2 research outputs found
Anticancer effect of Vitex negundo Linn. (Verbenaceae) on MCF-7 Breast Cancer Cells and Its Antimicrobial Properties
No full textBreast cancer treatment presents significant challenges, with various therapeutic modalities often associated with side effects. Natural plant-derived compounds offer promising alternatives. Vitex negundo is a medicinal plant often used in ayurvedic medicine to treat a variety of ailments, some of which have been scientifically validated. Vitex negundo offers a potential natural alternative to conventional breast cancer treatments. In this context, Vitex negundo ethanolic extract has demonstrated to have potent activity against the breast cancer cell line MCF-7. Vitex negundo extracts expressed a dose-dependent cytotoxic effect against MCF-7, with increasing extract concentrations correlating to decreased cell viability. Notably, the extract selectively suppressed MCF-7 cell growth, with an inhibitory concentration of about 1000 μg/mL. Importantly, the extract appears to selectively target cancer cells, sparing normal, healthy cells. This selectivity is crucial for minimizing side effects often associated with conventional cancer treatments. Vitex negundo serves as a potential indigenous antimicrobial agent that has been evaluated by the paper disc method to identify microorganisms susceptible to the ethanolic extract. The results based on the well-diffusion method confirmed the extracts of antimicrobial activity against sensitive microorganisms
Exposure to polycyclic aromatic hydrocarbons with special focus on cancer
No full textABSTRACTPolycyclic aromatic hydrocarbons (PAHs) are a group of compounds consisting of two or more fused aromatic rings. Most of them are formed during incomplete combustion of organic materials such as wood and fossil fuels, petroleum products, and coal. The composition of PAH mixtures varies with the source and is also affected by selective weathering effects in the environment. PAHs are ubiquitous pollutants frequently found in a variety of environments such as fresh water and marine sediments, the atmosphere, and ice. Due to their widespread distribution, the environmental pollution due to PAHs has aroused global concern. Many PAHs and their epoxides are highly toxic, mutagenic and/or carcinogenic to microorganisms as well as to higher forms of life including humans. The main aim of this review is to provide contemporary information on PAH sources, route of exposure, worldwide emission rate, and adverse effects on humans, especially with reference to cancer
