1,721,004 research outputs found
Stochastic equilibrium traffic assignment with value-of-time distributed among users
No full textIn this paper, existing fixed-point models for stochastic equilibrium traffic assignment to transportation networks are extended to deal with the value of time distributed among users. This problem is relevant when transporation demand management measures affecting travelling monetary costs are to be evaluated. Analysis of existence and uniqueness of solutions is carried out, leading to mild assumptions about link cost-flow functions, path choice model, and value-of-time distribution. Some quite simple solution algorithms are also specified and their convergence analysed. Results of some applications are also reporte
Requirements analisys of a bike sharing system based on ITS applications
No full textPubblicato su CD con codice paper 321
Facing Equity and Social Inclusion in Transportation Planning: New Paradigms of Sustainability
No full textAnalisi dei requisiti e delle criticità di un sistema di Bike-Sharing per una mobilità sostenibile
No full textObstructing Left-Sided Colonic Cancer: Is Endoscopic Stenting a Bridge to Surgery or a Bridge to Nowhere?
No full textFor the 8–29% colorectal cancers that initially manifest with obstruction, emergency surgery (ES) was traditionally considered the only available therapy, despite high morbidity and mortality rates and the need for colostomy creation. More recently, malignant obstruction of the left colon can be temporized by endoscopic placement of a self-expanding metallic stent (SEMS), used as bridge to surgery (BTS), facilitating a laparoscopic approach and increasing the likelihood that a primary anastomosis instead of stoma would be used. Despite these attractive outcomes, the superiority of the BTS approach is not clearly established. Few authors have stressed the potential cancer risk associated with perforations that may occur during endoscopic stent placement, facilitating neoplastic spread and negatively impacting prognosis. For this reason, the current literature focuses on long-term oncologic outcomes such as disease-free survival, overall survival and recurrence rate that do seem not to differ between the ES and BTS approaches. This lack of consensus has spawned differing and sometimes discordant guidelines worldwide. In conclusion, 20 years after the first description of a colonic stent as BTS, the debate is still open, but the growing number of articles about the use of SEMS as a BTS signifies a great interest in the topic. We hope that these data will finally converge on a single set of recommendations supporting a management strategy with well-demonstrated superiority
Proteogenomic biomarkers in colorectal cancers: clinical applications
Full text linkIntroduction: Colorectal cancer (CRC) is one of the leading cancers in terms of incidence and mortality, rate requiring a multidisciplinary approach. The discovery of specific CRC biomarkers has caused a paradigm shift in its clinical management. Areas covered: The aim is to illustrate the possible clinical applications of CRC biomarkers through an updated literature review (from 2015 to 2020) based on the PubMed database. A relationship between cancer localization and genetic profile has been identified. Nowadays, the tumor markers are largely used to select patients that could really benefit from a specific type of adjuvant therapy, in order to optimize treatment programs, especially in metastatic patients. This review highlights both CRC biomarkers’ advantages and critical issues. Expert opinion: New biomarker discoveries allow to set noninvasive tests that could increase patient’s compliance with therapy. They also permit a cost-effective early diagnosis, as well as patient-tailored treatments, improving the overall survival. The CRC biomarkers could also have a prognostic value, and usually, they are included in follow-up programs. However, despite the continuous progression of new technologies, their clinical validation is still debated. In this context, additional clinical studies are still necessary to identify, among potential markers, the most effective ones
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
A dynamic IS–LM model with two time delays in the public sector.
No full textSome recent contributions to Economic Dynamics have shown an increasing interest on the
impact that fiscal policy lags may have on the income adjustment processes. Lags dealing
with fiscal policy come from delays either in the government expenditure or in the tax revenues.
These two lags yield jointly their macroeconomic effects. They are such that to make
traditional fiscal policy rules ineffectual to control, and stabilize the GDP dynamics. Here
we study a dynamic IS–LM model where the public expenditure and the tax revenues have
a delayed functional form. We show that the equilibrium of the system may lose or gain its
local stability depending either on the length of the lags or on their particular combinations.
When instability arises, very complicated dynamics may characterize the national
income time path
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