102,053 research outputs found
G. ARESTI ETA BITAN BANATZEN DEN ELKARRIZKETA
No full textJUAN SAN MARTIN. G. ARESTI ETA BITAN BANATZEN DEN ELKARRIZKET
Je li ateizam bitan za marksizam?
No full textKršćansko-marksistički dijalog bio je u najvećem poletu u drugoj polovici šezdesetih godina. Najpoznatije međunarodne susrete organiziralo je njemačko društvo »Paulus Gesellschaft«. Iako je tadašnji zanos popustio, dijalog nije iščezao. On je prešao granice starog kontinenta. O tome svjedoči treći broj američkog časopisa Journal of Ecumenical Studies iz 1985. g., koji izdaje
tromjesečno Temple University u Philadelphiji. Donosi, prvo, dva predavanja s konferencije održane u travnju 1983. blizu Chicaga pod naslovod »Izazov i potreba kršćansko-marksističkog dijaloga«, zatim slijedi članak Jure Kriste »Marksistička kritika religije i hrvatska katolička kultura«. Najveći dio časopisa posvećen je pitanju da li je ateizam bitan za marksizam. To je pitanje, kao uvodni članak za temu, obradio američki isusovac Arthur F. McGovern, profesor filozofije na sveučilištu u Detroitu. Odgovara 17 autora među kojima je 5 marksista: 4 jugoslavena i jedna amerikanka
Structural Studies of Prion Proteins and Prions
No full textPrion diseases are a group of fatal and incurable neurodegenerative disorders of mammals. They uniquely manifest as sporadic, genetic, and infectious maladies. The agent responsible for prion diseases is the prion. A prion is defined as a proteinaceous infectious particle, which is solely constituted by an alternately folded form of the prion protein (PrP) (Prusiner 1982).
In diseased animals and humans, PrP exists in two forms, the physiological, cel- lular form of PrP, PrPC, and the pathological prion form denoted as PrPSc. The mech- anism whereby nascent PrPSc is generated is currently unknown. Structural studies of either isoform are of great importance for understanding the biology of prion diseases since they may clarify the molecular mechanisms responsible for these pathologies. In this chapter, we present an overview of the studies into PrPC as well as structures of prions
Acne Keloidalis Nuchae and the Metabolic Syndrome : a Population-Based Study
No full textBackground: The association between acne keloidalis nuchae (AKN) and the metabolic syndrome (MS) has been reported anecdotally. However, it is yet to be investigated in the setting of controlled studies, leaving this topic inconclusive in the current literature. Objective: The aim was to estimate the association between AKN and the MS and its components, utilizing one of the largest cohorts of patients with AKN. Methods: A retrospective, population-based, cross-sectional study was performed between 2005 and 2018. We utilized the database of Clalit Health Services, the largest public healthcare provider organization in Israel. The current study encompassed data collected from general community clinics, primary care, and referral centers, as well as from ambulatory and hospital care. Results: A total of 2677 patients with AKN and 13,190 controls were included. The prevalence of the MS was greater in patients with AKN than in control subjects (16.1% vs. 6.6%, respectively; odds ratio [OR] 2.72; 95% confidence interval [CI] 2.40–3.08; P < 0.001). Obesity demonstrated the strongest association with AKN (OR 3.00; 95% CI 2.75–3.28), followed by type 2 diabetes mellitus (OR 2.47; 95% CI 2.20–2.77), hypertension (OR 1.82; 95% CI 1.63–2.05), and dyslipidemia (OR 1.60; 95% CI 1.46–1.75). Estimates were not altered significantly after controlling for putative confounding factors. Conclusions: A strong association was observed between AKN and the MS on the one hand, and with every one of its four components on the other. Physicians treating patients with AKN should be aware of this possible comorbidity. Patients with AKN should be carefully assessed for comorbid metabolic disorders
Dipeptidyl-peptidase IV inhibitor (DPP4i) confers increased odds of bullous pemphigoid even years after drug initiation
No full textThe timing pattern in which dipeptidyl-peptidase IV inhibitors (DPP4i) confer the risk of bullous pemphigoid (BP) is unknown. To investigate the odds of BP following exposure to DPP4i and to perform a duration-response analysis evaluating the risk of BP in relation to the duration of exposure to the culprit drug. A population-based nested case–control study was performed comparing diabetic patients with BP (n = 1458) with age-, sex- and ethnicity-matched diabetic control subjects (n = 6051) with respect to the prevalence of exposure to DPP4i. Adjusted odds ratios (ORs) were estimated by logistic regression. Overall exposure to DPP4i was associated with an 80% increase in the odds of subsequent BP (OR, 1.81; 95% CI, 1.46–2.08; P < 0.001). In an intraclass analysis, the odds of BP were increased in association with vildagliptin (OR, 3.40; 95% CI, 2.69–4.29; P < 0.001) and sitagliptin (OR, 1.56; 95% CI, 1.33–1.84; P < 0.001). In a duration-response analysis, the highest likelihood of BP was found 1–2 years after commencing the drug (OR, 2.66; 95% CI, 1.97–3.59; P < 0.001). The odds of BP were increased across all time periods and retained its statistical significance even ≥ 6 years after the drug initiation (OR, 1.44; 95% CI, 1.09–1.91; P = 0.011). Relative to other diabetic patients with BP, patients with DPP4i-associated BP were more likely to be admitted to inpatient dermatologic wards (OR, 1.66; 95% CI, 1.30–2.13; P < 0.001) and had higher mean(SD) numbers of outpatient dermatologist visits (14.7[14.8] vs. 12.3[13.2], respectively; P = 0.006). DPP4i should be suspected as a predisposing factor for BP even numerous years after the drug initiation
Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Quantification of the relationship between pyoderma gangrenosum and Crohn’s disease : a population-based case-control study
No full textBackground: Although Crohn’s disease (CD) is an established underlying disease in pyoderma gangrenosum (PG), studies comparing patients with PG and controls with respect to the presence of CD are lacking. Consequently, the relative risk imposed by CD for the development of PG is yet to be elucidated. Objective: The study aims to quantify the magnitude of the association between CD and subsequent development of PG, thus enabling to evaluate the risk of PG with CD. Methods: A matched case-control study was conducted in Israel comparing PG patients (N = 302) with age-, sex- and ethnicity-matched control subjects (N = 1497) regarding the presence of CD. Logistic regression model was used for multivariate analysis. Results: The prevalence of CD was higher in patients with PG than in control subjects (7.0% vs. 0.3%, respectively; p <.001). There was a 28-fold increase in the odds of PG with CD (OR, 28.08; 95% CI, 9.56–82.41). This association was robust to a sensitivity analysis excluding CD cases diagnosed up to 3 years prior to PG (OR, 30.30; 95% CI, 8.82–104.09), and to a multivariate analysis adjusting for confounding factors (OR, 21.57; 95% CI, 7.20–64.58). The median latency between the diagnosis of CD and the development of PG was 8.08 years. Patients with both PG and CD were younger and had a higher prevalence of smoking when compared to other patients with PG. Conclusions: CD increases the odds of having PG by 28-folds. Patients with CD should be advised to avoid additional precipitating factors of PG like pathergy and smoking
Recommended from our members
3346: Samuel G. Freedman, author, 2013
No full textPhotograph of author Samuel G. Freedman, at NT Daily Slash meeting in the Mayborn School of Journalism at UNT
- …
