latest advances and understanding of existing and emerging applications for botulinum neurotoxins, including new treatment paradigms, revised pharmacology, and an updated review of the literature in all chapters. Twenty superbly illustrated chapters cover the management of hyperfunctional, pain, and hypersecretory syndromes of the head and neck. Hyperfunctional motor disorders are discussed in chapters focused on blepharospasm, facial dystonia, Meige syndrome, oromandibular dystonia, spasmodic dysphonia (laryngeal dystonia), and cervical dystonia. Specific treatment approaches for pain are addressed in chapters on migraine and chronic daily tension headaches, temporomandibular disorders, and trigeminal neuralgia. The treatment of autonomic nervous system disorders is covered in chapters dedicated to Frey syndrome, facial hyperhydrosis, and sialorrhea"--Pharmacology of Botulinum Neurotoxins / Muna I. Bitar, Nikita Kohli, Maya Samman, and Andrew Blitzer -- Botulinum Neurotoxin for Blepharospasm / Amit Patel, Andrew Blitzer, and Boris L. Bentsianov -- Botulinum Neurotoxin for Facial Dystonia / Scott M. Rickert, Amy P. Wu, and Andrew Blitzer Botulinum -- Neurotoxin for Meige Syndrome / Niv Mor and Andrew Blitzer -- Botulinum Neurotoxin for Oromandibular Dystonia / Daniel Novakovic and Ajay E. Chitkara -- Botulinum Neurotoxin for Spasmodic Dysphonia / Phillip C. Song, Lucian Sulica, and Andrew Blitzer -- Botulinum Neurotoxin for Cervical Dystonia / Tanya K. Meyer, Joel Guss, and Ronda E. Alexander -- Botulinum Neurotoxin for Hemifacial Spasm and Facial Synkinesis / Lesley French Childs, Daniel Novakovic, and Scott R. Gibbs -- Botulinum Neurotoxin for Hyperfunctional Facial Lines / Brian E. Benson, Diana N. Kirke, and Andrew Blitzer -- Botulinum Neurotoxin for Upper and Lower Esophageal Spasm / Nwanmegha Young and Brian E. Benson -- Botulinum Neurotoxin for Palatal Myoclonus / Ajay E. Chitkara, Catherine F. Sinclair, and Daniel Novakovic -- Botulinum Neurotoxin for Temporomandibular Disorders, Masseteric Hypertrophy, and Cosmetic Masseter Reduction / Michael Z. Lerner and Andrew Blitzer -- Botulinum Neurotoxin Therapy in the Laryngopharynx / Craig H. Zalvan, Phillip C. Song, Nwanmegha Young, and Andrew Blitzer -- Botulinum Neurotoxin for Migraine / Rachel Kaye, Jerome Schwartz, Brian E. Benson, and William J. Binder -- Botulinum Neurotoxin for Chronic Tension Headache / Nwanmegha Young and Brian E. Benson -- Botulinum Neurotoxin for Trigeminal Neuralgia / Elizabeth Guardiani, Andrew Blitzer, Lesley French Childs, and Ronda E. Alexander -- Botulinum Neurotoxin for Frey's Syndrome / Rachel Kaye, Andrew Blitzer, and Brian E. Benson -- Botulinum Neurotoxin for Facial Hyperhidrosis / Diana N. Kirke, Daniel Novakovic, and Andrew Blitzer -- Botulinum Neurotoxin for Sialorrhea / Brianna K. Crawley, Scott M. Rickert, Senja Tomovic, and Andrew Blitzer -- Botulinum Neurotoxin for Radiation-Induced Spasm and Pain / Diana N. Kirke, Brian E. Benson, and Tanya K. Meyer1 online resourc
CONSERVA BIO: APLICATIVO INFORMATIVO-DID?TICO SOBRE O JARDIM BOT?NICO DE JO?O PESSOA/PB
No full textO Conserva Bio ? um aplicativo informativo-did?tico desenvolvido para facilitar o acesso ?s
informa??es sobre a biodiversidade, ? fauna, ? flora e ? hist?ria do Jardim Bot?nico
Benjamim Maranh?o (JBBM), localizado em Jo?o Pessoa, Para?ba. Este projeto surgiu em
resposta ?s restri??es impostas pela pandemia de COVID-19, que limitou o acesso a
espa?os de educa??o ambiental e evidenciou a necessidade de recursos digitais que
promovam a educa??o ambiental. A proposta do Conserva Bio ? oferecer uma experi?ncia
de visita??o virtual imersiva, permitindo que usu?rios explorem o Jardim Bot?nico de
maneira aut?noma e interativa. O aplicativo integra conte?dos visuais e funcionais, como
textos, imagens e um game interativo, com o intuito de promover a continuidade da
aprendizagem e o engajamento com a natureza. Essa abordagem visa n?o apenas suprir a
