194,110 research outputs found
De Bonis Angelis Dei Filiis Commentatio : Programma S. Archangeli Michaelis Festo A. R. S. MDCCLXIV. In Academia Ivlia Carolina P. P. / [Christoph August Bode]
No full textHelmstedt, Univ., Programm, 1764Vermutl. Verf. ermittelt nach: WBIS, DBA, I 113,147. Lt. Einträgen in WBIS veröffentlichte Christoph August Bode 1760 "De Bonis Angelis Dei Filiis"Vorlageform des Erscheinungsvermerks: Helmstadii Typis Vid. P. D. Schnorrii Acad. Typogr
Reassessing the BODE score as a criterion for listing COPD patients for lung transplantation.
No full textBACKGROUND: The BODE score (incorporating body mass index, airflow obstruction, dyspnea and exercise capacity) is used for the timing of listing for lung transplantation (LTx) in COPD, based on survival data from the original BODE cohort. This has limitations, because the original BODE cohort differs from COPD patients who are candidates for LTx and the BODE does not include parameters that may influence survival. Our goal was to assess whether parameters such as age, smoking status and diffusion indices significantly influence survival in the absence of LTx, independently of the BODE.
METHODS: In the present cohort study, the BODE was prospectively assessed in COPD patients followed in a tertiary care hospital with an LTx program. The files of 469 consecutive patients were reviewed for parameters of interest (age, gender, smoking status and diffusing capacity of the lungs for carbon monoxide [DL,CO]) at the time of BODE assessment, as well as for survival status. Their influence on survival independent of the BODE score was assessed, as well as their ability to predict survival in patients aged less than 65 years.
RESULTS: A Cox regression model showed that the BODE score, age and DL,CO were independently related to survival (P-values <0.001), as opposed to smoking status. Survival was better in patients aged less than 65 in the first (P=0.004), third (P=0.002) and fourth BODE quartiles (P=0.008). The difference did not reach significance in the second quartile (P=0.13). Median survival for patients aged less than 65 in the fourth BODE quartile was 55 months. According to a receiver operating characteristic curve analysis, the BODE score as well as FEV1 and DL,CO fared similarly in predicting survival status at 5 years in patients aged less than 65 years.
CONCLUSION: Age and DL,CO add to the BODE score to predict survival in COPD. Assessing survival using tools tested in cohorts of patients younger than 65 years is warranted for improving the listing of patients for LTx
Modified BODE indexes: Agreement between multidimensional prognostic systems based on oxygen uptake
No full textJos&eacute; Luis Lopez-Campos, Pilar Cejudo, Eduardo Marquez, Francisco Ortega, Esther Quintana, Carmen Carmona, Emilia BarrotUnidad M&eacute;dico-Quir&uacute;rgica de Enfermedades Respiratorias, Hospitales Universitarios Virgen del Roc&iacute;o, Seville, SpainAim: It has been recently shown that the original BODE index has a high degree of correlation with two modified BODE indexes using maximal oxygen uptake expressed either as mL/min/kg (mBODE) or as the percentage predicted (mBODE%). In this study we investigated the agreement between the two modified BODE indexes (mBODE and mBODE%) in patients with stable chronic obstructive pulmonary disease (COPD).Methods: A total of 169 patients with stable COPD were enrolled in this cross-sectional study. Differences between the two mBODE indexes were assessed using kappa coefficients and Bland-Altman plots. One out of every three patients underwent the six-minute walking test to investigate the agreement with the original BODE index.Results: Correlations between the two mBODE indexes with each other (r = 0.96, P &lt; 0.001) and with the original BODE index (mBODE r = 0.88, P &lt; 0.001; mBODE% r = 0.93, P &lt; 0.001) were excellent. However, the two mBODE indexes were significantly different from each other (mBODE 5.27 &plusmn; 2.3 versus mBODE% 4.31 &plusmn; 2.5; P &lt; 0.001). The kappa coefficients were significantly lower (entire study group k = 0.5, P &lt; 0.001) for every GOLD stage. The mean difference between the two mBODE indexes was 0.8 &plusmn; 0.6 units. Differences with the original BODE were higher for the mBODE (1.8 &plusmn; 0.9) than for the mBODE% (0.6 &plusmn; 0.8).Conclusions: The new mBODE indexes are highly correlated but significantly different from each other. The differences between the novel indexes deserve further scrutiny.Keywords: BODE index, chronic obstructive pulmonary disease, exercise testing, multidimensional evaluation, oxygen uptak
