203 research outputs found
Phylogenetic tree pigs
No full textNeighbor-joining phylogenetic tree based a PLINK distance matrix for 2288220 markers in 40 pigs and wild boar from Europe and Asia
Genetic load: Genomic estimates and applications in non-model animals
No full textGenetic variation, which is generated by mutation, recombination and gene flow, can reduce the mean fitness of a population, both now and in the future. This ‘genetic load’ has been estimated in a wide range of animal taxa using various approaches. Advances in genome sequencing and computational techniques now enable us to estimate the genetic load in populations and individuals without direct fitness estimates. Here, we review the classic and contemporary literature of genetic load. We describe approaches to quantify the genetic load in whole-genome sequence data based on evolutionary conservation and annotations. We show that splitting the load into its two components — the realized load (or expressed load) and the masked load (or inbreeding load) — can improve our understanding of the population genetics of deleterious mutations
Loss of function mutations in essential genes cause embryonic lethality in pigs.
No full textSupplementary data for publication: Martijn F.L. Derks, Arne B. Gjuvsland, Mirte Bosse, Marcos S. Lopes, Maren van Son, Barbara Harlizius, Beatrice F. Tan, Eli Grindflek, Martien A.M. Groenen, Hendrik-Jan Megens. (2019). Loss of function mutations in essential genes cause embryonic lethality in pigs. PLoS genetics 15(3)
Accelerated discovery of functional genomic variation in pigs
No full textRepository for the study:
Accelerated discovery of functional genomic variation in pigs
Martijn F.L. Derks, Christian Gross, Marcos S. Lopes, Marcel J.T. Reinders, Mirte Bosse, Arne B. Gjuvsland, Dick de Ridder, Hendrik-Jan Megens, Martien A.M. Groenen
Published in the thesis of Martijn Derks (chapter 8).
Repository contains the supplementary material of this study
Loss of function mutations in essential genes cause embryonic lethality in pigs.
No full textSupplementary data for publication: Martijn F.L. Derks, Arne B. Gjuvsland, Mirte Bosse, Marcos S. Lopes, Maren van Son, Barbara Harlizius, Beatrice F. Tan, Eli Grindflek, Martien A.M. Groenen, Hendrik-Jan Megens. (2019). Loss of function mutations in essential genes cause embryonic lethality in pigs. PLoS genetics 15(3)
Loss of function mutations in essential genes cause embryonic lethality in pigs.
No full textSupplementary data for publication: Martijn F.L. Derks, Arne B. Gjuvsland, Mirte Bosse, Marcos S. Lopes, Maren van Son, Barbara Harlizius, Beatrice F. Tan, Eli Grindflek, Martien A.M. Groenen, Hendrik-Jan Megens. (2019). Loss of function mutations in essential genes cause embryonic lethality in pigs. PLoS genetics 15(3)
Accelerated discovery of functional genomic variation in pigs
No full textRepository for the study:
Accelerated discovery of functional genomic variation in pigs
Martijn F.L. Derks, Christian Gross, Marcos S. Lopes, Marcel J.T. Reinders, Mirte Bosse, Arne B. Gjuvsland, Dick de Ridder, Hendrik-Jan Megens, Martien A.M. Groenen
Published in the thesis of Martijn Derks (chapter 8).
Repository contains the supplementary material of this study
Accelerated discovery of functional genomic variation in pigs
No full textRepository for the study:
Accelerated discovery of functional genomic variation in pigs
Martijn F.L. Derks, Christian Gross, Marcos S. Lopes, Marcel J.T. Reinders, Mirte Bosse, Arne B. Gjuvsland, Dick de Ridder, Hendrik-Jan Megens, Martien A.M. Groenen
Published in the thesis of Martijn Derks (chapter 8).
Repository contains the supplementary material of this study
A genomics perspective on pig domestication
No full textLand animal domestication has typically led to remarkable phenotypic diversity, stemming from a broad genetic background. The process of land animal domestication turns out to be a complex, long-term event with extensive gene-flow between wild and captive populations. Using pig as model, this chapter provides an in-depth overview of domestication-related events leading towards the genetic diversity in extant pig breeds. Five events in the evolutionary history and domestication of pigs can be recognized that are important for the genetic variation in modern pig genomes: (1) Speciation of Sus species in Island South-East Asia (ISEA); (2) Divergence between European and Asian lineages; (3) Independent domestication leading to separate domesticated clades in Europe and Asia; (4) Hybridization between domesticated pigs from Asia and Europe; and (5) Breed formation. Remarkably, the extensive mixture of genetic material leading towards the current European commercial pigs has resulted in domestic breeds that are genetically more diverse than their wild ancestors. Nowadays, commercial breeding and genomics go hand in hand. Genomics has not only proven useful to provide understanding about the domestication history of pigs but also about the molecular mechanisms underlying traits of interest. Moreover, genomic selection is an important tool integral to modern commercial breeding
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