1,225 research outputs found
Historical Fiction Author Don Neal Discusses Cold War Activities in Alaska
No full textDuring the Cold War, the USA was concerned that Russia would invade Alaska and American intelligence officers created the Stay Behind Agent Program to counter. At this event, Don Neal, author of the Ben Hunnicutt series that includes Cross Kill, Warhead, and washtub Gold, discusses the Nike missile system, the top-secret anti-espionage campaign Operation Washtub, and other Cold War activities in Alaska
Material Spirituality with Neal DeRoo Pt. I
No full textIs spirituality one part of our lives that we experience in worship? Or does it permeate our whole being? Are we able to pull spirituality and religion apart? What would happen if we considered how our spirituality is embodied, deeply, in our world? In this inaugural episode of Critical Faith, Neal DeRoo explores these questions in his lecture "Toward a Material Spirituality: Religion and Phenomenological Expression." The recording is the first of three parts, all from a Scripture, Faith, and Scholarship Seminar hosted at the Institute for Christian Studies.
Neal DeRoo is Canada Research Chair in Phenomenology and Philosophy of Religion and Associate Professor of Philosophy at The King's University in Edmonton, Alberta, and the author of Futurity in Phenomenology: Promise and Method in Husserl, Levinas, and Derrida (Fordham: 2013)
Grace Neal Parkway design concept report
No full textabstract: Grace Neal Parkway and Bank Street are located in the northern Kingman area partially outside of the Kingman city limits. This report discusses of creating a new arterial roadway providing safety and convenience for vehicular traffic and pedestrians. Although Grace Neal is referred to as a parkway, its designation for design is arterial.Stockton Hill Road to SR-66; Bank Street assessment, Northern Avenue to Grace Neal Parkway
From the Editor. Decription of author John Neal, his book Portland Illustrate
No full textFrom the Editor. Decription of author John Neal, his book Portland Illustrated (published in 1874), and his relationships with art critic N.C. Willis, Lady Blessington, and painter Charles Codman
Abstract 1858: Theranostic nanoparticles for detection and treatment of pancreatic cancer
No full textAbstract
Background: Despite continued efforts to improve early detection and treatment of pancreatic adenocarcinoma, the disease still carries a poor prognosis. The combination of multispectral optoacoustic tomography (MSOT) and theranostic nanoparticles offers a possible solution by providing tumor targeting using fluorescent dyes and treatment through drug delivery. We describe a 40 nm colloidal mesoporous silica nanoparticle (CMS) with vermiform pores and a chitosan coating and tagged with the V7 peptide to provide pH-specific dual targeting to deliver a contrast agent in a tumor-specific fashion.
Methods: CMSs were synthesized using a modified Stober method, coated with chitosan, and conjugated with a V7 peptide, resulting in a dual acidic pH targeting system. Particle characterization was performed using transmission electron microscopy (TEM), UV-vis spectrophotometry, Zeta potential, and dynamic light scattering . To determine acidic pH specificity of V7-CMS, Panc1 and S2VP10 cell lines were incubated in cell culture medium at either pH 7.4 or 6.6 followed by treatment with V7-CMS. Particle uptake was determined using near infrared (NIR) fluorescence and tissue phantoms. Finally, for in vivo testing, the same CMSNs were injected into mice bearing S2VP10 pancreatic tumors. MSOT imaging was performed 8 hours after CMS injection.
Results: TEM images demonstrated successful synthesis of approximately 40 nm V7-CMSs with vermiform pores. On NIR imaging, V7-CMS demonstrated acidic pH specificity in both S2VP10 and Panc 1 cells at pH 6.6, with particle localization and signal intensity 8-fold and 5-fold higher, respectively, than that observed at pH 7.4. In tissue phantoms, increased pH specificity was also observed in both S2VP10 and Panc 1 cells at pH 6.6. Particle location and signal intensity on MSOT was 20-fold and 4-fold higher, respectively, than that observed at pH 7.4. In the murine orthotopic S2VP10 pancreatic tumor model, MSOT imaging 8 hours after IV CMS injection demonstrated V7-CMS accumulation specifically within pancreatic tumors.
Conclusion: The acidic pH specific dual targeting system using chitosan-coated and pHLIP V7-tagged CMSs results in tumor specificity. Preferential binding and dye release was increased as much as 20-fold at pH 6.6 as compared to pH 7.4 in tissue phantoms. MSOT was able to detect tumor specific accumulation of V7-CMS in vivo. These small, pH specific particles hold significant promise for effectively identifying pancreatic tumors with high sensitivity and specificity and for targeted drug delivery.
Note: This abstract was not presented at the meeting.
Citation Format: Phillip Chuong, Neal Bhutiani, Lacey R. McNally. Theranostic nanoparticles for detection and treatment of pancreatic cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1858. doi:10.1158/1538-7445.AM2017-1858</jats:p
John Neal House (as City Motel), 1965
No full textFull exterior view of the John Neal House, 175 State Street, from southwest- east of Longfellow Square. At the time of this photograph, the building was known as The City Motel. The building was constructed in 1836, and was home to author and patron of the arts John Neal. The façade is made of Yarmouth granite, from a quarry purchased by Neal.
Photo published in the Evening Express, on 25 August 1965https://digitalcommons.portlandlibrary.com/pphnegs_images_business/1548/thumbnail.jp
Remembering Neal Miller
No full textAbstract
The author describes two encounters with Neal Miller, including a discussion of the pioneering curare/visceral learning experiments and of Miller's perspective on the biofeedback training paradigm.</jats:p
Neal Dow
No full textAn image scanned from a black and white lithograph by E. C. Kellogg of the Honorable Neal Dow, Mayor of Portland and author of the world renowned \u27Maine Law,\u27 an Act for the Suppression of Drinking Houses and Tippling-Shops, approved June 2nd, 1851.https://digitalcommons.library.umaine.edu/spec_photos/4253/thumbnail.jp
Material Spirituality with Neal DeRoo Pt. III
No full textIn the previous episode, Dean Dettloff interviewed DeRoo on his paper from episode one, "Material Spirituality," along with some general themes about Christian philosophy. In this episode, DeRoo takes questions from the audience, expressed by ICS student Grace Carhartt, on his paper and themes in the interview, engaging thinkers like Charles Taylor and William Cavanaugh and issues like ecclesiology and pluralism. The recording is the third and final of three parts, all from a Scripture, Faith, and Scholarship Seminar hosted at the Institute for Christian Studies. Neal DeRoo is Canada Research Chair in Phenomenology and Philosophy of Religion and Associate Professor of Philosophy at The King's University in Edmonton, Alberta, and the author of Futurity in Phenomenology: Promise and Method in Husserl, Levinas, and Derrida (Fordham: 2013)
'Christmas and New Years Poems'
No full textThis short volume of poems is titled "Christmas and New Years Poems." Written by Katharine Neal Smith, it includes a foreword by Flozari Rockwood and was Number 20 in a series called "Torchbearers' Chapbooks." Smith is also credited as the "Author of My 'Mother' Poems." This volume was hand-printed at Pegasus Studio in Cleveland, Ohio, and features numerous illustrations as well as a hand-cut cover block by Marguerite L. Fleury
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