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Nose-to-brain delivery
No full textNose-to-brain delivery represents a big challenge. In fact there is a large number of neurological diseases that require therapies in which the drug must reach the brain, avoiding the difficulties due to the blood–brain barrier (BBB) and the problems connected with systemic administration, such as drug bioavailability and side-effects. For these reasons the development of nasal formulations able to deliver the drug directly into the brain is of increasing importance. This Editorial regards the contributions present in the Special Issue “Nose-to-Brain Delivery”
Composizioni farmaceutiche a base di zeoliti contenenti zinco ed eritromicina da impiegare nella terapia anti-acne
No full textZeolites in biomedical application: Zn-exchanged clinoptilolite-rich rock as active carrier for antibiotics in anti-acne topical therapy
No full textThe combination of erythromycin and zinc in the topical antibiotic therapy of acne has been proved useful to reduce the development of antibiotic-resistant strains. An Italian zeolite-rich rock, containing 66 wt.% of clinoptilolite, has been used to prepare an active carrier for erythromycin. The zeolite has been conditioned in zinc form by a set of cation exchange processes, then erythromycin has been adsorbed onto the micronized rock by vacuum drying. After 6 month ageing, almost 95% of the loaded drug was found, indicating good stability of the Zn-carrier-erythromycin system. Minimum inhibitory concentration (M.I.C.) assay on Propionibacterium acnes showed that the process of adsorption of erythromycin does not affect its antimicrobial activity. Both drug and zinc release were evaluated from the carrier powder: the erythromycin release was more than 80% in the first hour and independent on hydrodynamic conditions (United States Pharmacopoeia dissolution apparatus or Franz cell). The release of zinc was fast. and more dependent on the hydrodynamic conditions. The influence of formulating the carrier by dispersion in two anhydrous bases, an absorption petrolatum base (HP) and a water soluble polyethylenglycol base (PEG), was evaluated. In both cases erythromycin and zinc showed a release quantitatively similar to that of the powder, although the release rate was slightly lower from the more hydrophobic HP base
Pharmaceutical zeolite-based compositions containing zinc and erythromycin, to be used in the treatment of acne
No full textZeolites in biomedical applications: Zn-exchanged clinoptilolite-rich rock as active carrier for antibiotics in anti-acne topical therapy
No full textUse of a Zn-exchanged clinoptilolite-bearing material as an active carrier for erythromycin to be used in anti-acne therapy
No full textZeolites in biomedical application: Zn-exchanged clinoptilolite-rich rock as active carrier for antibiotics in anti-acne topical therapy
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