car?ncia de ferramentas digitais, mas tamb?m sensibilizar o p?blico para a import?ncia da
preserva??o ecol?gica. Durante o processo de desenvolvimento, observou-se uma escassez
de aplicativos semelhantes no Brasil, especialmente voltados para jardins bot?nicos e que
integrem tecnologia interativa com a educa??o ambiental. Iniciativas como o Projeto Flora do
Brasil 2020 documentam a flora nacional, mas carecem da interatividade que o Conserva
Bio prop?e. Assim, o aplicativo se destaca ao integrar a hist?ria e a biodiversidade de um
espa?o local espec?fico, proporcionando uma experi?ncia educativa ?nica e contextualizada.
O desenvolvimento do Conserva Bio se baseou em observa??es feitas pelo pesquisador
durante est?gio no JBBM, que revelaram a necessidade de promover a biodiversidade do
local ? sociedade e ao ambiente educacional. Para abordar essa quest?o, uma pesquisa
bibliogr?fica inicial identificou a aus?ncia de aplicativos dedicados ?s Unidades de
Conserva??o no Brasil. Ap?s essa constata??o, o projeto foi submetido ? chamada
Interconecta chamada Interconecta de n?mero 02/2021 do IFPB - Campus Cabedelo e
aprovado com bolsa, al?m de ter recebido a autoriza??o do Conselho de ?tica em Pesquisa.
O procedimento metodol?gico incluiu a coleta de dados por meio de um question?rio com
funcion?rios do JBBM. Apesar de ter uma amostra reduzida, as respostas indicaram uma
significativa car?ncia de recursos digitais. A equipe enfatizou a import?ncia de um aplicativo
que n?o apenas reunisse informa??es, mas que tamb?m engajasse o p?blico por meio de
interatividade. O Conserva Bio tamb?m pode servir como um recurso pedag?gico valioso,
integrando-se a curr?culos escolares e atividades extracurriculares. Por meio de suas
funcionalidades, o aplicativo permite que professores utilizem conte?dos digitais de forma
inovadora, estimulando o aprendizado ativo e o desenvolvimento do pensamento cr?tico em
alunos de diversas idades. Embora a vers?o beta do aplicativo tenha sido um avan?o, o
atraso na implementa??o da vers?o final destacou a necessidade de ajustes que ainda
precisam ser feitos. As contribui??es do Conserva Bio s?o te?ricas, ao enriquecer a
discuss?o sobre o uso de tecnologias digitais na educa??o ambiental, e pr?ticas, ao servir
como uma ferramenta de aprendizado acess?vel a diversos p?blicos. Para estudos futuros,
recomenda-se uma avalia??o cont?nua do aplicativo ap?s sua implementa??o, incluindo
novas funcionalidades, como a finaliza??o do jogo e atualiza??es de conte?do. O Conserva
Bio representa um passo importante na integra??o da tecnologia com a educa??o ambiental,
demonstrando que ? poss?vel avan?ar na divulga??o e valoriza??o da biodiversidade
Supernova shrapnel: nearby supernovae and dust transport in the ISM
No full textThe last 2 decades have seen the proposal, detection, and confirmation of live ^60Fe radioisotopes from an extra-solar source on Earth, showing an event outside the Solar System directly delivered material to the Earth since its formation. This work examines the possible sources for the ^60Fe and models the passage of the material from its source through the Solar System to the ocean floor. We consider the production and deposition on Earth of isotopes with half-lives in the range 10^5 to 10^8 years that might provide signatures of nearby stellar explosions, extending previous analyses of Core-Collapse Supernovae (CCSNe) to include Electron-Capture Supernovae (ECSNe), Super-Asymptotic Giant Branch (SAGBs) stars, Thermonuclear/Type Ia Supernovae (TNSNe), and Kilonovae/Neutron Star Mergers (KNe). We revisit previous estimates of the ^60Fe and ^26Al signatures, and extend these estimates to include ^244Pu and ^53Mn. We show that (i) the ^60Fe yield rules out the TNSN and KN interpretations, (ii) the ^60Fe signals highly constrain a SAGB interpretation but do not completely them rule out, (iii) are consistent with a CCSN origin, and (iv) are highly compatible with an ECSN interpretation.
