1,721,023 research outputs found

    Kimura Disease's: A Case Report

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    Bilir, Cemil/0000-0002-1372-4791WOS: 000272760300009Kimura is a chronic inflammatory disease at oral mucosa which presents as large subcutaneous nodules or masses on the head or neck of adulthood males The lesions characteristics are eosinophilia in lymphocytic infiltration, fibrosis and diffuse vascularity. Eosinophilia and elevated blood IgE can be present. A 62 years old female with inguinal mass and itching was presented (Turkderm 2009, 43 171-3

    Oral ulcers caused by Alendronate use

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    Bilir, Cemil/0000-0002-1372-4791WOS: 000258755900009Bisphosphonates are the drugs which modulate bone turnover and reduce bone reabsorbsion. Hence, they are used in postmenopausal osteoporosis, multiple myeloma or osteolisis associated with malign cancer. The rare complications are appearing more often now because of their wide use in treatments. Most important possible adverse effects belong to gastrointestinal systems; esophagitis, gastric ulcers, dyspepsia, heartburn and rarely oral ulcers, osteonecrosis on jaws and esophagial stricturs are illustrated

    Isolated Renal Vein Thrombosis Associated With MTHFR-1298 and PAI-1 4G Gene Mutations

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    Bilir, Cemil/0000-0002-1372-4791WOS: 000284901300019PubMed: 19825918Isolated renal vein thrombosis is very rare without the presence of nephrotic syndrome. It is more common in the newborns and infants. Whereas major risk factors in adults are the procoagulant states such as protein C or S deficiency, factor V Leiden mutation, primary or secondary antiphospholipid syndrome, severe hypothyroidism, and trauma. Here, we report a case of isolated renal vein thrombosis associated with MTHFR-1298 and PAI-1 4G gene mutations. It should be noted that the presence of MTHFR-1298 and PAI-1 4G gene mutations together might be one of the examples of genetic mutation combinations that increase the likelihood of a thrombotic event

    Prognostic Value of Volumetric Parameters of PET-CT With Stage IIIB-IV Non-Small Cell Lung Cancer

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    Annual Congress of the European-Association-of-Nuclear-Medicine -- OCT 15-19, 2016 -- Barcelona, SPAIN...European Assoc Nucl Me

    Relationship between 18F-FDG uptake on PET/CT and expression of Ki-67 and p53 proteins in patient with lung cancer: a clinocopathologic study

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    Bilir, Cemil/0000-0002-1372-4791Introduction Lung cancer is the 2nd most common malignancy in both of men and women. It is also the most common cause of cancer related deaths.1 Nearly 85% of lung cancers were diagnosed as large cell carcinoma, adenocarcinoma (AC), and squamous cell carcinoma (SCC) classified as non-small cell lung carcinoma (NSCLC). One third of the newly diagnosed NSLC patients were diagnosed at advanced stages (Stage IIIA or IIIB), and they are not suitable for surgical treatment. The 5-year survival rate of these patients is 16%.2,

    Aplastic crisis due to Parvovirus B19 in an adult hereditary spherocytosis patient: Case report

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    Bilir, Cemil/0000-0002-1372-4791; Alcelik, Aytekin/0000-0002-3156-1076WOS: 000259856300026Parvovirus B19 may cause transient aplastic crises in hereditary hemolytic anemia patients. A 29-year-old male presenting with fatigue, fever and diffuse joint and Muscle pain was admitted to the internal medicine service. He later developed leukopenia, thrombocytopenia and marked anemia with 0.8% reticulocytes. The bone marrow biopsy proved normocellular with increased proetrithroblasts and decreased mature erythroblasts. On day 6 of admission, his complete blood count (CBC) started to return to normal and the aplastic crisis was attributed to parvovirus B19 infection. Anti-IgM B19 antibody positivity supported the diagnosis and the clinical picture. This is the first reported Parvovirus B19-induced aplastic crisis in an adult hereditary spherocytosis patient in Turkey

    Increased Serum Asymmetric Dimethylarginine Levels in Primary Dysmenorrhea

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    Bilir, Cemil/0000-0002-1372-4791WOS: 000273553000002PubMed: 19996604Background: Primary dysmenorrhea is a common disorder among young women, and uterine ischemia plays an important role in pelvic pain. Asymmetric dimethylarginine (ADMA) is accepted as a strong marker of endothelial dysfunction. Objective: To investigate the role of ADMA in primary dysmenorrhea. Methods: Thirty-three patients with primary dysmenorrhea and 29 healthy controls were evaluated in a hospital outpatient clinic-based study. Secondary causes of dysmenorrhea had been ruled out in each patient. LDL cholesterol, triglycerides measured and body mass index were also calculated. Blood samples for determination of ADMA concentration were drawn on the 3rd day of menses in each woman. Groups were compared for statistically significant difference by Mann-Whitney U test. Results: Groups did not differ in age or hormone levels. ADMA level was higher in women with dysmenorrhea compared to healthy controls (Mann-Whitney U test, Z = -2.24, p = 0.025). ADMA levels showed positive correlation with age and erythrocyte sedimentation rate in the first group (Spearman's rho = 0.360, p = 0.040, and r = 0.379, p = 0.029, respectively). Although erythrocyte sedimentation rate and C-reactive protein (CRP) were positively correlated, no significant correlations were found between high-sensitivity CRP and ADMA level in the first group (Spearman's rho = 0.048, p = 0.749). Conclusion: ADMA concentrations are elevated in primary dysmenorrhea compared to healthy controls. This suggests that endothelial dysfunction plays a role in primary dysmenorrhea. Copyright (C) 2009 S. Karger AG, Base
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