2,820 research outputs found
Observation of hc radiative decay hc › ??' and evidence for hc › ??
No full textKolcu, Onur Buğra (Arel Author) --- Makale 69 yazarlıdır.A search for radiative decays of the P-wave spin singlet charmonium resonance hc is performed based on 4.48 × 108 ? events collected with the BESIII detector operating at the BEPCII storage ring. Events of the reaction channels hc › ??' and ?? are observed with a statistical significance of 8.4? and 4.0?, respectively, for the first time. The branching fractions of hc › ??' and hc › ?? are measured to be B(hc › ??' ) = (1.52±0.27±0.29)×10-3 and B(hc › ??) = (4.7±1.5±1.4)×10-4 , respectively, where the first errors are statistical and the second are systematic uncertainties
Cognition in Parkinson's Disease: an examination of clinically meaningful subgroups
No full textThesis (Ph.D.)--Boston University
PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at [email protected]. Thank you.The nature and progression of cognitive change in Parkinson's disease (PD) are not well understood and may depend on subgroup membership. Though investigators have examined subgroups with respect to cognition, most use limited neuropsychological assessments and do not account for important disease and participant characteristics. The present series of studies was designed to systematically examine potentially informative subgroups.
Cognition, mood and quality of life were evaluated in 65 nondemented PD patients and 54 age- and education-matched healthy control participants (HC). Neuropsychological measures of executive, visuospatial, memory and psychomotor function, as well as questionnaires of mood, anxiety, daily functioning and quality of life were administered to all participants.
The first study compared motor subtype measurement methodologies and examined the differential value of tremor vs. non-tremor motor subtypes in understanding PD-related cognition. The patients with non-tremor but not tremor motor subtype performed significantly worse than HC on tests of executive, visuospatial, and psychomotor function, and endorsed more anxiety.
The second study compared men and women with PD to HC men and women on cognition and mood, and compared men and women with PD on quality of life and motor, vision and activities of daily living. Gender was unrelated to any clinical or mood variable or to performance on most cognitive tests.
The third study compared PD and HC on cognitive abilities known to be supported by frontal- vs. posterior-cortical lobes in order to determine the usefulness of considering type of neuropsychological deficit as an indicator of disease status. Half the PD participants were categorized in a deficit group based on performance of the frontaland posterior-type tests, and several more exhibited deficits at a sub-threshold level. Examination of individual test performance highlighted executive-function and psychomotor tests that were particularly sensitive to cognition in PD.
Taken together, these studies suggest that motor subtype and frontal-posterior cortical subtype but not gender may be important to understanding cognition in highfunctioning, non-demented PD patients. This information may be applicable to investigations of the nature and progression of cognitive change in this disorder
Routine use of a standardised assessment instrument for measuring the outcome of social care
No full textThis study had as its primary aim determining the extent to which standardised assessment can contribute to monitoring the outcomes of social care. It also addressed the comparison of resource use between individual clients, groups of clients with similar characteristics and between Social Service Departments (SSD's). An important part of the study was exploring the views of Social Workers and Care Managers on assessment in general and standardised assessment and the MDS-HC in particular. It has succeeded in achieving the majority of its goals and its findings have been incorporated into a revised MDS-HC assessment system including the development of a simplified screening assessment. It has also identified how attitudes to assessment, the manner in which assessment is done, and the organisation of assessment and on going management of services provided was significantly different between the two social service departments that took part in the study. Some of the issues identified are important for the development of policy on assessment in community care. It is likely that the findings are widely generalisable
Salivary diagnosis for celiac disease
No full textPLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please log in with a valid BU account to access and click Download. If you are the author of this work and would like to make it publicly available, please contact [email protected] (MSD) --Boston University, Henry M. Goldman School of Dental Medicine, 2014 (Department of Periodontology and Oral Biology)xi, 66 leavesIncludes bibliography: leaves 56-64.Celiac disease is a gluten-sensitive enteropathy, characterized by an inflammatory reaction in the small intestine triggered by gluten proteins. Clinical consequences include malabsorption of nutrients due to the loss of absorptive villi and crypt hyperplasia. Certain similarities are found between the primary structures of gluten and salivary proline-rich proteins. These structural similarities can give an interesting perspective to the manner salivary proteins can be regarded in the celiac disease mechanism.
Salivary proteome analyses have revealed a great potential for the diagnosis of systemic diseases. The concept of saliva as a diagnostic fluid is alluring because it is easily collected in a non-invasive manner, and the number of potential applications is rapidly increasing. The main focus of our study is to compare saliva composition, with emphasis on proline-rich proteins, in samples collected from healthy and celiac patients.
A multisite clinical study was initiated, in collaboration with the Department of Medicine and Division of Gastroenterology at Beth Israel Deaconess Medical Center Boston, MA. Healthy and celiac patients are being recruited, consented, and asked to fill out three questionnaires probing oral health, overall gastrointestinal health and symptoms characteristic of celiac disease. From all participating subjects 10 ml of stimulated whole saliva and parotid saliva were being collected as well as two buccal epithelial swab samples. Salivary flow rate was monitored throughout the collection. Collected whole saliva samples were aliquoted, centrifuged and separated into supernatant and pellet fractions.
