1,720,957 research outputs found
Understanding the molecular basis and pathogenesis of hereditary optic neuropathies: towards improved diagnosis and management
No full textHereditary optic neuropathies result from defects in the human genome, both nuclear and mitochondrial. The two main and most recognised phenotypes are dominant optic atrophy and Leber hereditary optic neuropathy.
Advances in modern molecular diagnosis have expanded our knowledge of genotypes and phenotypes of inherited disorders that affect the optic nerve, either alone or in combination, with various forms of neurological and systemic
degeneration. A unifying feature in the pathophysiology of these disorders appears to involve mitochondrial dysfunction, suggesting that the retinal ganglion cells and their axons are especially susceptible to perturbations in mitochondrial homoeostasis. As we better understand the pathogenesis behind these genetic diseases, aetiologically targeted therapies are emerging and entering into clinical trials, including treatments aimed at halting the cascade of neurodegeneration, replacing or editing the defective genes or their protein products, and potentially regenerating damaged optic nerves, as well as preventing generational disease transmission
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Neuro-ophthalmology illustrated/ Valérie Biousse, Nancy J. Newman.
No full textIncludes index."Neuro-ophthalmology is an "overlap" specialty, encompassing all disorders that affect the parts of the central nervous system related to vision. Neuro-Ophthalmology Illustrated, Third Edition by world-renowned neuro-ophthalmologists and professors Valérie Biousse and Nancy J. Newman expands on the widely acclaimed prior editions, lauded with awards by the Association of American Publishers and the British Medical Association. The updated text reflects diagnostic advances such as optical coherence tomography and features new high-quality images and videos. The text starts with neuro-ophthalmic and funduscopic examinations, visual fields, commonly used ancillary testing methods, and an overview of visual loss. Subsequent chapters detail a wide array of conditions including retinal vascular diseases, optic neuropathies, disc edema, disorders of higher cortical function, abnormal visual perceptions, diplopia, orbital syndromes, cavernous sinus and orbital vascular disorders, nystagmus/other ocular oscillations, and disorders of the eyelid. Final chapters are dedicated to nonorganic neuro-ophthalmic symptoms and signs, diagnosis of headache and facial pain, neurologic and systemic disorders that commonly have neuro-ophthalmologic manifestations, and an approach to management of the visually impaired patient. Key Highlights Concise text coupled with more than 600high-quality images enhances understanding of complex concepts Easily accessible within pertinent sections, 69 video clips cover a wide spectrum of topics such as examination techniques, normal eye movements, eye movement disorders, and pupil findings Clinical pearls, flow charts, boxes, tables, and a highly detailed index at the end of the text improve retention and assimilation of knowledge This book is essential reading for students, ophthalmology, neurology, and neurosurgery residents, as well as seasoned clinicians in these specialties. At once authoritative and easy to read, this resource provides readers with all the tools they need to diagnose and manage neuro-ophthalmologic disorders"--The Neuro-Ophthalmic Examination -- Funduscopic Examination -- Visual Fields -- Ancillary Testing Commonly Used in Neuro-Ophthalmology -- Visual Loss : An Overview -- Transient Visual Loss -- Retinal Vascular Diseases -- Optic Neuropathies -- Disc Edema -- Disorders of Higher Cortical Function -- Abnormal Visual Perceptions : Hallucinations and Illusions -- The Pupil -- Diplopia -- Orbital Syndrome -- Cavernous Sinus and Orbital Vascular Disorders -- Nystagmus and Other Ocular Oscillations -- Disorders of the Eyelid -- Nonorganic Neuro-Ophthalmic Symptoms and Signs -- Diagnosis of Headache and Facial Pain -- Disorders Commonly Encountered in Neuro-Ophthalmology -- The Visually Impaired Patient1 online resource (xvi, 674 pages)
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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