1,720,979 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Long Read Based Individual Molecule Sequencing and Real-time Pathogen Detection
No full textWith the ability to produce reads with hundreds of kilobases in length, long-read sequencing technology is emerging as a powerful tool to decode complex genetic sequences that are previously inaccessible for short reads. Though the sequencing chemistry and base calling algorithm are being actively developed, the accuracy of the current long-read sequencing is still considerably low, thus limiting its applications. In this dissertation, I present three long read based DNA sequencing methods to overcome the limitation of read accuracy, contribute to a better understanding of Cas9 editing outcomes and mitochondrial DNA heterogeneity, and pave the way for real-time pathogen detection and mutation surveillance.
The development of IDMseq enables the single-base-resolution haplotype-resolved quantitative characterization of diverse types of rare variants. IDMseq provides the first quantitative evidence of persistent nonrandom large structural variants following repair of double-strand breaks induced by CRISPR-Cas9 in human ESCs. The development of iMiGseq represents the first mitochondrial DNA sequencing method that provides ultra-sensitive variant detection, complete haplotyping, and unbiased evaluation of heteroplasmy levels, all at the individual mitochondrial DNA molecule level. iMiGseq uncovers unappreciated levels of heteroplasmic variants in single healthy human oocytes well below the current 1% detection limit, of which numerous variants are deleterious and associated with late-onset mitochondrial disease and cancer. It could comprehensively characterize and haplotype single-nucleotide and structural variants of mitochondrial DNA and their genetic linkage in NARP/Leigh syndrome patient-derived cells. The development of NIRVANA deals with the COVID-19 pandemic. NIRVANA can simultaneously detect SARS-CoV-2 and three co-infecting respiratory viruses, and monitor mutations for up to 96 samples in real time. It provides a promising solution for rapid field-deployable detection and mutation surveillance of pandemic viruses.
Taken all together, IDMseq, iMiGseq and NIRVANA utilize the advantage of long reads, overcome the limitation of low accuracy, and facilitate the application of long-read sequencing technologies in multidisciplinary fields
Targeted individual molecule sequencing enables the detection of ultra-rare variants
No full textTargeted individual molecule sequencing enables the detection of ultra-rare variants
Chongwei Bi, Lin Wang, Baolei Yuan, and Mo Li
Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal, KSA
Abstract
Genome contains hereditary information of the species, and its integrity is vital to life. With the developing of next-generation sequencing (NGS) technologies, we are gaining an unprecedented advance in decoding the genomic information in recent years. However, the current sequencing strategies are mainly population-based, in which samples come from DNA pools of bulk cells. They are not suitable for detecting rare mutations in a subpopulation of cells. Here we introduce targeted individual DNA molecule sequencing (IDMseq), which is a strategy to label and sequence individual DNA molecules from a pool. We applied IDMseq to detect rare mutations. Results showed that IDMseq is broadly applicable to any high-throughput sequencing platforms, and is capable to detect ultra-rare mutations at 1:10,000 allele frequency.
Conclusion
Inourpreliminaryworkwehave demonstrated that IDMseq is efficient and sensitive in detecting ultra-rare mutations, without limitation in the sequencing platform.
IDMseqalsoshowedtheability to detect somatic mutations within the genome. The somatic SNP load calculated from IDMseq is comparable with the published data2.
IDMseqwithlongamplicon showed the ability in detecting large SVs at allele resolution, which will potentially benefit other studies in the field
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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