1,577 research outputs found
Response to article “Effect of the Dynamic Orthotic Garment on Postural Control, and Endurance in Children with Spastic Diplegic Cerebral Palsy: A Randomized Controlled Trial” [Letter]
No full textPayal Mehta, Sandeep Pattnaik, Sunanda Bhowmik Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation, Maharishi Markandeshwar (Deemed to be University), Mullana, Haryana, 133207, IndiaCorrespondence: Sunanda Bhowmik, Email [email protected]
Proceedings of ASME Turbo Expo 2013: Power for Land, Sea and Air, Volume 1A: Combustion, Fuels and Emissions
No full textShahrokh Etemad (with Sandeep Alavandi and Benjamin Baird) is a contributing author, Fuel Flexible Rich Catalytic Lean Burn System for Low Btu Fuels
Triggering on electrons, photons, tau leptons, jets and energy sums with the CMS Level-1 trigger
No full textThe CMS Level-1 trigger architecture underwent a full upgrade in 2016 in order to maintain and improve the trigger performance in the challenging experimental environment of Run II. It uses very high bandwidth processors with complex, programmable algorithms which increase the efficiency of identifying physics objects while reducing rates. It has successfully delivered very high performance at the high luminosity and associated pile-up condition.The Compact Muon Solenoid (CMS) experiment implements a sophisticated two-level triggering system composed of the Level-1, instrumented by custom-design hardware boards, and a software High Level Trigger. A new Level-1 trigger architecture with improved performance is now being used to maintain high physics efficiency for the more challenging conditions experienced during Run II. In this poster, we present the upgraded CMS calorimeter trigger algorithms. The calorimeter trigger system plays a central role in achieving the ambitious physics program of Run II. The upgraded electronics architecture benefits from an enhanced granularity of the calorimeters to optimally reconstruct the trigger objects. Dedicated pile-up mitigation techniques are implemented for the lepton isolation, the jets and the missing transverse energy to keep the rate under control in the intense running conditions of the LHC. The performance of the new calorimeter trigger will be presented, based on proton-proton collision data collected in Run II. The selection techniques used to trigger efficiently on benchmark analyses will be presented, along with the strategies employed to guarantee efficient triggering for new resonances and other new physics signals
HPS@L1 algorithm for the upgraded CMS level-1 hadronic tau trigger for the HL-LHC
No full textThe High-Luminosity LHC will open an unprecedented window on the weak-scale nature of the universe, providing high-precision measurements of the standard model as well as searches for new physics beyond the standard model. The Compact Muon Solenoid (CMS) experiment is planning to replace entirely its trigger and data acquisition system to achieve this ambitious physics program. Efficiently collecting those datasets will be a challenging task, given the harsh environment of 200 proton-proton interactions per LHC bunch crossing. The new Level-1 trigger architecture for the HL-LHC will improve performance with respect to Phase I through the addition of tracking information and updates of the trigger electronics, which will allow to run a simplified particle-flow (PF) event reconstruction on the first trigger level (L1).In this proceedings, we present the development of an algorithm, which is one of many developed algorithms, to select events containing hadronic tau decays on L1 during LHC Phase II. The algorithm is inspired by the “hadrons-plus-strips” (HPS) algorithm, which has been used for the reconstruction of hadronic taus in offline analyses performed by CMS during LHC Runs 1 and 2. It takes advantage of the capability of the upgraded trigger to perform tracking and PF event reconstruction on L1 and is referred to as the HPS@L1 algorithm. The performance of the algorithm is studied in terms of efficiency and rate expected for a single hadronic tau and for a tau pair (di-tau) trigger, using simulated events. For a tau isolation selection that yields a plateau efficiency of 85\% per tau, the algorithm achieves a tau threshold of about 20 GeV for the di-tau trigger, which is lower than the threshold (32 GeV) achieved by the di-tau trigger (using calorimeter-only information) used by CMS during LHC Phase I (with luminosity )
Study of hadronic event-shape variables in multijet final states in pp collisions at 7 TeV
No full textEvent-shape variables, which are sensitive to perturbative and nonperturbative aspects of quantum chromodynamic (QCD) interactions, are studied in multijet events recorded in proton-proton collisions at TeV. Events are selected with at least one jet with transverse momentum GeV and pseudorapidity , in a data sample corresponding to integrated luminosities of up to . The distributions of five event-shape variables in various leading jet ranges are compared to predictions from different QCD Monte Carlo event generators
Acute Ethanol Administration Rapidly Increases Phosphorylation of Conventional Protein Kinase C in Specific Mammalian Brain Regions in Vivo
No full textBackground
Protein kinase C (PKC) is a family of isoenzymes that regulate a variety of functions in the central nervous system including neurotransmitter release, ion channel activity, and cell differentiation. Growing evidence suggests that specific isoforms of PKC influence a variety of behavioral, biochemical, and physiological effects of ethanol in mammals. The purpose of this study was to determine whether acute ethanol exposure alters phosphorylation of conventional PKC isoforms at a threonine 674 (p-cPKC) site in the hydrophobic domain of the kinase, which is required for its catalytic activity.
