36 research outputs found

    Music, Time, Memory : an Interpretation of Musical Experience according to the “Evential Hermeneutics”

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    Dans cette thèse, nous nous attachons à décrire et à interpréter, en tant que telle, l’expérience de la musique qui survient et apparaît à chacun de nous, expérience musicale qui commence par la rencontre, c’est-à-dire par l’événement où se rencontrent la musique et l’homme. Pour ce faire, nous reposons sur l’ « herméneutique événementiale » de Claude Romano en laquelle l’événement et l’être humain sont étroitement liés. Nous essayons de considérer d’abord, surtout, deux choses : les difficultés et limites de penser l’expérience musicale à partir du sujet ou de la subjectivité chez Augustin et Husserl (plus particulièrement dans la phénoménologie transcendantale de ce dernier), d’une part, et de l’autre, la possibilité d’approcher l’expérience de la musique à partir de l’ipséité. En suivant non seulement la phénoménologie herméneutique susmentionnée chez Claude Romano, mais aussi le « monde de la vie » et l’ « être-au-monde » renouvelés de manière réaliste par lui, nous tentons ensuite de décrire les phénomènes qui se montrent à travers chaque événement de la musique de Frédéric Chopin dont je (auteur de cette thèse) fais l’expérience en mettant en jeu moi-même en tant que corps (phénoménal). Il ne s’agit ici, pour nous, ni d’un phénomène purement objectif, ni d’un phénomène de part en part subjectif, mais de phénomènes relationnels. Ce que nous nous efforçons de montrer au travers de ce travail tout entier, ce n’est pas l’expérience de la musique comme expérience des phénomènes de conscience, mais celle comme expérience du monde dans sa relation avec moi-même en mon ipséité.In this thesis, we set out to describe and to interpret, as such, the experience of music that occurs and appears to each of us, the musical experience that begins with the encounter, that is, with the event when music and man meet. To do so, we rely on Claude Romano’s “evential hermeneutics” (translation by Shane Mackinlay) in which the event and the human being are closely linked. We try to consider first, especially, two things: the difficulties and limits of thinking the musical experience on the basis of the subject or subjectivity in Augustine and Husserl (more particularly in the transcendental phenomenology of the latter), on the one hand, and on the other, the possibility of approaching the musical experience from the ipseity. By following not only the aforementioned hermeneutical phenomenology in Claude Romano, but also the “life-world” and the “being-in-the-world” which are renewed in a realist way by him, we then attempt to describe the phenomena that show themselves through each event of Fryderyk Chopin’s music which I (author of this thesis) experience by putting at stake myself as a (phenomenal) body. The matter here, for us, is neither a purely objective phenomenon, nor a totally subjective phenomenon, but relational phenomena. That we strive to show through the whole of this work, it is not the experience of music as an experience of the phenomena of consciousness, but the one as an experience of the world in its relationship with myself in my ipseity

    Enóloga Asistente durante la Temporada de Vendimia 2023, Viña Biodinámica Koyle, San Fernando, Chile.

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    Wine is the beverage obtained by the alcoholic fermentation of grape (Vitis vinifera) must. During the harvest season, vineyards hire external personnel are hired to support the winemaking team. These personnel carry out various activities in the winery, including supervision of workers, preparation of work orders, coordination, and organization of the crushing yard and, most importantly, monitoring of fermentation. In the southern hemisphere, the grape harvest begins, in early January and end in May, although dates vary depending on the country and the climatic conditions of each region. In Chile, the Koyle winery is located in the Colchagua Valley, where external personnel were hired to support the winemaking and field team beginning at the end of January 2023. During the month of February, samples were collected each week from the vineyard's 59 plots to determine the optimal timing of the harvest. Koyle is a biodynamic project that seeks to manage the soil and natural resources without using synthetic fertilizers or pesticides, maintaining a balance between the microorganisms and animals that inhabit the vineyard in order to express the terroir to its maximum potential in the wine. On Tuesday, March 8, 2023, the harvest of the different red varieties began, culminating with 1,200,000 kg of grapes. The rules established by the Demeter certification for wine production were rigorously followed, from the reception of the grapes through the whole winemaking process. The main problem during the harvest is that the external support personnel hired do not have any previous experience or studies related to viticulture, so assistant winemakers are also hired to support the chief winemaker during this season to supervise and train the staff. It is a job that requires attention to detail, cleanliness and responsibility throughout the winemaking process. During this harvest season, the author of this work directed interns and operators during the entire winemaking process, teaching them to work as a team and in an orderly manner to avoid accidents, as well as to maintain the cleanliness and responsibility of each worker in their assigned activities. Working in another country gave the author an advantage in the employment market, since Chile as a nation is widely recognized for its winemaking trajectory

    Hypotensive and antihypertensive effects of Pterocarpus santalinoides stem barks aqueous extract on oxidized palm oil and sucrose-induced hypertensive rats