So far samples from 42 subjects have been collected and processed: 19 from celiac disease patients (CD), 6 from refractory celiac disease patients (RCD), 6 from gastrointestinally symptomatic patients (GI), and and 11 from healthy control subjects (HC). Subjects also completed a series of gastrointestinal and oral health questionnaires, that revealed certain trends indicating that RCD patients tend to have significantly stronger symptomatic manifestations than subjects from the other groups, followed by CD and GI. Oral health questionnaires showed that subjects from all groups maintained, on average, good oral hygiene habits. Statistical analysis of flow rate distribution data showed no significant difference in saliva flow between sample groups. Future biological analysis will include proteome composition determination by SDS-PAGE and RP-HPLC, enzyme activity analysis, salivary microbiome analysis, and exon sequencing of mammalian genes of interest
Financial analysis and evaluation of company HC Betons Ltd
No full textDiplomdarba nosaukums: Uzņēmuma SIA HC Betons finanšu analīze un novērtējums
Diplomdarba mērķis ir uz finanšu analīzes pamata izvērtēt uzņēmuma SIA HC Betons esošo finansiālo situāciju un izstrādāt priekšlikumus finansiālā stāvokļa uzlabošanai.
Teorētiskajā daļā apskatīti finanšu analīzes teorētiskie aspekti. Praktiskajā daļā autore veica uzņēmuma SIA HC Betons finanšu analīzi par 2009., 2010., un 2011.gadu. Analītiskajā daļā autore salīdzina rādītājus ar konkurējošo uzņēmumu SIA Cemex.
Autore secinājusi, ka uzņēmumam ir finansiālas grūtības, bet pēc autores domām, uzņēmums tuvāko gadu laikā nebankrotēs.
Diplomdarba apjoms ir 78 lapaspuses, tas sastāv no 3 daļām, 12 tabulām, 5 attēliem un 12 pielikumiem.
Atslēgvārdi: analīze, likviditāte, bankrots, koeficienti.Diploma thesis: Financial Analysis and Evaluation of Company HC Betons Ltd.
The aim of the diploma paper is to evaluate company’s HC Betons Ltd current financial situation based on financial analysis and make suggestions for improvement of the financial position.
Theoretical aspects of financial analysis are discussed in the theoretical part of the paper. In the practical part author has performed company’s HC Betons Ltd financial analysis of the years 2009, 2010 and 2011. In the analytical part author compares ratios of a competing company Cemex Ltd.
The author concludes that the company is in financial difficulties, but according to the author’s thoughts, the company will not bankrupt in the coming years.
The volume of the diploma paper is 78 pages; it consists of 3 parts, 12 tables, 5 images and 12 appendices.
Keywords: analysis, liquidity, bankruptcy, ratios
Metabolic profiling and population screening of analgesic usage in nuclear magnetic resonance spectroscopy-based large-scale epidemiologic studies
No full textThe application of a 1H nuclear magnetic resonance (NMR) spectroscopy-based screening method for determining the use of two widely available analgesics (acetaminophen and ibuprofen) in epidemiologic studies has been investigated. We used samples and data from the cross-sectional INTERMAP Study involving participants from Japan (n = 1145), China (n = 839), U.K. (n = 501), and the U.S. (n = 2195). An orthogonal projection to latent structures discriminant analysis (OPLS-DA) algorithm with an incorporated Monte Carlo resampling function was applied to the NMR data set to determine which spectra contained analgesic metabolites. OPLS-DA preprocessing parameters (normalization, bin width, scaling, and input parameters) were assessed systematically to identify an optimal acetaminophen prediction model. Subsets of INTERMAP spectra were examined to verify and validate the presence/absence of acetaminophen/ibuprofen based on known chemical shift and coupling patterns. The optimized and validated acetaminophen model correctly predicted 98.2%, and the ibuprofen model correctly predicted 99.0% of the urine specimens containing these drug metabolites. The acetaminophen and ibuprofen models were subsequently used to predict the presence/absence of these drug metabolites for the remaining INTERMAP specimens. The acetaminophen model identified 415 out of 8436 spectra as containing acetaminophen metabolite signals while the ibuprofen model identified 245 out of 8604 spectra as containing ibuprofen metabolite signals from the global data set after excluding samples used to construct the prediction models. The NMR-based metabolic screening strategy provides a new objective approach for evaluation of self-reported medication data and is extendable to other aspects of population xenometabolome profiling
Specific and fitness testing of goalies HC Motor Czech Budejovice\\
