39,233 research outputs found
Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery
No full textCopyright @ 2014 Booth et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.When the nucleolus disassembles during open mitosis, many nucleolar proteins and RNAs associate with chromosomes, establishing a perichromosomal compartment coating the chromosome periphery. At present nothing is known about the function of this poorly characterised compartment. In this study, we report that the nucleolar protein Ki-67 is required for the assembly of the perichromosomal compartment in human cells. Ki-67 is a cell-cycle regulated protein phosphatase 1-binding protein that is involved in phospho-regulation of the nucleolar protein B23/nucleophosmin. Following siRNA depletion of Ki-67, NIFK, B23, nucleolin, and four novel chromosome periphery proteins all fail to associate with the periphery of human chromosomes. Correlative light and electron microscopy (CLEM) images suggest a near-complete loss of the entire perichromosomal compartment. Mitotic chromosome condensation and intrinsic structure appear normal in the absence of the perichromosomal compartment but significant differences in nucleolar reassembly and nuclear organisation are observed in post-mitotic cells
Letter from Carl Hayden to Henry F. Ashurst
No full textLetter describing three enclosures, a letter from F. M. Gold, Carl T. Hayden's reply to Gold's letter, and a copy of a bill introduced by Cameron
Letter from A. F. Potter to Carl Hayden
No full textLetter from A. F. Potter to Carl T. Hayden describing John H. Page's request to build a railway for the Canyon Copper Company as "impractical"
Conflicting orthographic and phonological information results in larger brain activation differences for developmental dyslexics.
No full textDNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
No full textThe majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets. Our strategy uses DNA fusion vaccines to activate high levels of peptide-specific CTL. Key foreign sequences from tetanus toxin activate tolerance-breaking CD4+ T cell help. Candidate MHC class Ibinding tumor peptide sequences are fused to the C terminus for optimal processing and presentation. To model performance against a leukemia-associated antigen in a tolerized setting, we constructed a fusion vaccine encoding an immunodominant CTL epitopederived from Friend murine leukemia virus gag protein (FMuLVgag) and vaccinated tolerant FMuLVgag-transgenic (gag-Tg) mice. Vaccination with the construct induced epitopespecificIFN-c-producing CD8+ T cells in normal and gag-Tg mice. The frequency and avidity of activated cells were reduced in gag-Tg mice, and no autoimmune injury resulted. However, these CD8+ T cells did exhibit gag-specific cytotoxicity in vitro and in vivo. Also, epitope-specific CTL killed FBL-3 leukemia cells expressing endogenous FMuLVgag antigen and protected against leukemia challenge in vivo. These results demonstrate a simple strategy to engage anti-microbial T cell help to activate epitope-specific polyclonal CD8+ T cell responses from a residual tolerized repertoire
Elaboration on Kwapien's theorem: Representing bounded mean zero functions f as coboundary f = g ◦ T − g
No full textIn [8] Kwapien proved that every mean zero function f ∈ L∞[0, 1] we can write as f = g ◦ T − g for some g ∈ L∞[0, 1] and some measure preserving transformation T of [0, 1]. However, as was discovered in [4] there is a gap in the proof for the case that f is not continuous. The aim of this bachelor thesis is filling in that gap in the proof. We first extend Kwapien’s proof for continuous functions to certain other measure spaces. Thereafter, we use the method of proof suggested by Kwapien, to proof the theorem for mean zero function f ∈ L∞[0, 1] for which λ(f−1({x})) = 0 for all x ∈ R. Using this result we then proof that every mean zero function f ∈ L∞[0, 1] can be written as a sum f =(g1 ◦ T1 − g1) + (g2 ◦ T2 − g2) where g1, g2 ∈ L∞[0, 1] and where T1, T2 are measure preserving transformations of [0, 1]. We finish this thesis with an application of Kwapien’s theorem in the study to singular traces Applied Mathematic
f(G,T) and its Cosmological Implications
No full textA coupled formulation of the Gauss-Bonnet invariant term G and the
energy momentum trace T term provide a modified f(G,T) gravity,
has been analyzed in this study. The functional form for the
f(G,T) gravity has been taken as f(G,T)=αT+ βGThe presentation of the authors' names and (or) special characters in the title of the pdf file of the accepted manuscript may differ slightly from what is displayed on the item page. The information in the pdf file of the accepted manuscript reflects the original submission by the author
Bianchi type-I universe in f(R, T) modified gravity with quark matter and Λ
No full text32nd International Physics Congress of Turkish-Physical-Society (TPS) -- SEP 06-09, 2016 -- Bodrum, TURKEYIn this study, we investigate homogeneous and anisotropic Bianchi type I universe in the presence of quark matter source in f (R, T) gravity (Harko et al. in Phys. Rev. D 84:024020, 2011) with cosmological constant A (where R is the Ricci scalar and T is the trace of the energy momentum tensor). For this aim we have used the anisotropy feature of Bianchi type I universe and equation of states (EoS) of quark matter. We explore the exact solution f(R, T)=R + 2f(T) model for Bianchi type I universe model. When t -> infinity, we get very small cosmological constant value, this result agrees with recent observations.Turkish Phys So
Memorial service at the grave of Patrick F. Healy, S.J., in the Jesuit Community Cemetery at Georgetown University
No full textMembers of the Georgetown community gathered at the grave of Patrick F. Healy, S.J. (1834-1910) in the Jesuit cemetery on March 27, 1974 for a memorial service. Fr. Healy's weathered grave had been restored by the Patrick Healy Commemorative Committee, established by the University president to observe the 100th anniversary of Fr. Healy's appointment as Georgetown president in 1874. C.L. Stankiewicz, S.J. (far right), rector of the Jesuit Community, and Joseph T. Durkin, S.J. (second right), member of the Committee, conducted the service.Repository: Booth Family Center for Special Collections. For more information about this collection please email: [email protected]
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