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    Objective: This study was aimed to evaluate the hypotensive and antihypertensive effects of the stem barks aqueous extract of Pterocarpus santalinoides (AEPS) on oxidized palm oil and sucrose-induced hypertensive rats. Methods: Hypotensive effects of AEPS, were evaluated in Wistar rats by intravenous injection of the extract (5, 10, 20 and 30 mg/kg). The arterial pressure and heart rate were directly recorded. The action mechanism through which the extract exhibits hypotensive effect was performed. Antihypertensive effects of AEPS were evaluated by administrating the enriched diet in oxidized palm oil and sucrose (DOS) concomitantly with AEPS (50, 100 and 200 mg/kg) during 8 weeks. Results: AEPS provoked a significant immediate decrease of mean blood pressure and heart rate. Atropine and reserpine, reduced significantly (p < 0.01) the hypotensive effect of P. santalinoides. The enriched diet in oxidized palm oil and sucrose significantly increased the blood pressure and heart rate (p < 0.001) by the increase (p < 0.001) of total cholesterol, triglycerides, LDL-cholesterol and a decrease of HDL-cholesterol. DOS also increased the liver (AST and ALT) and kidney (urea, creatinine) marker levels. The activity of SOD, catalase and MDA levels were significantly increased. The AEPS prevented the increase (p < 0.001) in blood pressure and heart rate. The Lipid profile, liver and kidney functions and oxidative stress markers were also improved. Conclusion: Pterocarpus santalinoides exhibits a hypotensive activity through muscarinic cholinergic receptors and sympatic central nervous system. It also prevents DOS-induced hypertension by attenuating hyperlipidemia, oxidative stress, liver and kidney damages initiated by DOS

    Les modalités de réécriture chez Madeleine Ferron /

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    My thesis studies rewriting in the works of Madeleine Ferron. I analyze passages Ferron took from her own writings and rewrote in later texts. Between 1960 and 1995, Ferron produced 114 texts; they include tales, short stories, articles, novels, ethnographic studies and biographies. The author rewrote twenty-two passages and four complete texts. My study describes and analyzes the functions of the rewriting process in these texts: it explores, among others, literary devices, thematic structures and the manner in which the rewritings determine editorial strategies. Rewriting is at the core of the Ferronian esthetic and is here characterized by the transposition of genres, and corresponding processes of fictionalization or defictionalization. I identify three stages in Madeleine Ferron's writing career: the early years (1960--1970), when Jacques Ferron (her brother, a well-known writer) rewrote Madeleine's texts, the period during which her major works were produced (1971--1989); and 1990 to 1995, the period that saw the publication of her most "personal" texts; these chronological divisions correspond to the three main chapters of this thesis

    Effect of the aqueous extract of Gymnema sylvestre on some metabolic disturbances in a model of insulin resistant induced by dexamethasone and high sucrose diet on rat

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    Introduction: Insulin resistance (IR) is when cells don’t respond well to insulin and can’t easily take up glucose from the blood. Such situation may lead to chronic hyperglycemia and even diabetes. Gymnema sylvestre aqueous extract is known in traditional Chinese medicine for its hypoglycemic activity. Some studies suggest that gymnemic acids, triterpene glucosides, and saponins may be responsible for this plant's impact on blood glucose regulation. This study aimed to evaluate the effects of Gymnema sylvestre aqueous extract (AEGS) on rat model of IR. Methods: IR was induced in male Wistar rats aged between 5 and 6 weeks by a high sucrose diet during 20 weeks then an intraperitoneal injection of dexamethasone (4mg/kg) once daily during 7 consecutive days. IR rats were divided into 5 groups of 5 animals each and received orally the different treatments as follows: a negative IR control group (NC-IR) received distilled water (10mL/kg), a positive IR control group (PC-IR) received metformin (200mg/kg), three experimental groups received AEGS (50, 100 and 200 mg/kg respectively). The different treatments were administered for 14 days. At the end of treatment, animals were sacrificed after urine collection; serum and homogenates from liver kidney and pancreas were prepared for biochemical analysis and histology. Results: Compared to NC-IR, AEGS at all doses tested significantly reduced IR. It is the same for glucose, creatinine, direct bilirubin, serum transaminase total proteins and uric acid. The histopathological study revealed that AEGS restored tissues injuries induced by dexamethasone combined with high-sucrose diet, thus justifying its empirical use. Discussion: The results obtained in this study suggest that AEGS have hypoglycemic, hepatoprotective and nephroprotective properties

    Bidens pilosa Ethylene acetate extract can protect against L-NAME-induced hypertension on rats

