1,721,035 research outputs found
6q27 contains candidate genes involved in surface epithelial ovarian tumors. 4th congress of the European Society for Gynecologic and Obstetric Investigation, Madonna di Campiglio, 14-20 marzo, 1999
No full textNatural history of cervical intraepithelial neoplasia during pregnancy
No full textObjective. It is uncertain whether pregnancy influences the natural history of cervical intraepithelial neoplasia (CIN). Our aim was to evaluate the evolution of CIN in pregnant women. Design. Prospective study. Setting. Department of Obstetrics and Gynaecology, University of Insubria, Italy. Population. Women with histological CIN during pregnancy. Methods and main outcome measures. Between 2003 and 2007, women with an abnormal Pap-smear during pregnancy underwent colposcopy. Patients with histological CIN were followed during pregnancy with colposcopy every 8 weeks and post-partum evaluation was scheduled 3-6 months after delivery. Women with post-partum histological diagnosis of CIN 2-3 underwent conization. To understand the impact of pregnancy on the evolution of CIN, women with CIN 1 discovered during pregnancy were compared to a group of non-pregnant fertile patients with first diagnosis of CIN 1. Results. A total of 78 women were included: 36 (46.2%) with CIN 2-3 and 42 (53.8%) with CIN 1. In women with CIN 2-3, no invasion was suspected during pregnancy and at post-partum evaluation, no invasive or microinvasive cancer, and 19 (52.7%) persistent CIN 2-3, and 17 (47.3%) regressions were diagnosed. In the group of CIN 1, we recorded six (14.3%) progressions to CIN 2-3, seven (16.6%) persistent CIN 1 and 29 (69%) regressions. The control group of non-pregnant women had a lower regression rate (37/76: 48.7%) in comparison to pregnant women (p=0.03). Conclusions. Expectant management for CIN 2-3 diagnosed during gestation is safe. When discovered during pregnancy, CIN 1 has a significantly higher tendency to spontaneous regression in comparison to non-pregnant condition
Lymphocytotoxic antibodies in human pregnancy: detection of their presence in the first trimester
No full textImmunogenetic profiles of mothers and maternal response of fetal MHC antigens
No full textWe studied the genetic predisposition of mothers to producing cytotoxic antibodies against the HLA antigens of the fetus and the biological significance of this phenomenon, by investigating 250 mothers and 30 repetitive aborters for HLA polymorphisms (class I, II, properdin factor B) and for immunoglobulin allotypes (Gm and Km). We subdivided the mothers, into antibody positive and antibody negative groups by testing their sera against a large panel of T and B enriched suspensions. None of the women who had miscarried produced anti-fetus cytotoxic antibodies. The frequency of the antigen DR3 in antibody negative mothers and of DR5 in antibody positive ones was increased. The typing of factor B (serum complement protein) demonstrated an association between the genetic predisposition to respond to fetal MHC antigens and the F variant
Female Psychopathologic profile during menopausal transition: A preliminary study
No full textObjectives: To evaluate the psychopathological profile and the incidence of major depressive disorders in consecutive women
attending a Menopause Clinic.
Methods: Women attending outpatient menopause clinic at Filippo del Ponte Hospital in Varese (Italy), referring to the centre
from 1 March to 30 April 2005, were invited to fill up a specific questionnaire while waiting for the visit. The questionnaire
included demographics and history (e.g. current or past use of antidepressant drugs); symptoms check list (SCL-90-R); Beck
depression inventory (BDI).
Results: Sixty-four women were enrolled to the study. On the SCL-90-R, “somatic” symptoms cluster was the most frequent.
Patients diagnosed as depressed using the Beck depression inventory (BDI) were 18 (28.1%). Thirteen (70%) of currently
depressed women presented a positive history of depressive disorders. The analysis of depressed women according to previous
depressive disorders revealed higher scores for women with positive history in both scales. Depressed patients have a significantly
lower mean age compared to non-depressed patients (53.3 ± 6.2 years versus 57.33 ± 4.9 years, p = 0.023).
Conclusions: Our preliminary data show a high correlation between a history of depressive disorder and recurrence of depression
in the menopausal period. Perimenopause seems to be a higher risk period for the development of a depressive disease compared
to menopausal status. The somatization cluster warrants further investigatio
Lymphocytotoxic antibodies in human pregnacy: detection of their presence in the first trimester
No full textsera of pregant women were tested for their reactivity against PHA activated lymphocytes from HLA typed blood donors.Our data suggest that during the first three months of the first pregnancy, there is an intensive humoral maternal response, even higher than in the subsequent trimester, and in subsequent pregnancies. Nevertheless there is evidence that these cytotoxic antibodies do not react with defined HLA determinants
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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