250,776 research outputs found
Incorporating I-131 into a PAMAM (G5.0) dendrimerconjugate: design of a theranostic nanosensor for medullary thyroid carcinoma
No full textCitation: He, R., Wang, H., Su, Y., Chen, C., Xie, L., Chen, L., . . . Bossmann, S. H. (2017). Incorporating I-131 into a PAMAM (G5.0) dendrimerconjugate: design of a theranostic nanosensor for medullary thyroid carcinoma. Rsc Advances, 7(26), 16181-16188. doi:10.1039/c7ra00604gWe report the synthesis and purification of a targeting probe for Medullary Thyroid Carcinoma (MTC) by incorporating I-131 into PAMAM (G5.0) dendrimers. Both the I-131 labeled control dendrimer (I-131-PAMAM (G5.0) without attached targeting peptide) and the MTC-targeting dendrimer (I-131-PAMAM (G5.0) attached to VTP (vascular targeting peptide)) were labeled with the radioisotope I-131 by applying the iodogen method. The resulting G5.0 dendrimers were purified by means of ultracentrifugation. The labelling efficiencies and radiochemical purities vs. time were determined by paper chromatography. The radiolabeling efficiencies of I-131-PAMAM (G5.0) and I-131-PAMAM (G5.0) were 93 +/- 1% and 85 +/- 2%, respectively. I-131-PAMAM (G5.0) did exhibit small, but significant changes in radiochemical purity as a function of time after labelling. The highest observed highest purity was 82 +/- 2%. I-131-PAMAM (G5.0)VTP did display larger changes in radiochemical purity as a function of time after labelling, maximally 80 +/- 2%. The stability of the two probes and their binding behavior to the human medullary thyroid cancer cell line (TT) were observed in vitro. Compared to the negative control group (consisting of (NaI)-I-131), the TT cell binding rate of 131I-PAMAM (G5.0)-VTP was significantly increased at 48 h and 72 h (P 0.05). These findings have been confirmed by performing MTT assays. These results confirm earlier findings, which demonstrated fast uptake of PAMAM (G5.0) by various cell types
A 2 h periodic variation in the low-mass X-ray binary Ser X-1
No full textSpectroscopy of the low-mass X-ray binary Ser X-1 using the Gran Telescopio Canarias have revealed a ?2 h periodic variability that is present in the three strongest emission lines. We tentatively interpret this variability as due to orbital motion, making it the first indication of the orbital period of Ser X-1. Together with the fact that the emission lines are remarkably narrow, but still resolved, we show that a main-sequence K dwarf together with a canonical 1.4 M? neutron star gives a good description of the system. In this scenario, the most likely place for the emission lines to arise is the accretion disc, instead of a localized region in the binary (such as the irradiated surface or the stream-impact point), and their narrowness is due instead to the low inclination (?10°) of Ser X-1
Microstructural characterization of porous thermal barrier coatings by IR gas porosimetry and sintering forecasts
No full textIt is known that the thermal diffusivity of plasma sprayed coatings is quite sensitive to the operating conditions, namely the composition and pressure of the operating atmosphere. This makes it possible, in principle, to obtain information, in a non-destructive way, on the microstructure of thermal barrier coatings (TBCs) from thermal diffusivity measurements. An experimental assessment of this idea is presented in this paper. The microstructure of as-sprayed and sintered free-standing atmospheric plasma sprayed YPSZ TBC samples have been characterized by a new technique, named infrared (IR) gas porosimetry, as well as by mercury intrusion porosimetry and image analysis. The results from these different techniques have been compared. Furthermore, the microstructure and thermal diffusivity of sintered samples have been compared with the sintering forecasts produced by Cipitria’s sintering code coupled with the Bruggeman model for thermal diffusivity estimation. Sample-to-sample variations have been discussed and uncertainties in experimental techniques have been analysed. Conditions for accurate microstructural estimations have been obtained and suggestions on the reliability of the statistical evaluation are provide
Elucidation of Acceptor-Acceptor Interactions in a Ru(II) Supramolecular Photosynthetic Model Complex
No full textSynthesis and Characterization of Nitroxide-Linked Ruthenium Complexes as Molecular Probes for Microheterogeneous Environments
No full textEfficient p-Multigrid Based Solvers for Isogeometric Analysis on Multipatch Geometries
No full textIsogeometric Analysis can be considered as the natural extension of the Finite Element Method (FEM) to higher-order spline based discretizations simplifying the treatment of complex geometries with curved boundaries. Finding a solution of the resulting linear systems of equations efficiently remains, however, a challenging task. Recently, p-multigrid methods have been considered [18], in which a multigrid hierarchy is constructed based on different approximation orders p instead of mesh widths h as it would be the case in classical h-multigrid schemes [8]. The use of an Incomplete LU-factorization as a smoother within the p-multigrid method has shown to lead to convergence rates independent of both h and p for single patch geometries [19]. In this paper, the focus lies on the application of the aforementioned p-multigrid method on multipatch geometries having a C0-continuous coupling between the patches. The use of ILUT as a smoother within p-multigrid methods leads to convergence rates that are essentially independent of h and p, but depend mildly on the number of patches.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Numerical Analysi
Physico-Chemical Studies on the Adsorption Properties of Asbestos.2. an EPR and Fluorescence Study on the Adsorption of Pyrene
No full textGoing Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Novel high performance poly(p-phenylene benzobisimidazole) (PBDI) membranes fabricated by interfacial polymerization for H 2 separation
No full text Membranes with high selectivity and permeance are needed to reduce energy consumption in hydrogen purification and pre-combustion CO 2 capture. Polybenzimidazole (PBI) is one of the leading membrane materials for this separation. In this study, we present superior novel supported PBI (poly(p-phenylene benzobisimidazole), PBDI) membranes prepared by a facile interfacial polymerization (IP) method. The effect of IP reaction duration, operating temperature and pressure on membrane separation performance was systematically investigated. The best performance was achieved for membranes prepared in a 2 h reaction time. The resulting membranes display an ultrahigh mixed-gas H 2 /CO 2 selectivity of 23 at 423 K together with an excellent H 2 permeance of 241 GPU, surpassing the membrane performance of conventional polymers (the 2008 Robeson upper bound). These separation results, together with the facile manufacture, pressure resistance, long-term thermostability (>200 h) and economic analysis, recommend the PBDI membranes for industrial use in H 2 purification and pre-combustion CO 2 capture. Besides, PBDI membranes possess high selectivities towards H 2 /N 2 (up to 60) and H 2 /CH 4 (up to 48) mixtures, indicating their potential applications in ammonia synthesis and syngas production. Accepted Author ManuscriptChemE/Catalysis EngineeringOLD ChemE/Organic Materials and InterfacesRST/Storage of Electrochemical Energ
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