1,720,967 research outputs found
Lasmiditan: an additional therapeutic option for the acute treatment of migraine
No full textIntroduction: Migraine is currently listed as the second cause of ‘years lived with disability’ and the sixth cause of global disability. Despite the burden associated to the disease, availability of specific drugs is still limited. Areas covered: The authors have evaluated lasmiditan, the first ‘ditan’ approved by the Food and Drugs Administration in 2019, from a global perspective: basic chemistry, pharmacodynamic and pharmacokinetic profiles, efficacy in migraine as a 5-HT1F receptor selective agonist, tolerability and clinical safety, and impact on migraine-related disability. Our evaluation considered original papers and review articles published from 2010 to 2020. Expert opinion: Available data point to the efficacy of lasmiditan in reducing migraine pain and the most bothersome symptoms within 2 hours from oral administration. Moreover, lasmiditan has a positive effect on migraine-related disability. Its side effects mostly reflect an involvement of the central nervous system or the vestibular system, while cardiovascular side effects are rare and mild. Lasmiditan can be safely prescribed in patients who have failed non-steroid anti-inflammatory drugs or triptans or with cardiovascular risk factors. Caution is advised in frequent users, due to lack of reliable data on its abuse potential. Further data are necessary to determine the usability of lasmiditan in particular populations, e.g. children and adolescents, pregnancy
Effects of N fertilizers and rates on yield, safety and nutrients in processing spinach genotypes
No full textTwo field experiments were carried out at the Experimental Field, Department of Food Science (TE, Italy) in 2004 and 2005 to evaluate the
effects of genotypes, different N forms and N rates on yield, safety and nutritional features of processing spinach. Experiment 1, as treatments,
included spinach genotypes and N forms (CO(NH2)2; Agricote; NH4NO3); experiment 2 included three N forms (Ca(NO3)2; (NH4)2SO4; NH4NO3)
applied at rates of 0, 75, 150, 200 kg N ha1. This research work confirmed differences among spinach genotypes in terms of efficiency in N use
and oxalate and nitrate accumulation. Spinach accumulated much more nitrate in petioles and much more oxalate in blades indicating that nitrate
and oxalate might play a counterrole to each other. Fertilizers containing N under forms not readily available to the crop, i.e. Agricote, CO(NH2)2
and (NH4)2SO4, increased nitrate and oxalate accumulations less than fast N-release fertilizers, but their effect on yield was limited. Highest yield
with contents of nitrate and oxalate lower than the limits imposed to avoid health problems, were achieved with Ca(NO3)2, at rates of 130 and
150 kg N ha1 NH4NO3.
A good accumulation in some important macronutrients for the human diet such as Ca, K and P were allowed by application of Ca(NO3)2, at
rates of 130 and 150 kg N ha1 NH4NO3. The glucose, fructose, sucrose as well as Mg accumulation were not alterable in spinach with nitrogen
fertilization or with genotype choice
Effects of different N fertilizers and rates on yield and quality of different processing spinach genotypes
No full textInfluenza della fertilizzazione fogliare con magnesio sulla produzione e caratteristiche qualitative di cultivar di fagiolino (Phaseolus vulgaris L.)
No full textRisposta di cultivar di fagiolino (Phaseolus vulgaris L.) alla fertilizzazione fogliare con magnesio
No full textVariabilità spaziale del suolo e risposta quanti-qualitativa del frumento duro (Triticum Durum Desf.)
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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