Evaluation of BODE index and its relationship with systemic inflammation mediated by proinflammatory biomarkers in patients with COPD
No full textNaushad Ahmad Khan,1,2 Mradul Kumar Daga,1 Istaq Ahmad,2 Govind Mawari,1 Suman Kumar,3 Naresh Kumar,1 Syed Akhter Husain2 1Department of Medicine, Maulana Azad Medical College, 2Department of Biosciences, Jamia Millia Islamia, 3Department of Microbiology, Maulana Azad Medical College, New Delhi, India Introduction: BODE index, a multidimensional grading system which is based on Body mass index, airway Obstruction, Dyspnea scale, and Exercise capacity, has been increasingly used for the evaluation of chronic obstructive pulmonary disease (COPD). Many of the systemic manifestations of COPD are shown to be mediated by elevated levels of proinflammatory biomarkers.Objective: We aimed to investigate the relationship between the BODE index, its components, disease severity, and proinflammatory biomarkers like C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and interleukin (IL)-6.Materials and methods: A cross-sectional study which included 290 clinically stable COPD patients and 80 smoker controls was conducted. Medical history, body mass index, pulmonary function tests, 6-minute walking test, and modified scale of Medical Research Council dyspnea scale were evaluated. BODE scores were determined. Systemic inflammation was evaluated with the measurement of CRP, TNF-α, and IL-6 in the serum samples of all studied subjects. The correlation between inflammatory biomarkers and BODE index was assessed in COPD patients.Results: We found a significant relationship between COPD stages and BODE index. Our analysis showed significant association between systemic biomarkers and components of the BODE index. Both TNF-α and CRP levels exhibited weak but significant correlation with BODE index. Serum IL-6 concentrations exhibited significant correlation with 6-minute walking test, modified scale of Medical Research Council, and BODE index (r=0.201, P=0.004; r=0.068, P=0.001; and r=0.530, P=0.001, respectively). Also, an inverse and significant correlation was observed between BODE index and FEV1 (r=0.567, P=0.001). IL-6 exhibited a highly significant and inverse correlation with FEV1 (r=−0.580, P=0.001).Conclusion: BODE index should be considered for evaluating patients with COPD. Also, IL-6 seems to be a potential biomarker that may enable determination of the severity and prediction of the course of the disease. Keywords: BODE index, chronic obstructive pulmonary disease, systemic inflammation, biomarker
Denkschrift Auf Bode
No full textDENKSCHRIFT AUF BODE
Denkschrift Auf Bode ( - )
Frontispiece ( - )
P. M. ( - )
Titelseite ( - )
Zitat: Montaigne Th. VI. S. 174. nach Bode's Übersetzung. ( - )
Johann Joachim Christoph Bode ( - )
Erklärung. ( -
Interaktiivinen Bode-diagrammi suodatinsuunnittelun tueksi
No full textTiivistelmä. Bode–diagrammi kuvaa järjestelmän tulo- ja lähtösignaalin välistä vahvistusta ja vaihesiirtoa taajuuden funktiona. Suodatinsuunnittelussa diagrammia voidaan käyttää niin järjestelmän kuvaamisessa kuin sen vaatimusten määrittelyssäkin. Suodattimen siirtofunktio voidaan esittää graafisesti nollanapakartalla, josta taas voidaan määrittää suodatinsysteemin taajuusvaste. Kandidaatintyössä luotiin helppokäyttöinen web-ohjelmoitu Bode-diagrammin esitysmuoto, ottaen vastaan käyttäjän antama siirtofunktio interaktiivisen nollanapakartan avulla ja tuottamalla siitä systeemin taajuusvaste Bode -diagrammina
Adrenomedullin refines mortality prediction by the BODE index in COPD - The "BODE-A" index.