No full textThe aim of this bachelor thesis is to test specific and fitness abilities of goalkeepers of HC Motor Czech Budejovice. In the theoretical part of this thesis, based on content analysis of literature research, the author presents motoric abilities, development patterns and overview of most frequently used tests. In the practical part of thesis, the author deals with creating and verifying tested battery. It was designed using the knowledge gained from books reference and self- experience of a player and a coach as well. To obtain the results of performance of particular motoric abilities the author used testing method. The outcomes were subsequently compared with the evaluation of given motoric abilities on ice. The author acquired the evaluation from goalkeeper's coaches of HC Motor Czech Budejovice. Final results are described and thereafter tabularly presented
VIBRATIONAL RELAXATION IN THE BINARY GASEOUS MIXTURES AND
No full textAuthor Institution: Laboratoire de Spectronomie Moleculaire, Universit\'e de Paris VI, 4, Place Jussieu - Tour 13Vibrational relaxation rates for gaseous mixtures , with or , in which vibrational energy transfer can occur from the level of M to the v = 1 level of , has been measured as a function of the temperature using the laser-induced vibrational fluorescence technique. The relaxation processes which must be considered are: - the V-V transfer process: \begin{eqnarray*} &&M(00^{\circ }1)+ HC (v=0)\begin{array}{c}^{k}M-HC\ell\\ \rightleftharpoons\\ ^{k}HC\ell-M\end{array}M(00^{\circ}0)+ HC\ell(v=1)+ \Delta E=he\Delta\nu\\ &&with\ \Delta\nu=-537\, cm^{-1} for\ CO_{2}, -663\, cm ^{-1}\ for\ N_{2}O \end{eqnarray*} - the V-TR de-excitation processes: \begin{eqnarray*} M(00^{\circ}1)+ HC\ell(or M)\stackrel{k^{HC\ell}_{M}}{(o\vec{r}\; k_{M})}M(mn^{\ell}0)+HC\ell (or \; M)\\ HC\ell(v=1)+ M(or\; HC\ell)\stackrel{k^{M}_{HC\ell}}{(o\vec{r}\; k_{HC\ell})}HC\ell(v=0)+M(or \; HC\ell) \end{eqnarray*} For most of the systems in which near-resonant V-V transfers occur, the V-TR de-excitation rates are negligible compared to the V-V transfer rates. But this is not the case for the M-HC systems considered in this work. The de-excitation rates and are of the same order of magnitude as the V-V transfer rates and respectively. In order to determine separately all these rates, relaxation measurements have been performed by exciting either H to the level or to the v = 1 level, and measuring the relaxation rates versus the molar fraction of the gas excited by laser. The results are discussed and compared with the values of the rates calculated by using a Morse potential as the intermolecular potential, and according to a semi-classical method in which a vibration-rotation exchange is assumed
VIBRATIONAL COUPLINGS AND ENERGY FLOW IN COMPLEXES OF HC=CH, HC=CD, HC=CC=C, AND N=CH WITH
No full textAuthor Institution: Molecular Physics Division, National Institute of Standards and Technology; Molecular Physics Divisoin, National Institute of Standards and TechnologyInfrared spectra of the C-H stretching vibrations of the symmetric-top complexes, , have been recorded using a color-center-laser electric-resonance optothermal spectrometer. Efforts to observe the N-H stretches were unsuccessful. The hydrogen-bonded C-H stretching modes of HC=CH--NH3 are strongly coupled to the hydrogen bond as evidenced by their large monomer red-shifts of 75 and and broad predissociation linewidths of 2000 ad 650-800 MHz, respectively. The complexation-induced asymmetry in is not sufficient to allow us to observe the local mode associated with the outer C-H stretch. However, isotopic substitution in shows that this mode is red shifted by less than from the monomer vibration. The narrow predissociation linewidths of this mode (7-12 MHz) are consistent with this small red shift. The weaker coupling of the C-H stretches in HC=CC=CH is completely quenched upon complexation with . The outer C-H stretch is observed in the diacetylene (HC=CC=CH) complex, blue shifted by approximately from the infrared-active monomer C-H stretch at ; the bound CH stretch is red shifted about the same amount as in . These observations imply that the weak coupling of the local modes in diacetylene is significantly quenched upon complexation with . The predissociation linewidths are similar to those in , even though the outer C-H stretch is now five bonds away from the hydrogen bond. Surprisingly, these results suggest that the length of the triple-bond backbone in acetylene chains does not significantly impede the rate of vibrational energy flow. Future efforts will be made to extend these studies to the triacelyne complex,
Measurements of hc(P11) in ψ ′ Decays
No full textWe present measurements of the charmonium state hc(P11) made with 106×106 ψ ′ events collected by BESIII at BEPCII. Clear signals are observed for ψ ′→π0hc with and without the subsequent radiative decay hc→γηc. First measurements of the absolute branching ratios B(ψ ′→π0hc)=(8. 4±1.3±1.0)×10 -4 and B(hc→γηc)=(54. 3±6.7±5.2)% are presented. A statistics-limited determination of the previously unmeasured hc width leads to an upper limit Γ(hc)<1. 44MeV (90% confidence). Measurements of M(hc)=3525.40±0.13±0. 18MeV/c2 and B(ψ ′→π0hc) ×B(hc→γηc)=(4.58±0.40±0.50)×10 -4 are consistent with previous results. © 2010 The American Physical Society.published_or_final_versio
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