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Editorial: Ozone in medicine: Biochemical background, physiological modulation and clinical applications
Get PDFCitotossicità indotta dall'infuso delle foglie di Annona muricata L. in linee tumorali umane del colon
No full textThe reliable and effective oxygen-ozone therapy at a cross-roads with ozonated saline infusion and ozone rectal insufflation
Get PDFObjectives This review aims to highlight the advantages and safety of oxygen-ozone
therapy (OOT) and to suggest ways to enhance its acceptance.
Key findings The treatment of a herniated disk by injecting a gaseous oxygen-ozone
mixture inside the nucleus pulposus is a great clinical success. However, the use of
OOT lags for a number of reasons, including lack of standardization, the need for
numerous treatments, lack of knowledge and even denial. Anecdotally, several
million treatments by OOT have been performed worldwide indicating its usefulness,
mainly in peripheral arterial diseases and age-related macular degeneration.
The scepticism that accompanies the systemic use of ozone can only be overcome by
demonstrating the validity of OOT in controlled and randomized clinical trials.
Cheaper and quicker methods, such as ozonating physiological saline with successive
infusion as well as ozone rectal insufflations, are becoming popular, however,
such alternative procedures are erratic, unstable and liable to be toxic, with deleterious
consequences, and are likely to discredit the beneficial use of ozone.
Summary The approval of ozone in terms of both therapeutic efficacy and safety
will depend on the results achieved by authoritative clinical trials
The ozone paradox: Ozone is a strong oxidant as well as a medical drug
Get PDFAfter five decades characterized by empiricism and several pitfalls, some of the basic mechanisms
of action of ozone in pulmonary toxicology and in medicine have been clarified. The present
knowledge allows to understand the prolonged inhalation of ozone can be very deleterious first for the
lungs and successively for the whole organism. On the other hand, a small ozone dose well calibrated
against the potent antioxidant capacity of blood can trigger several useful biochemical mechanisms and
reactivate the antioxidant system. In detail, firstly ex vivo and second during the infusion of ozonated
blood into the donor, the ozone therapy approach involves blood cells and the endothelium, which by
transferring the ozone messengers to billions of cells will generate a therapeutic effect. Thus, in spite of a
common prejudice, single ozone doses can be therapeutically used in selected human diseases without
any toxicity or side effects. Moreover, the versatility and amplitude of beneficial effect of ozone applications
have become evident in orthopedics, cutaneous, and mucosal infections as well as in dentistry
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
The usefulness of ozone treatment in spinal pain
Get PDFObjective: The aim of this review is to elucidate the biochemical, molecular, immunological, and pharmaceutical mechanisms of action of ozone dissolved in biological fluids. Studies performed during the last two decades allow the drawing of a comprehensive framework for understanding and recommending the integration of ozone therapy for spinal pain. Methods: An in-depth screening of primary sources of information online – via SciFinder Scholar, Google Scholar, and Scopus databases as well as Embase, PubMed, and the Cochrane Database of Systemic Reviews – was performed. In this review, the most significant papers of the last 25 years are presented and their proposals critically evaluated, regardless of the bibliometric impact of the journals. Results: The efficacy of standard treatments combined with the unique capacity of ozone therapy to reactivate the innate antioxidant system is the key to correcting the oxidative stress typical of chronic inflammatory diseases. Pain pathways and control systems of algesic signals after ozone administration are described. Conclusion: This paper finds favors the full insertion of ozone therapy into pharmaceutical sciences, rather than as either an alternative or an esoteric approach
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