No full textpeer reviewedThe BODE index is well-validated for mortality prediction in COPD. Concentrations of plasma proadrenomedullin, a surrogate for mature adrenomedullin, independently predicted 2-year mortality among inpatients with COPD exacerbation.We compared accuracy of initial proadrenomedullin level, BODE, and BODE components, alone or combined, in predicting 1-year or 2-year all-cause mortality in a multicenter, multinational observational cohort with stable, moderate to very severe COPD.Proadrenomedullin was significantly associated (P<0.001) with 1-year mortality (4.7%) and 2-year mortality (7.8%), and comparably predictive to BODE regarding both (C statistics: 0.691 vs. 0.745, 0.635 vs. 0.679). Relative to using BODE alone, adding proadrenomedullin significantly improved 1-year and 2-year mortality prognostication (C statistics: 0.750, 0.818; both P<0.001). Proadrenomedullin plus BOD was more predictive than was the original BODE including 6-minute-walk distance. In multivariable analysis, proadrenomedullin (LR X2 13.0, P<0.001), body mass index (8.5, P=0.004), and 6-minute-walk distance (7.5, P=0.006), but not modified MMRC dyspnoea score (2.2, P=0.14) or FEV1 % predicted (0.3, P=0.60), independently foretold 2-year survival.Proadrenomedullin plus BODE better predicts mortality in COPD patients than does BODE alone; proadrenomedullin may substitute for 6-minute-walk distance in BODE when 6-minute-walk testing is unavailable
De Bonis Angelis Dei Filiis Commentatio. Programma S. Archangeli Michaelis Festo A. R. S. MDCCLXIV. In Academia Ivlia Carolina P. P / [Verf.: Christoph August Bode]
No full textИндекс BODE и риск остеопоротических переломов у больных хронической обструктивной болезнью легких
No full textThe goal of the study: to define theoretic correlation between BODE index in men with chronic obstructive pulmonary disease (COPD) and risk of osteoporotic fractures assessed as per bone mineral density and FRAX integral rate.Materials and methods. 125 men suffering from COPD smoking for a long period of time (the smoker index of 240 and time of smoking (packs/years) of 40) were included into the study. 10 year risk of osteoporotic fractures was assessed by FRAX software. The respiratory function was evaluated by the multi-module unit of MasterLab/Jaeger type. BODE index was defined in the patients.Results. The minimum level of BODE was observed in those suffering from COPD of the 2nd stage – 2.23 ± 0.88. In case of the 3rd stage of COPD BODE made 5.05 ± 1.19, in the 4th stage of COPD it made 7.0 ± 1.0. The maximum risk of fractures was detected in the patients of the 4th stage of COPD. The minimum risk of fractures was diagnosed in the patients of the 2nd stage of COPD. The confident correlations were found between BODE and bone mineral density (r = -0.71, p < 0.005), as well as confident correlations between BODE and the risk of fractures (r = -0.54, p < 0.05). Conclusions. The correlation has been found between BODE index and the risk of fractures. Цель исследования: теоретическое определение корреляционных связей между индексом BODE у мужчин с хронической обструктивной болезнью легких (ХОБЛ) и риском возникновения у них остеопоротических переломов, оцененных по минеральной плотности костной ткани (МПКТ) и интегральному показателю FRAX.Материалы и методы. Обследовано 125 мужчин с ХОБЛ, имеющих длительный стаж курения (индекс курильщика 240 и стаж курения (пачек/лет) 40). Десятилетний риск остеопоротических переломов оценивали с помощью компьютерной программы FRAX. Исследование функции внешнего дыхания проводили на многомодульной установке типа MasterLab/Jaeger. У больных определяли индекс BODE.Результаты. Минимальный уровень индекса BODE наблюдали у пациентов с ХОБЛ 2-й стадии - 2,23 ± 0,88. При 3-й стадии ХОБЛ BODE составлял 5,05 ± 1,19, при 4-й стадии ХОБЛ - 7,0 ± 1,0. Максимальный риск переломов выявлен у больных ХОБЛ 4-й стадии. Минимальный риск переломов диагностирован у больных ХОБЛ 2-й стадии. Установлены достоверные корреляционные связи BODE с МПКТ (r = -0,71, p < 0,005), достоверные корреляционные связи BODE и риска переломов (r = -0,54, p < 0,05). Выводы. Установлена взаимосвязь между индексом BODE и риском переломов
Fast Identification of Bound Structures in Large N-body Simulations
No full textWe present an algorithm that is designed to allow the efficient identification and preliminary dynamical analysis of thousands of structures and substructures in large N-body simulations. First, we utilize a refined density gradient system (based on denmax) to identify the structures and then apply an iterative approximate method to identify unbound particles, allowing fast calculation of bound substructures. After producing a catalogue of separate energetically bound substructures, we check to see which of these are energetically bound to adjacent substructures. For such bound complex subhaloes, we combine components and check if additional free particles are also bound to the union, repeating the process iteratively until no further changes are found. Thus, our subhaloes can contain more than one density maximum, but the scheme is stable: starting with a small smoothing length initially produces small structures that must be combined later and starting with a large smoothing length produces large structures within which sub-substructure is found. We apply this algorithm to three simulations. Two that are using the TPM algorithm by Bode, Ostriker & Xu and one on a simulated halo by Diemand, Moore & Stadel. For all these haloes, we find about 5–8 per cent of the mass in substructures
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