We also examine various influences on the path of interstellar dust carrying ^60Fe from a SN through the Heliosphere, with the aim of estimating the final global distribution on the ocean floor. We study the influences of magnetic fields, angle of arrival, wind and ocean cycling of SN material on the concentrations at different locations. We find that the passage of SN material through the mesosphere/lower thermosphere (MLT) is the greatest influence on the final global distribution, with ocean cycling causing lesser alteration as the SN material sinks to the ocean floor. SN distance estimates in previous works that assumed a uniform distribution are a good approximation. Including the effects on surface distributions, we estimate a distance of 46^(+10)_(-6) pc for an ECSN progenitor. We note that the SN dust retains directional information to within 1^(circ) through its arrival in the inner Solar System, so that SN debris deposition on inert bodies such as the Moon will be anisotropic, and thus could in principle be used to infer directional information.
Lastly, we examine the various influences on the path of dust within a SN remnant (SNR) to determine when/if the dust decouples from the plasma, how much it is sputtered, and where within the ejecta the dust is located. We find that the inclusion of Rayleigh-Taylor (R-T) instabilities are important in studying dust survival as R-T instabilities influence the location of the SN's reverse shock. We also find the presence of a magnetic field within the shocked ISM material will limit the passage of SN dust grains reflecting them or trapping within the heart of the SNR.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2018-08-01The student, Brian Fry, accepted the attached license on 2016-07-04 at 15:08.The student, Brian Fry, submitted this Dissertation for approval on 2016-07-04 at 15:23.This Dissertation was approved for publication on 2016-07-08 at 16:47.DSpace SAF Submission Ingestion Package generated from Vireo submission #9750 on 2016-11-10 at 12:24:50Made available in DSpace on 2016-11-10T18:39:16Z (GMT). No. of bitstreams: 2
FRY-DISSERTATION-2016.pdf: 10656279 bytes, checksum: 4e1be1f79a71e1417f54d190dc1ba4e3 (MD5)
LICENSE.txt: 4206 bytes, checksum: 2fa157ab76c1e3bf97094664353e401f (MD5)
Previous issue date: 2016-07-08Embargo set by: Seth Robbins for item 95449
Lift date: 2018-11-10T18:39:22Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 95449
Lift date: 2018-11-10T18:43:22Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 95449 on 2018-11-11T10:15:45Z
Give growth and macroeconomic stability in Russia a chance - harden budgets by eliminating nonpayments
No full textThe authors analyze the links between Russia's disappointing growth performance in the second half of the 1990s, its costly and unsuccessful stabilization, the macroeconomic meltdown of 1998, and the spectacular rise of non-payments. Non-payments flourished in an environment of fundamental inconsistency between a macroeconomic policy geared at sharp disinflation, and a microeconomic policy of bailing enterprises out through soft budget constraints. Heavy untargeted implicit subsidies flowing through the non-payments system (amounting to 10 percent of GDP annually) have stifled growth, contributed to the August 1998 meltdown, through their impact on public debt, and have made at best a questionable contribution to equity. Dismantling this system must be a top priority, along with promoting enterprise restructuring and growth (by hardening budget constraints) and medium-term macroeconomic stability (by reducing the size of