1,720,975 research outputs found
Beating heart mitral valve repair with neochordae implantation: real-time monitoring of haemodynamic recovery
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Risk stratification of severe aortic stenosis according to new guidelines: Long term outcomes
Full text linkBackground: Current ESC and ACC/AHA guidelines for the management of valvular heart disease assign a class Ia indication for aortic valve replacement (AVR) only to patients with symptomatic severe aortic valve stenosis and asymptomatic patients with depressed left ventricular ejection fraction (LVEF <50%) or positive exercise test. We examined the long-term outcomes for patients undergoing AVR for aortic stenosis over a 11-year period at our institution compared to current international guidelines for AVR. Methods: Patients who had undergone isolated AVR for severe aortic valve stenosis between January 2001 and December 2012 were selected. The population was divided into subgroups based on preoperative LVEF (< or ≥50%) and on presence/absence of symptoms (NYHA =I or ≥II, respectively). Results: We identified 607 patients with a median follow-up (FU) time of 5.75 years (IQR 3.24–8.00 years). The presence of symptoms did not have a significant impact on cardiovascular mortality (P=0.201). Patients with LVEF <50% displayed a higher long-term cardiovascular mortality rate (P=0.015). Multivariate analysis showed that preserved LVEF was a protective factor for asymptomatic patients (P=0.021), while preoperative LVEF did not affect the mortality rate in symptomatic patients (HR 0.88; 95% CI, 0.54–1.44). Correspondingly, asymptomatic patients with reduced LVEF were found to be at a higher risk of long-term mortality compared to the other groups (P=0.011). The only other independent risk factor for death was age (HR 6.46; 95% CI, 2.22–18.76). Conclusions: According to our data, current international class I indications for symptomatic patients ensure good long-term survival, while class I indications for asymptomatic patients with reduced LVEF are associated with poor long-term survival. Our results suggest that early surgery should also be considered also for asymptomatic patients with preserved LVEF, particularly in cases of very low operative risk. © Journal of Thoracic Disease. All rights reserved
First-in-Human of Catheter-Delivered Annuloplasty Ring to Treat Functional Mitral Regurgitation
Full text linkTransapical off-pump mitral valve repair with Neochord Implantation (TOP-MINI): step-by-step guide
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First-in-Human of Catheter-Delivered Annuloplasty Ring to Treat Functional Mitral Regurgitation
No full textWe present images of a first-in-human case of Implantation of the Amend transcatheter mitral valve repair system (ValCare Medical, Herzliya, Israel) to treat functional mitral incompetence under a compassionate use approval
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Transapical off-pump mitral valve repair with Neochord implantation: Early clinical results
No full textTransapical off-pump mitral valve repair with Neochord implantation: Early clinical results
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