170,094 research outputs found

    Después de la caída del ‘ángel’. Un escritor argentino olvidado. Ángel Bonomini

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    Ángel Bonomini (1929-94), erede della tradizione fantastica argentina, fu uno scrittore prolifico la cui produzione comprende racconti, saggi e poesie. Pur vivendo in un periodo di splendore culturale, cadde nell\u27oblio quasi totale, scomparendo molto presto dalla scena letteraria contemporanea. Le sue prime poesie sono state trovate, a partire dagli anni \u2750, nella rivista Sur e alcuni dei suoi racconti sono stati inclusi in note antologie di letteratura fantastica. Nel genere fantastico che caratterizza la sua narrativa, c\u27è un contrasto permanente tra metafisica ed esistenzialismo, nel desiderio di indagare a fondo la realtà ma al contempo di superarla. Ángel Bonomini (1929-94), heredero de la tradición fantástica argentina, fue un escritor prolífico cuya producción comprende relatos, ensayos y poemas. Aún viviendo en un período de esplendor cultural cayó en un casi total olvido, desapareciendo muy pronto del panorama literario a él contemporáneo. Sus primeros poemas se encuentran, a partir de la década de los años cincuenta, en la revista Sur y algunos de sus relatos fueron incluidos en notorias antologías de la literatura fantástica. En el particular fantástico que caracteriza su narrativa se advierte una permanente contraposición entre la metafísica y el existencialismo, en una voluntad de indagar profundamente la realidad pero al mismo tiempo ir más allá de ella.Ángel Bonomini (1929-94), erede della tradizione fantastica argentina, fu uno scrittore prolifico la cui produzione comprende racconti, saggi e poesie. Pur vivendo in un periodo di splendore culturale, cadde nell\u27oblio quasi totale, scomparendo molto presto dalla scena letteraria contemporanea. Le sue prime poesie sono state trovate, a partire dagli anni \u2750, nella rivista Sur e alcuni dei suoi racconti sono stati inclusi in note antologie di letteratura fantastica. Nel genere fantastico che caratterizza la sua narrativa, c\u27è un contrasto permanente tra metafisica ed esistenzialismo, nel desiderio di indagare a fondo la realtà ma al contempo di superarla. Ángel Bonomini (1929-94), heredero de la tradición fantástica argentina, fue un escritor prolífico cuya producción comprende relatos, ensayos y poemas. Aún viviendo en un período de esplendor cultural cayó en un casi total olvido, desapareciendo muy pronto del panorama literario a él contemporáneo. Sus primeros poemas se encuentran, a partir de la década de los años cincuenta, en la revista Sur y algunos de sus relatos fueron incluidos en notorias antologías de la literatura fantástica. En el particular fantástico que caracteriza su narrativa se advierte una permanente contraposición entre la metafísica y el existencialismo, en una voluntad de indagar profundamente la realidad pero al mismo tiempo ir más allá de ella.Ángel Bonomini was born in Buenos Aires in 1929 where he lived until his death at the age of sixty-four in 1994. He worked for various newspapers and magazines as an art critic and translator, but always maintaining his literary activity. He inherited the tradition of the Argentine fantastic and was a prolific writer: his production includes essays, poems and fantastic tales. Although he lived in a period of great cultural splendor and his literary talent was recognised by authors such as Borges and Bioy Casares, he fell into an unexplained oblivion, disappearing quite early from the contemporary intellectual environment. His first poems, which date back to the 1950s, were published in Sur magazine and some of his tales were included in well-known anthologies of fantastic literature. Among his collections of poems there are: Primera enunciación (1947), Argumento del enamorado. Baladas con Ángel (1952) written with María Elena Walsh, Torres para el silencio (1982) and Poética (1994). In 1972 he achieved great success with the publication of his first collection of fantastic tales, Los novicios de Lerna, followed by the publication of other books: Libro de los casos (1975), Los lentos elefantes de Milán (1978), Cuentos de amor (1982), Historias secretas (1985) and Más allá del puente (1996), posthumously published. A particular use of the fantastic characterises his work and distinguishes him from his contemporary authors. In his tales there is a continuous contrast between metaphysics and existentialism; in this way, he makes a deep investigation of the reality and, at the same time, he tries to go beyond it. This volume aims to analyse some emblematic tales by Bonomini in which it is possible to find the main topoi of Argentine fantastic and to understand why the author’s literary work is worth studying

    Mitochondrial dysfunction in skeletal muscle of a fibromyalgia model: The potential benefits of melatonin

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    Fibromyalgia syndrome (FMS) is considered a musculoskeletal disorder associated to other symptoms including chronic pain. Since the hypothesis of FMS etiogenesis is consistent with mitochondrial dysfunction and oxidative stress, we evaluated the pathophysiological correlation among these factors studying some proteins involved in the mitochondrial homeostasis. We focused our attention on the roles of peroxisome proliferator activated receptor gamma coactivator-1alpha (PGC-1α), mitofusin2 (Mfn2), and coenzyme Q10 (CoQ10) in reserpine-induced myalgic (RIM) rats that manifest fibromyalgia-like chronic pain symptoms. First, we underlined that RIM rats are a good model for studying the pathophysiology of FMS and moreover, we found that PGC-1α, Mfn2, and CoQ10 are involved in FMS. In fact, their expressions were reduced in gastrocnemius muscle determining an incorrect mitochondrial homeostasis. Today, none of the currently available drugs are fully effective against the symptoms of this disease and they, often, induce several adverse events; hence, many scientists have taken on the challenge of searching for non-pharmacological treatments. Another goal of this study was therefore the evaluation of the potential benefits of melatonin, an endogenous indoleamine having several functions including its potent capacity to induce antioxidant enzymes and to determine the protective or reparative mechanisms in the cells. We observed that melatonin supplementation significantly preserved all the studied parameters, counteracting oxidative stress in RIM rats and confirming that this indoleamine should be taken in consideration for improving health and/or counteract mitochondrial related diseases
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