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    Abstract Background Essential hypertension is mainly caused by endothelial dysfunction which results from nitric oxide (NO) deficiency. The present study was design to evaluate the protective effect of Bidens pilosa ethylene acetate extract (Bp) on L-NAME induced hypertension and oxidative stress in rats. Methods Male Wistar rats were used to induce hypertension by the administration of L-NAME (a non-pecific nitric oxide inhibitor) (50 mg/kg/day). The others groups were receiving concomitantly L-NAME plus Bp extract (75 and 150 mg/kg/day) or losartan (25 mg/kg/day). All the treatments were given orally for 4 weeks. At the end of the treatment, the hemodynamic parameters were recorded using the direct cannulation method. The effects of the extract on lipid profile, kidney and liver functions as well as oxidative stress markers were evaluated by colorimetric method. Results were expressed as the mean ± SEM. The difference between the groups was compared using one-way analysis of variance (ANOVA) followed by the Duncan’s post hoc test. Results Animals receiving L-NAME presented high blood pressure, normal heart rate and lipid profile as well as NO depletion, liver and kidney injuries and oxidative stress. The concomitant treatment with L-NAME and Bp or losartan succeeded to prevent the raised of blood pressure and all the other injuries without affecting the heart rate. Conclusion These results confirm the antihypertensive effects of Bidens pilosa and highlight its protective properties in L-NAME model of hypertension in rat, probably due to the presence of Quercetin 3,3 ‘-dimethyl ether 7–0-β-D-glucopyranoside

    Ethanolic and aqueous extracts of Lantana camara show antiepileptic and anxiolytic effects by inhibiting the ferroptosis pathway in kainate-treated mice

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    In Cameroon, epilepsy is one of the most common neurological diseases. Available anti-epileptic medication, on the other hand, have been associated with pharmacological toxicity and emotional impairment. The identification of a more efficient replacement is critical. Recent research reveals that ferroptosis contributes to the pathophysiology of epilepsy and related anxiety disorders. Lantana camara is a plant with a high neuropharmacological potential, but its mechanisms of action have yet to be understood. The purpose of this study was to determine the effect of ethanolic and aqueous extracts of Lantana camara on the kainate model of epilepsy in mice. The focus was on these extracts' capacity to suppress ferroptosis. Mice were injected with kainate (12 mg/kg, i.p.) to induce epilepsy. After status epilepticus, animals were left for 19 days, which correspond to an epileptogenic period. After the appearance of spontaneous recurrent seizures, mice were treated with distilled water (10 ml/kg, p.o.), levetiracetam (80 mg/kg, p.o.), sodium valproate (300 mg/kg, p.o.), ethanolic extract of L. camara (230, 460, 920 mg/kg, p.o.), or an aqueous extract of L. camara (460 mg/kg p.o.). These treatments lasted for 14 days. During this period, the number and duration of seizures were recorded. The mice were then subjected to elevated zero-maze and open field tests to assess anxiety-like behavior. At the end, mice were sacrificed and hippocampus, amygdala, and striatum were dissected out for biochemical and histological analyses. The extracts alleviated seizure- and anxiety-like behavior in KA-treated mice. Decreased iron levels, reflected by a decrease in ferritin levels and a increase in transferrin levels, were observed in the hippocampus, striatum and amygdala of the extract-treated group compared to the KA-treated group. In addition, increase in GABA and GSH levels, and a decrease in MDA levels were observed in these groups. Hematoxylin-eosin staining revealed less pronounced neuronal degeneration and a more sustained architecture in the brain region of extract-treated mice. These findings indicated that ethanolic and aqueous extracts of L. camara effectively attenuate seizures and anxiety disorders. Probable mechanisms of action include GABAergic, iron, GSH, and MDA modulations

    Reviews of recent publications

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    Alonso, Carlos J. The Burden of Modernity: The Rhetoric of Cultural Discourse in Spanish America Reviewed by Melvin S. Arrington, Jr. Kolocotroni, Vassiliki, Jane Goldman, and Olga Taxidou, eds, Modernism: An Anthology of Sources and Documents Reviewed by Gerd Bayer Motte, Warren. Small Worlds: Minimalism in Contemporary French Literature Reviewed by William Cloonan Melton, Judith M. The Face of Exile: Autobiographical Journeys Reviewed by Claude P. Desmarais Redding, Arthur. Raids on Human Consciousness: Writing, Anarchism, and Violence Reviewed by Gail Finney Chambers, Ross. Facing It: AIDS Diaries and the Death of the Author Reviewed by Melissa A. Fitch Marx-Scouras, Danielle. The Cultural Politics of Tel Quel: Literature and the Left in the Wake of Engagement Reviewed by Diane Fourny Foster, David William. Buenos Aires: Perspectives on the City and Cultural Production Reviewed by Gustavo Geirola Nelson, Ardis L., ed. Guillermo Cabrera Infante: Assays, essays, and other arts Reviewed by José Luis Martinez-Dueñas Fox, Claire F. The Fence and the River: Culture and Politics at the U.S.-Mexico Border Reviewed by Robert Neustad
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