3,153 research outputs found
Bub1 maintains centromeric cohesion by activation of the spindle checkpoint.
Get PDFBub1 is a component of the spindle assembly checkpoint (SAC), a surveillance mechanism that ensures genome stability by delaying anaphase until all the chromosomes are stably attached to spindle microtubules via their kinetochores. To define Bub1's role in chromosome segregation, embryogenesis, and tissue homeostasis, we generated a mouse strain in which BUB1 can be inactivated by administration of tamoxifen, thereby bypassing the preimplantation lethality associated with the Bub1 null phenotype. We show that Bub1 is essential for postimplantation embryogenesis and proliferation of primary embryonic fibroblasts. Bub1 inactivation in adult males inhibits proliferation in seminiferous tubules, reducing sperm production and causing infertility. In culture, Bub1-deficient fibroblasts fail to align their chromosomes or sustain SAC function, yielding a highly aberrant mitosis that prevents further cell divisions. Centromeres in Bub1-deficient cells also separate prematurely; however, we show that this is a consequence of SAC dysfunction rather than a direct role for Bub1 in protecting centromeric cohesion
The author as the second translator
Get PDFParafrazując tytuł tekstu Anny Legeżyńskiej „Tłumacz jako drugi autor” (1999: 20–30), w niniejszym artykule zwracam uwagę na rolę kontaktu z autorem w procesie tworzenia przekładu. Konsultowanie z twórcą oryginału niektórych rozwiązań translatorskich redukuje wątpliwości interpretacyjne widziane z pozycji tłumacza, autorowi zaś daje możliwość zobaczenia swojego tekstu z perspektywy drugiego języka.Paraphrasing the title of Anna Legeżyńska’s text “The translator as the second author” (1999: 20–30), this paper focuses on the role of contact with the author in the translation process. Discussions with the author on certain translation solutions reduce interpretative doubts as seen from the perspective of the translator, while the author is given an opportunity to see his or her text from the perspective of another language. In this text I am referring and quoting selected examples that were included in the letters exchanged with Konstantin Arbienin, the author of “Sleepless Stories” (Сказки на засыпку) whose translation has become the basis for making an audiobook. The project was launched within the activity framework of ‚Perevodka’, a translation section of the Research Association of the Department of Russian Studies at the NCU in cooperation with our friends musicians and graphic artists
Correlating endoplasmic reticulum stress with the onset of disease phenotype in chondrodysplasias
No full textCharacterisation of genes expressed during the early stages of VEGF-induced angiogenesis
No full textMutant chondrocytes are characterised by altered cell shape and changes to the organisation of primary cilia in a genetic mouse model of mild pseudoachondroplasia
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Characterisation of genes expressed during the early stages of VEGF-induced angiogenesis
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Characterisation of genes down-regulated during the depostion of a mineralised matrix by pericytes in vitro
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