56 research outputs found
Supplemental Material, sj-tif-2-ptd-10.1177_08968608231165865 - Blockade of sodium–glucose co-transporters improves peritoneal ultrafiltration in uraemic rodent models
No full textSupplemental Material, sj-tif-2-ptd-10.1177_08968608231165865 for Blockade of sodium–glucose co-transporters improves peritoneal ultrafiltration in uraemic rodent models by Marina Vorobiov, Boris Rogachev, Reut Riff, Cidio Chaimowitz, Endre Z Neulander, Anna Basok, Alla Shnaider, Amos Douvdevani and Yosef-Shmuel Haviv in Peritoneal Dialysis International</p
Supplemental Material, sj-tif-1-ptd-10.1177_08968608231165865 - Blockade of sodium–glucose co-transporters improves peritoneal ultrafiltration in uraemic rodent models
No full textSupplemental Material, sj-tif-1-ptd-10.1177_08968608231165865 for Blockade of sodium–glucose co-transporters improves peritoneal ultrafiltration in uraemic rodent models by Marina Vorobiov, Boris Rogachev, Reut Riff, Cidio Chaimowitz, Endre Z Neulander, Anna Basok, Alla Shnaider, Amos Douvdevani and Yosef-Shmuel Haviv in Peritoneal Dialysis International</p
Institute of Socio-Political Research of the Russian Academy of Sciences
No full textAbstract: Review of the book by Milovidov V. D. Simmetry of delusions. Uncertainty factors of the global financial market under the technological revolution. Moscow, Magistr, 2019. 336 p. (In Russian).Author declares the absence of conflict of interests
Utrasonographic monitoring of uterine motility in infertile women with adenomyosis = Ультрасонографический мониторинг маточной перистальтики у бесплодных женщин с аденомиозом
No full textGladchuk I. Z., Rogachev A. P., Garbuzenko N. D., Stamova N. A. Utrasonographic monitoring of uterine motility in infertile women with adenomyosis = Ультрасонографический мониторинг маточной перистальтики у бесплодных женщин с аденомиозом. Journal of Education, Health and Sport. 2015;5(12):691-700. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.44823
http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%2812%29%3A691-700
https://pbn.nauka.gov.pl/works/695960
Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).
755 Journal of Education, Health and Sport (null) 2391-8306 7
© The Author (s) 2015;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 20.12.2015. Revised 25.12.2015. Accepted: 29.12.2015.
UTRASONOGRAPHIC MONITORING OF UTERINE MOTILITY IN INFERTILE WOMEN WITH ADENOMYOSIS
Ультрасонографический мониторинг маточной перистальтики у бесплодных женщин с аденомиозом
I. Z. Gladchuk, A. P. Rogachev, N. D. Garbuzenko, N. A. Stamova
И. З. Гладчук, А. П. Рогачевский, Н. Д. Гарбузенко, Н. А. Стамова
Odessa National Medical University, Ukraine
Одесский национальный медицинский университет, Одесса, Украина
Abstract
Taking into account that the uterine pump disruption is one of the leading pathogenic links of infertility in external endometriosis, a significant role of this factor can be detected and in adenomyosis. Diagnosis of uterine peristalsis held with ultrasonography (US), and the study of intrauterine transport was made by hysterosalpingoscintigraphy. Disperistaltic waves at were revealed predominantly in periovulatory phase with the average rate of 4.8 ± 0.23 waves / min. In the control group only single disperistaltic waves throughout the cycle, and their frequency did not exceed 0.4 ± 0.11 waves / min. In all the women with the lack of intrauterine transport either disperistaltic or complete absence of subendometrial layers of myometrium contractions wave were found. The significant increase of hysterosalpingoscintigraphy negative results and contralateral transport depending on the patients’ age was revealed (p <0.01 and p <0.05, respectively). Therefore, patients with adenomyosis and impaired uterine peristaltic older than 30 years old should be recommended one of the techniques of extracorporal fertilization with embryo transfer technology, except for intrauterine insemination.
Key words: adenomyosis, infertility, uterine pump, uterine peristalsis.
Реферат
Учитывая, что нарушение работы маточной помпы - одно из ведущих звеньев патогенеза бесплодия при наружном эндометриозе, может быть обнаружена значимая роль этого фактора и при аденомиозе. Диагностика маточной перистальтики проводится при ультрасонографии (УЗИ), а исследование внутриматочного транспорта – методом гистеросальпингосцинтиграфии (ГССГ). Дисперистальтические волны при аденомиозе обнаружены преимущественно в периовуляторной фазе со средней частотой 4,8±0,23 волн/мин. В контрольной группе наблюдались только единичные дисперистальтические волны на протяжении всего цикла и их частота не превышала 0,4±0,11 волн/мин. У всех женщин с отсутствием внутриматочного транспорта обнаружены дисперистальтика или полное отсутствие волн сокращения субэндометриальных слоев миометрия. В ходе исследований обнаружено, достоверное увеличение числа случаев отрицательных результатов ГССГ и контралатерального транспорта с возрастом пациенток (р<0,01 и p<0,05, соответственно). Поэтому пациенткам с аденомиозом и нарушением маточной перистальтики старше 30 лет следует рекомендовать одну из методик экстракорпорального оплодотворения с технологией переноса эмбриона, исключая внутриматочную инсеминацию.
