1,721,046 research outputs found
Reproducibility and transportability of the absence of incremental infectious adverse events in patients with higher anti-TNF drug levels
No full textErratum: Impact of evidence-based medicine on the treatment of patients with unresectable hepatocellular carcinoma (Alimentary Pharmacology and Therapeutics (2010) 31 (493-501))
No full textEditorial: Challenges in inflammatory bowel disease: current, future and unmet needs, volume II
No full textCrushed corticosteroid tablets in peristomal pyoderma gangrenosum: A case report
No full textBACKGROUND: Peristomal pyoderma gangrenosum (PPG) is a variant of pyoderma gangrenosum (PG). It results from a pathergy response to trauma from effluent from the ostomy or secondary to trauma caused by removal of the ostomy appliance adhesive in contact with the skin. Currently, no evidence-based guidelines for the management of PPG exist. This case study reports a dramatic response to crushed corticosteroid tablets in a patient who proved refractory to first- and second-line treatments of her PPG and several surgeries. CASE: Ms T. was a 39-year-old woman with Crohn's disease who underwent several ileostomies, developed PPG, and failed treatment with adalimumab. Her PPG was successfully treated topically with crushed prednisone tablets. CONCLUSION: We found that crushed corticosteroid tablets were an effective treatment of PPG, due to the ability to reduce pain and allow adhesion of the ostomy appliance
Prevention of Crohn's Disease Recurrence After Surgery: On the Road to Recovery.
No full textDear Editors,
we have read with interest the paper by Regueiro et al (1) regarding long term Infliximab (IFX) use as maintenance therapy to prevent Crohn’s disease (CD) recurrence after ileo-colonic resection. This study is the continuation of a previous randomized, two armed trial, that evaluated the rate of endoscopic recurrence at one year after surgery, in patients randomized to IFX or placebo. The proportion of endoscopic recurrence was lower in the IFX group compared with placebo (9% vs. 85%) (2). In the current open-label study, the same patients, according to their endoscopic findings at one year, were given the option to continue, to stop, or to start IFX therapy. Then patients were followed for at least 5 years after surgery. Patients on long-term IFX therapy, irrespective of original assignment to IFX or placebo, presented higher rate of endoscopic remission and lower rate of surgical recurrence compared with other patients during the whole follow-up period. These data are important because confirm that starting anti-TNFα immediately after surgery (3-5) or shortly after endoscopic recurrence (6-7) permits to obtain a low recurrence rate in the long-term. Moreover, the Authors demonstrated that early anti-TNFα treatment is associated to a lower need for additional surgery compared to patients who started the treatment in response to endoscopic recurrence.
This study is particularly relevant considering the paucity of data currently available in medical literature on the role of anti-TNFα drugs in the post-surgical setting. However, not all the data available in literature have been quoted as we have recently published the first randomized three armed study evaluating the rate of endoscopic recurrence at two years follow-up in patients treated with Adalimumab (ADA), azathioprine or mesalamine. Also in our study, the rate of endoscopic recurrence was significantly lower in ADA group compared with azathioprine and mesalamine, (6.3% vs. 64.7% vs. 83.3%, respectively (8). Moreover, we provided a follow-up period of two years with detailed clinical, radiologic and endoscopic data at 1 and 2 years after surgery and, further, we directly compared the anti-TNFα treatment with the most traditional drugs, such as mesalamine and azathioprine.
Therefore our data and those published by Regueiro et al confirm that patients with risk factors for disease recurrence and additional surgery, such as cigarette smoking, young age, ileocolonic involvement, penetrating/fistulizing disease behavior, early immunomodulator administration and short disease duration before surgery should be considered to start treatment with anti TNFα shortly after surger
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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