186,289 research outputs found
Título: Summa theologica
No full textNotas a pié de página a dos columnasTexto fileteado a dos columnasMarca tipográfica en la portadaNotas a pé páx. a dúas colTexto fileteado a dúas colMarca tip. en portContiene: Tomus primus, pars 1ª (768 p.) -- Tomus secundus, pars 1ª-2ª (732 p.) -- Tomus tertius, pars 2ª-2ªa Qu.I.usque ad Qu.CXXIII -- Tomus quartus, pars 2ª-2ae a Qu. CXXIV ad finem, pars 3ª a Qu. I ad LXII (819 p.) -- Tomus quintus, pars 3ª. a Qu. LXIII ad finem et supplementum 3ae partis (824 p) -- Tomus sextus. Indices et lexicon (438, 41* p.)Contén: Tomus primus, pars 1ª (768 p.) -- Tomus secundus, pars 1ª-2ª (732 p.) -- Tomus tertius, pars 2ª-2ªa Qu.I.usque ad Qu.CXXIII -- Tomus quartus, pars 2ª-2ae a Qu. CXXIV ad finem, pars 3ª a Qu. I ad LXII (819 p.) -- Tomus quintus, pars 3ª. a Qu. LXIII ad finem et supplementum 3ae partis (824 p) -- Tomus sextus. Indices et lexicon (438, 41* p.
[Summa Theologica]
No full textSignaturizadoMarca tipográfica na portadaTexto a dúas columnasContén: t. IV: Pars 2ª 2\pae\s a Qu. CXXIV ad finem, pars 3ª a Qu. I ad LXII, (819 p.) -- t. V: Pars 3ª a Qu. LXIII ad finem et supplementum 3\pae\s partis, (824 p.) -- t. VI (438, 41 p.
Oligophrenin-1 regulates synaptic activity dependent shuttling between synapses and nucleus of Rev-erbAalpha
No full textOligophrenin-1 (OPHN1) is a synaptic RhoGTPase-activating protein involved in X-linked mental
retardation that regulates dendritic spines shape and outgrowth of axons in brain (Govek et al., 2004).
By using the C-terminal fragment of Oligophrenin 1 as bait in a two-hybrid screening of a human fetal
brain cDNA library we identified as an interactor, NR1D1 (Rev-erbAalpha). Rev-erbAalpha is an
orphan nuclear receptor that constitutively suppresses gene transcription and regulates the circadian
clock in the CNS (Preitner et al. 2002). We confirmed the interaction in vitro and in vivo by
co-immunoprecipitation and GST-pull down.
In COS-7 cells we observed that overexpressed Oligophrenin-1 is able to recruit Rev-erbAalpha
(normally localized in the nucleus) to the cytoplasm. Furthermore, overexpression Oligophrenin-1
induces an accumulation of endogenous Rev-erbAalpha in dendritic spines in hippocampal neurons.
The Oligophrenin-1deltaC (deleted of C-terminus), a mutant that mimics the mutation present in the
XLMR patients, wasn’t able to induce this effect in COS7 and in hippocampal neurons. In HEK cells
we observed that Oligophrenin-1 protects Rev-erbAalpha from degradation by GSK3beta We also
have found that RNAi knockdown of Oligophrenin-1 inhibited the translocation of Rev-erbAalpha into
the dendritic spines. More remarkable, synaptic activity mediated by AMPA receptors induces
translocation of Rev-erbAalpha to the dendritic spines. RNAi experiments showed that Oligophrenin-1
is required for the translocation of Rev-erbAalpha in spines induced by synaptic activity. Moreover we
observed an alteration of Rev-erbAalpha expression in Oligophrenin-1 KO mouse: there is a reduction
of Rev-erbAalpha in hippocampus.
Our results demonstrate for the first time the interaction between an orphan receptor (Rev-erbAalpha)
and a synaptic protein (Oligophrenin-1). This interaction regulates the localization of Rev-erbAalpha
between synapse and nucleus induced by synaptic activation
Summary of the steps from the selection of slices to angle measurements.
No full text(A) The 3D model is segmented in several plane sections according to the methodology presented above. (B) After selecting the slices according to the anatomical description by Sakoma et al. [22] and in which a portion of the ILSS is “stamped”, the biomechanical model developed by Billuart et al. [20] (C) is used to carry out the angle measurements (D).</p
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Pharmacological rescue of adult hippocampal neurogenesis in a mouse model of X-linked intellectual disability
No full textOligophrenin-1 (OPHN1) is a Rho GTPase activating protein whose mutations cause X-linked intellectual disability (XLID). How loss of function of Ophnl affects neuronal development is only partly understood. Here we have exploited adult hippocampal neurogenesis to dissect the steps of neuronal differentiation that are affected by Ophn1 deletion. We found that mice lacking Ophnl display a reduction in the number of newborn neurons in the dentate gyrus. A significant fraction of the Ophn1-deficient newly generated neurons failed to extend an axon towards CM, and showed an altered density of dendritic protrusions. Since Ophnl-deficient mice display overactivation of Rho-associated protein kinase (ROCK) and protein kinase A (PICA) signaling, we administered a clinically approved ROCK/PICA inhibitor (fasudil) to correct the neurogenesis defects. While administration of fasudil was not effective in rescuing axon formation, the same treatment completely restored spine density to control levels, and enhanced the long-term survival of adult-born neurons in mice lacking Ophn1. These results identify specific neurodevelopmental steps that are impacted by Ophn1 deletion, and indicate that they may be at least partially corrected by pharmacological treatment. (C) 2017 The Authors. Published by Elsevier Inc
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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