Ключевые слова: аденомиоз, бесплодие, маточная помпа, маточная перистальтика
CD40 Ligand Expression Correlates with Resolution of Peritonitis and Mononuclear Cell Recruitment
No full text
Update on Peripheral Arterial Vasodilation, Ascites and Hepatorenal Syndrome in Cirrhosis
No full textIn
cirrhosis of the liver, according to the peripheral arterial vasodilation
hypothesis, relative underfilling of the arterial tree triggers a
neurohumoral response (activation of renin-angiotensinaldosterone
system, sympathetic nervous system, nonosmotic release
of vasopressin) aimed at restoring circulatory integrity by
promoting renal sodium and water retention. Evidence has accumulated
for a major role of increased vascular production of nitric
oxide as the primary cause of arterial vasodilation in cirrhosis. Ascites
is a common complication in cirrhosis. Treatment of ascites
consists of a low salt diet with diuretics, and paracentesis together
with plasma volume expanders in diuretic-resistant patients. Progression
of cirrhosis may result in hepatorenal syndrome, a state of
functional renal failure that carries an ominous prognosis. Orthotopic
liver transplantation has remained the only curative treatment
for patients with advanced liver disease; other modalities
such as transjugular intrahepatic portosystemic shunt or vasopressin
analogues may serve as a bridge to transplantation. Another
complication of decompensated cirrhosis is spontaneous
bacterial peritonitis, the incidence of which can be reduced by primary
or secondary antibiotic prophylaxis by using orally active antibiotics
Major involvement of CD40 in the regulation of chemokine secretion from human peritoneal mesothelial cells
No full textMajor involvement of CD40 in the regulation of chemokine secretion from human peritoneal mesothelial cells.BackgroundCD40 is a member of the tumor necrosis factor (TNF) family of receptors, whose ligand, CD154, is expressed by activated mononuclear cells. CD40 activation is a major immune regulatory pathway and is important for the regulation of chemokine and cytokine secretion. This study investigates the effect of CD40 ligation on the secretion of chemokines from human peritoneal mesothelial cells (HPMC).MethodsWe activated CD40 in HPMC along with combinations of TNF-α, interleukin-1 (IL-1), and interferon gamma (IFN-γ), and evaluated the mRNA levels and protein secretion of regulated upon activation, normal T-cell expressed and secreted (RANTES), monocyte chemoattractant protein-1 (MCP-1), and IL-8.ResultsCD40 ligation had a small stimulatory effect on the secretion of all three chemokines, while TNF-α, IL-1 and IFN-γ induced their secretion in a dose-dependent manner. The combination of CD40 ligation with either IL-1 or TNF-α increased chemokine secretion additively. IFN-γ and CD40 ligation acted in synergy to induce the secretion of the mononuclear recruiting chemokines RANTES and MCP-1 (up to ∼36-fold and ∼ threefold, respectively), for which the combination of all three cytokines with CD40 ligation was extremely potent. In contrast, the secretion of the neutrophil chemoattractant IL-8, induced by CD40 ligation or by the combination of IL-1 and TNF-α, was reduced in the presence of IFN-γ.ConclusionIn light of our data, it is reasonable to suggest that in the mononuclear phase of peritonitis, IFN-γ and CD154, expressed by activated mononuclear cells, diminish IL-8 secretion from HPMC and thus inhibit neutrophil recruitment. At the same time, the two act in synergy to induce the secretion of RANTES and MCP-1 from HPMC. Hence, by regulating chemokine secretion, CD40 may be involved in peritonitis and in the development of late phase mononuclear predominance
Accessory role of human peritoneal mesothelial cells in antigen presentation and T-cell growth
No full textAccessory role of human peritoneal mesothelial cells in antigen presentation and T-cell growth.BackgroundTo assess the role of human peritoneal mesothelial cells (HPMCs) in the generation of an immune response during peritonitis, we tested their ability to activate T-cells by antigen presentation (AP) and by the secretion of interleukin-15 (IL-15). IL-15 is a potent leukocyte activator that stimulates the proliferation of CD4+, CD8+, and B and natural killer (NK) cells.MethodsHPMCs and mononuclear cells were derived from six volunteer patients who underwent elective abdominal surgery. Flow cytometry was used to analyze human lymphocyte antigen-DR (HLA-DR), intercellular adhesion molecule-1 (ICAM-1), and B7 molecules on HPMCs. Affinity-purified CD4 cells were used for AP assays. We used a specific enzyme-linked immunosorbent assay to detect interferon-γ (IFN-γ), IL-2, and IL-15 protein and reverse transcription-polymerase chain reaction for mRNA analysis.ResultsHPMCs expressed HLA-DR molecules following IFN-γ treatment. ICAM-1 molecules were expressed at high levels, and B7-1 and B7-2 molecules could not be detected. The accessory function of HPMCs was assayed by T-cell stimulation using anti-CD3 antibodies (OKT3). HPMCs were essential for a significant OKT3-induced T-cell proliferation. Anti–ICAM-1 antibodies blocked OKT3-induced proliferation. HPMCs served as effective antigen-presenting cells when Tetanus toxoid (TT) or Staphylococcus aureus-α-toxin were used as antigens. IFN-γ, IL-2, and IL-15 accumulated during AP reactions. We found that IL-15 is produced by HPMCs, and IFN-γ up-regulated its mRNA levels and protein secretion in a dose-dependent manner. We also detected IL-15 in the peritoneal effluent of patients undergoing continuous peritoneal dialysis treatment. In patients suffering from peritonitis, IL-15 levels were elevated (35.0 ± 6.0 pg/mL, N = 10) as compared with noninfected patients (16.2 ± 4.0 pg/mL, N = 7).ConclusionsHPMCs participate in the peritoneal immune response against invading pathogens by AP. For this process, ICAM-1 is the major accessory molecule. In addition, HPMCs may contribute to T-cell activation by secretion of IL-15
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