1,720,982 research outputs found
Anti-oestrogen therapy in the treatment of desmoid tumours. A systematic review
No full textAbstract
AIM:
The treatment of desmoid tumours (DTs) is controversial. Anti-oestrogen therapy has frequently been used, but clear information of its efficacy is lacking. In this systematic review we have undertaken a comprehensive analysis to assess the effectiveness of anti-oestrogen therapy in terms of ability to induce partial or complete regression of DTs.
METHOD:
A systematic review of articles published in English between January 1983 and December 2009 was carried out according to the RECIST criteria. A literature search was performed on electronic databases including: United States National Library of Medicine (MEDLINE-PubMed), Excerpta Medica (EMBASE), Cochrane Library and Google search engine. Two-hundred articles dealing with DTs were identified but only fourty-one were were selected as appropriate for the study. The chi-square test was used for statistical analysis.
RESULTS:
Data on 168 DTs treated with anti-oestrogen agents, alone or in combination with nonsteroidal anti-inflammatory drugs, were identified with an overall response rate of 51%. There was no difference in response according to the type of DTs or between different anti-oestrogen therapies. Combination with anti-inflammatory drugs did not improve the outcome. Toremifene was sometimes effective in cases resistant to tamoxifen. Response did not seem to be related to oestrogen receptor status.
CONCLUSIONS:
Despite potential inaccuracies in the methodology, the results of the review indicate that anti-oestrogen therapy produces some effect in about one half of patients with DTs. Its indication compared with other treatments is discussed
L’integrazione linguistica degli immigrati sul piano giuridico: diventare degli “Italiani col trattino”
No full textIl saggio, nell’indagare il rapporto tra lingua e diritto, pone in evidenza la politica linguistica “smarrita” per i cittadini immigrati da paesi non appartenenti all’Unione europea, nel sistema composito euro-nazional
Soviet Legacies in Minority Protection Thirty Years Down the Road
No full textanalysis of the recent evolution of the treatment of persons belonging to national minorities and overall of the changing attitude towards minorities in the post soviet spac
Il panorama linguistico di Rijeka (Fiume) e di Pula / Pola
Full text linkQuesto contributo vuole esaminare il panorama linguistico di due città croate: Rijeka (Fiume) e Pula/Pola. Tutti i segni fotografati in due strade con caratteristiche simili sono stati classificati in base alla lingua in cui sono scritti con l’obiettivo di indagare la vitalità d’uso delle diverse lingue che compongono il repertorio delle due città e di valutare se nel territorio bilingue della regione istro-quarnerina ci sia un’effettiva maggiore visibilità delle lingue minoritarie. Dopo una presentazione del quadro di riferimento teorico e dell’approccio metodologico della ricerca, si danno alcune informazioni sulle città oggetto dell’analisi e sul loro repertorio linguistico. Vengono poi presentati e discussi i risultati dell’indagine in relazione alla letteratura esplorata
Competing language ideologies and language policies in Ukraine and their impact on minorities
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Preface
Full text linkWhen the Soviet Union broke apart in 1991, the Russian Federation and the newly independent republics of the Baltics, the Caucasus and Central Asia engaged in redefining their national identity in a challenging regional and global context. The stances and policies towards the
minorities living in these countries became part of the striving towards national independence
and identity formation. Despite vastly different post-Soviet nation-building trajectories, the
development and implementation of state policies towards minorities had similar relevance and importance across the region. Thirty years after the end of the USSR what is the situation of minorities and minority issues in the countries that emerged from that multi-ethnic state?
How have the former republics – including Russia dealt with their minorities and minority affairs? To what protection and rights are minority communities entitled to?
Studies of the dissolution of the USSR and of nation-building in the independent post-Soviet
states have flourished over the past decades. However, despite the relevance of the theme, there is a dearth of specialist publications which address the many issues related to minority communities in the post-Soviet space. This volume attempts to fill this gap by providing a collection of essays covering some of the most relevant aspects of the contemporary status and situation of minorities in the area
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