1,721,037 research outputs found
Effects of Ifenprodil on the Gating or NR1/2B NMDA Receptors
No full textThe extracellular amino terminal domain (ATD) of the NR2 subunits differentially controls NMDA receptor activity. Ifenprodil binds to the ATD of NR1/NR2B receptors inhibiting the receptors. To delineate the effects of ifenprodil on NR1/NR2B receptor gating, we recorded steady state currents from cell attached and excised outside out patches at pH7.9. NR1/NR2B receptors were found to exhibit modal gating in both forms of recording which was unaffected by ifenprodil. Ifenprodil increased the occupancy of the receptor in long-lived shut conformations hence reducing the open probability of receptor with no change in the mean open time. We found a negative correlation between the open and shut intervals in NR1/NR2B recordings from cell attached patches containing one active channel similar to those previously reported for NR1/NR2A receptors. In order to further understand actions of ifenprodil we fitted the single channel data to previously proposed models for NMDA receptor gating. Log likelihood criteria suggested that a cyclic model containing two uncoupled open states (Schorge et al. 2005) fitted the data better compared to a linear model with sequential open states. Ifenprodil modified multiple gating steps when fitted to an `uncoupled cyclic' model and promoted receptor desensitization. In contrast a single gating step was modified when single channel data was fitted to the `linear' gating model. Our results suggest an allosteric cross talk between the NR1 and NR2 subunits of the NMDA receptors.xiii, 78 page
Engineering ethics and the Drexel University Library: A collaborative teaching partnership
Get PDFBhatt, Jay and Manion, Mark and Fromm, Eli (2004) Engineering ethics and the Drexel University Library : a collaborative teaching partnership. In Proceedings of the American Society for Engineering Education Annual Conference & Exposition, Salt Lake City, Utah (US).At Drexel University, the present undergraduate engineering curriculum has evolved from the Enhanced Educational Experience for Engineering Students (E4) project and the Gateway Engineering Education Coalition, both National Science Foundation (NSF) funded initiatives to
re-engineer undergraduate engineering education. Since its institutionalization in 1994, the curriculum has served as a model for an integrated lower-division engineering curriculum. One aspect of engineering education proposed in this curriculum was “addressing ethics in the
context of an engineering issue”. To accomplish this goal, courses were designed with engineering ethics topics embedded within the syllabus. In parallel, the past decade has seen extensive growth in the number of electronic journals such as those from the IEEE, and electronic books available as subscription based library electronic resources. Along with the web, this has created an information overload that is now a major source of confusion among students. This paper discusses an effort to integrate these resources into coursework, as collaborative partnerships among the faculty, the library and students. We describe various materials used for teaching ethics, library created web-based instruction, librarian consultations with students to help them find various sources of information for
engineering ethics, and in the process target ABET requirements of lifelong learning
Library experience for applied engineering technology students
Get PDFBhatt, Jay, Genis, Vladimir and Roberts, Joshua. (2006). Library Experience for Applied Engineering Technology Students. In Proceedings American Society for Engineering Education Annual Conference & Exposition, Chicago, Illinois (US).The full-time Applied Engineering Technology Program at Goodwin College of Drexel University was launched two years ago. This program clearly distinguishes itself from traditional engineering programs. The curriculum places emphasis on the application of theory rather than on derivations and proofs. The majority of courses are fully integrated with training and laboratory experience, extensive use of software and industrial case studies. The information literacy of students plays an important role in the education process. The primary goal of an academic library is to support the curriculum and provide a more successful library experience for students. The communication between the librarian with liaison responsibilities and the academic program is described in this work. During the class-session of the Introduction to Applied Engineering Technology Course, the librarian introduces students to library resources including databases and electronic products, services, programs and policies, as well as to proper communication links between the library and the various colleges and schools. The information skills learned during the process contribute to life-long learning among the students in this program. Several activities such as research skills workshops, informal consultations, electronic reference and virtual chat, and informal mentoring are used to provide informative library experiences to the students. The role of the communication and collaboration among the faculty and the librarian to develop the content for the library skills workshops and assignments to assess the information skills learned are considered crucial for providing enriching library experience. The core information skills that will enhance the knowledge fundamentals form the central theme of this collaboration between the faculty, students, and librarians
Enhancing graduate online programs by using digital library services
No full textGenis, Vladimir, Bhatt, Jay, and Woodson, Shawn. (2012). Enhancing graduate online programs by using digital library services. In Proceedings of the American Society for Engineering Education Annual Conference & Exposition, San Antonio, Texas (US).The Master of Science in Engineering Technology (MSET) program was developed at Drexel University to provide a graduate level educational opportunity on a full- or part-time basis. The program is designed to be extremely flexible; it permits the student to select a combination of courses relevant to individual career goals in technology or to provide the foundation for further advanced study. The multidisciplinary curriculum includes core courses and electives in such
areas as rapid prototyping, programmable devices and systems, modern energy conversion
technologies, lean manufacturing principles, project management, to name a few. The program is currently available entirely online and several of the courses employ web-based laboratory exercises. Through collaboration with Drexel University Libraries, online instructional sessions
are planned, designed, and executed. These include: developing quality information seeking and research skills, keeping current with new research, and efficient management of quality references. With technologies available such as Web Conferencing, Chat Reference or Instant Messaging, Email Reference, Course Management System Integration, Blogs, Text Messaging
and Telephone service, distance learners receive necessary assistance needed for their projects and assignments through virtual environments. This also helps them discover a variety of information resources available through the Libraries’ website which otherwise they would not have known since they do not come to campus. The information skills learned during the process
contribute to life-long learning among the students in this new online program. Assessments mechanisms are envisioned to measure students acquired information skills
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Jelentés az IATUL 25. konferenciájáról
No full textTRUSSELL, Alice-BHATT, Jay: 25th IATUL Confe-rence Report. = Library Hi Tech News, 21. köt 8. sz. 2004. p. 4-7
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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