2,040 research outputs found
Preparation and Catalytic Enantioselective Reactions of C3-Symmetric Tris(Oxazoline)s Derived from Kemp's Triacid
No full textSimple Synthesis of Enantiomerically Pure C2-Symmetric Bisoxazolidines from Amino Alcohols and Formaldehyde
No full textNH-functionalization of sulfoximines by using hypervalent iodine reagents
No full textSince 2016, the preparation and reactivity of sulfoximidoyl-containing hypervalent iodine reagents were well investigated by Bolm group, and they also demonstrated that such reagents can serve as electrophilic sulfoximidoyl source or sulfoximidoyl radicals to modify existing structures. In this thesis, we devised a metal-free approach toward α-ketoamides by reacting hypervalent iodine reagents with arylalkynes/cyanoacetates in presence of light/ base. Then, we developed an efficient photocatalytic fluoro and sulfoximidation of alkenes using p-TolIF2 and sulfoximines under the visible light. The protocol tolerates a broad range of styrenes and sulfoximines with highly chemoselective and affords difunctionalized products in good to excellent yields. In the absence of styrene and photocatalysis, an unexpected N-chloro-substituted and N-bromo sulfoximine were found in the reaction of p-TolIF2 and sulfoximines with dichloromethane or dibromomethane under blue LEDs. In addition, we studied the accessibility of the difluoroacetoxy and sulfoximidoyl-containing hypervalent iodine reagents, and we introduced such reagents into difunctionalisation of styrenes leading to product with a sulfoximidoyl group and a difluoroacetate group with highly chemoselective
Correction to: When terminology hinders research: the colloquialisms of transitions of control in automated driving (Cognition, Technology & Work, (2022), 10.1007/s10111-022-00705-3)
Full text linkIn the original article, author affiliation published with error. The correct affiliations are: Davide Maggi—Institute for Transport Studies, Leeds, UK. Richard Romano—Institute for Transport Studies, Leeds, UK. Oliver Carsten—Institute for Transport Studies, Leeds, UK. Joost C. F. De Winter—Faculty of Mechanical, Maritime and Materials Engineering, Delft University of Technology, Delft, The Netherlands. The original article has been corrected.Human-Robot Interactio
Conferencia: 'Sulfoximines: Syntheses and applications in asymmetric catalysis'
No full textConferencia: 'Sulfoximines: Syntheses and applications in asymmetric catalysis', a cargo de Carsten Bolm. RWTH Aachen. Germany. Paraninfo. Campus de la Merced
Studies on the Zinc-mediated Phenyl and Alkynyl addition to Carbon-heteroatom double bonds
No full textThis thesis describes the work carried out by the author in the field of enantioselective dialkylzinc-mediated carbon-carbon bond forming reactions. In particular, the asymmetric addition of C(sp2) and C(sp) nucleophiles to carbon-heteroatom double bonds was the subject of this research. In the first part of the thesis, the synthesis of new chiral compounds to be used as ligands for the enantioselective phenyl addition to aldehydes is described. Novel alfa-hydroxy oxazolines derived from such precursors as mandelic acid, benzoylformic acid and ethyl oxamate were synthesized and used as chiral promoters for the reaction of a mixture of triphenylborane and diethylzinc with aromatic and aliphatic aldehydes. As a result, chiral secondary alcohols were obtained in good yields with up to 81% enantiomeric excess. In the second part of this work, the synthesis of propargylic amines by the reaction of a mixture of a terminal acetylene and dimethylzinc with imines was developed. Whereas it was found that the reaction can proceed also in the absence of ligands, providing an easy and high yielding way to prepare racemic propargylamines, the addition to the reaction mixture of a tertiary amino alcohol, having a norephedrine-based structure, as a chiral promoter allowed to obtain the products in good to high yields with up to 97% ee
Mechanochemical Activation of Iron Cyano Complexes: A Prebiotic Impact Scenario for the Synthesis of α-Amino Acid Derivatives
No full textMechanochemical activation of iron cyano complexes by ball milling results in the formation of HCN, which can be trapped and incorporated into alpha-aminonitriles. This prebiotic impact scenario can be extended by mechanochemically transforming the resulting alpha-aminonitriles into alpha-amino amides using a chemical route related to early Earth conditions
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