subsidies). Getting the government out of the non-payments system means settling all appropriately controlled budgetary expenditures on time, and in cash, and eschewing spending arrears, thereby setting an example for enterprises, and laying the groundwork for eliminating tax offsets at all levels of government, and insisting on cash tax payments. To stop energy-related subsidies, would require not only that the government pay its own energy bills on time, and in cash, but also that the energy monopolies be empowered to disconnect non-paying clients. This will enable the government to insist that the energy monopolies in turn pay their own taxes in full, and on time.Banks&Banking Reform,Public Sector Economics&Finance,Economic Theory&Research,Payment Systems&Infrastructure,Environmental Economics&Policies,Banks&Banking Reform,Environmental Economics&Policies,Municipal Financial Management,Public Sector Economics&Finance,Economic Theory&Research
Author Correction: Dental anomaly detection using intraoral photos via deep learning (Scientific Reports, (2022), 12, 1, (11577), 10.1038/s41598-022-15788-1)
No full textIn the original version of this Article Ronilo Ragodos, Tong Wang and Brian J. Howe were omitted as equally contributing authors. Tong Wang was omitted as an additional corresponding author. Correspondence and requests for materials should also be addressed to [email protected]. In addition, the Author Contributions section in this Article was incorrect.Fil: Ragodos, Ronilo. University of Iowa; Estados UnidosFil: Wang, Tong. University of Iowa; Estados UnidosFil: Padilla, Carmencita. University of the Philippines; FilipinasFil: Hecht, Jacqueline T.. University of Texas; Estados UnidosFil: Poletta, Fernando Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; ArgentinaFil: Orioli, Ieda Maria. Universidade Federal do Rio de Janeiro; BrasilFil: Buxó, Carmen J.. Universidad de Puerto Rico; Puerto RicoFil: Butali, Azeez. University of Iowa; Estados UnidosFil: Valencia Ramirez, Consuelo. Clinica Noel; ColombiaFil: Restrepo Muñeton, Claudia. Clinica Noel; ColombiaFil: Wehby, George. University of Iowa; Estados UnidosFil: Weinberg, Seth M.. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados UnidosFil: Marazita, Mary L.. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados UnidosFil: Moreno Uribe, Lina M.. University of Iowa; Estados UnidosFil: Howe, Brian J.. University of Iowa; Estados Unido
The nature of ammonium ion disorder in ammonium tetrafluoroaluminate, NHAlF
No full textPT: J; CR: BERRY LG, 1976, POWDER DIFFRACTION F BRADE RM, 1971, J PHYS C SOLID STATE, V4, P876 BULOU A, 1982, MATER RES BULL, V17, P391 CHIHARA H, 1983, PHYS CHEM, V87, P188 COUZI M, 1983, PHYS CHEM, V87, P232 COUZI M, 1985, J PHYS-PARIS, V46, P435 DAGHORN Y, 1985, J PHYS C SOLID STATE, V18, P383 FOURQUET JL, 1979, REV CHIM MINER, V16, P490 GIRDHAR HL, 1968, J CHEM ENG DATA, V13, P239 KNOP O, 1985, CAN J CHEM, V63, P516 KOBAYASHI K, 1985, SOLID STATE COMMUN, V53, P719 LAUNAY JM, 1984, MATER RES SOC S P, V21, P167 LEBLE A, 1982, PHYS STATUS SOLIDI, V69, P249 MACKOWIAK M, 1984, MAT RES B, V19, P249 NYQUIST RA, 1971, INFRARED SPECTRA INO PARSONAGE NG, 1978, DISORDER CRYSTALS SHINN DB, 1966, INORG CHEM, V5, P1927 SIMON F, 1922, ANN PHYS-BERLIN, V68, P241 VANOORT MJM, J CHEM SOC F1 WAGNER EL, 1950, J CHEM PHYS, V18, P296 WEIR RD, 1980, J CHEM PHYS, V73, P1386 WESTRUM EF, 1969, J CHEM PHYS, V50, P5083 WHITE MA, UNPUB WHITE MA, 1981, J CHEM THERMODYN, V13, P283 WHITE MA, 1984, THERMOCHIM ACTA, V74, P55; NR: 25; TC: 9; J9: J CHEM PHYS; PG: 5; GA: AUR04Source type: Electronic(1
- …