Methods
Male rats were administered a dose range of ethanol (0, 0.5, 1, or 2 g/kg, intragastric) and brain tissue was removed 10 minutes later for evaluation of changes in p-cPKC expression using immunohistochemistry and Western blot methods.
Results
Immunohistochemical data show that the highest dose of ethanol (2 g/kg) rapidly increases p-cPKC immunoreactivity specifically in the nucleus accumbens (core and shell), lateral septum, and hippocampus (CA3 and dentate gyrus). Western blot analysis further showed that ethanol (2 g/kg) increased p-cPKC expression in the P2 membrane fraction of tissue from the nucleus accumbens and hippocampus. Although p-cPKC was expressed in numerous other brain regions, including the caudate nucleus, amygdala, and cortex, no changes were observed in response to acute ethanol. Total PKC? immunoreactivity was surveyed throughout the brain and showed no change following acute ethanol injection
Four tops, SM and BSM by ATLAS and CMS, including EFT interpretations
No full textThis article presents the observation of four-top-quark () production in proton-proton collisions by the ATLAS and CMS experiments at the CERN LHC.
The analysis is performed using data samples collected by both experiments separately at a center-of-mass energy of 13 TeV during 2016-2018
and corresponding to an integrated luminosity of 140 and 138 by the ATLAS and CMS Collaborations respectively.
Events containing two leptons with the same electric charge or at least three leptons (electrons or muons) are selected.
Event kinematics are used to separate signal from background through a multivariate discriminant, and dedicated control regions are used to constrain the dominant backgrounds.
The observed (expected) significance of the measured signal with respect to the standard model (SM) background-only hypothesis
is 6.1 (4.3) standard deviations by the ATLAS and 5.6 (4.9) standard deviations by CMS experiment.
The production cross section is measured to be fb and fb by the ATLAS and CMS experiment respectively,
in agreement with the available standard model predictions.
Data are also used by the ATLAS experiment to set limits on the three-top-quark production cross section, being an irreducible background not measured previously,
and to constrain the top-Higgs Yukawa coupling and effective field theory operator coefficients that affect production
Search for di-Higgs boson production in multi-lepton final states at CMS
No full textThe results of a search for Higgs boson pair (HH) production in the , , and decay modes are presented. The search uses 138 of proton-proton collision data recorded by the CMS experiment at the LHC at a center-of-mass energy of 13 TeV from 2016 to 2018. Analyzed events contain two, three, or four reconstructed leptons, including electrons, muons, and hadronically decaying tau leptons. No evidence for a signal is found in the data. Upper limits are set on the cross section for non-resonant HH production, as well as resonant production in which a new heavy particle decays to a pair of Higgs bosons. For non-resonant production, the observed (expected) upper limit on the cross section at 95\% confidence level (CL) is 21.3 (19.4) times the standard model (SM) prediction. The observed (expected) ratio of the trilinear Higgs boson self-coupling to its value in the SM is constrained to be within the interval to 11.1 ( to 11.7) at 95\% CL, and limits are set on a variety of new-physics models using an effective field theory approach. The observed (expected) limits on the cross section for resonant HH production amount to pb at 95\% CL for new heavy-particle masses in the range GeV
Flavor Changing Neutral Current searches in the top quark sector
No full textFlavor changing neutral current (FCNC) interactions in top quark are highly suppressed in the Standard Model. Therefore, any measurable branching ratio for top FCNC decays is an indication of new physics. In this paper, searches for FCNC interactions in top quark production and decay at the LHC by the ATLAS Collaboration and the CMS collaboration are presented. FCNC searches in t qH, t q and t qZ decays, and in top quark production in qg t or q tg are summarized. None of the searches yielded positive results and exclusion limits on branching ratios, coupling strengths and cross-sections are obtained
Characterizing collagen mimetic peptides for orthogonal self-assembly
No full textA computational design of collagen mimetic peptides (CMPs) that self-assemble orthogonally (mutually exclusively), in the presence of other pre-existing collagen trimer mixtures, in vitro, has been proposed. The orthogonality in self-assembly was brought about by orthogonal patterning of ionic salt bridges and residues, along the collagen trimers’ axial length. Through the aid of circular dichroism spectroscopy alone, a novel experimental protocol was set-up to rapidly assess the level of cross-talk that may arise in such designed ‘heterogeneous monomer to trimer folding’ mixture environments. It is shown that the designed collagen mimetic peptides are stable and hetero-specific within their composite 3 chain peptide ecosystem. We experimentally demonstrate the extent to which loss in specificity could possibly occur, upon moving to a higher order ‘more than 3 monomers in solution’ peptide ensemble. Although the desired level of multi-state orthogonality was not achieved in the current design, the experimental results obtained were used to estimate the stability and specificity barrier threshold that one might run into, if one were to instead design orthogonal systems where-in specificity is incorporated during the computational design stage itself a priori. A Pareto frontier plot indicating the specificity versus stability trade-off is plotted. We conclude that a bottom-up design approach, incorporating design of specificity during the sequence design stage, would be a better way forward for achieving self-assembling orthogonality. In contrast to the complex chaperone assisted protein folding systems existing in nature, our method is a simplistic first step towards the complementary approach of modular synthetic collagen molecule design.Ph.D.Includes bibliographical referencesby Sandeep Vishwanath Belur
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