1,721,055 research outputs found

    Gli adolescenti tra reale e virtuale

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    Il volume affronta le varie sfaccettature delle problematiche adolescenziali, con una specifica curvatura sull'oggi: al centro delle considerazioni, il rapporto non dirado problematico con le istituzioni educative come la scuola e la famiglia, le questioni connesse all'immigrazione, il disagioe le relazioni sociali. I vari contributi, di accreditati sudiosi dell'adolescenza, e delle connesse tematiche psico-pedagogico-didattico, coniugano la parte riflessiva con le proposte operative e pratiche utili per docenti, educatori e famiglie. L'intento è quello di fornire strumento in grado di facilitare lo scambio intergenerazionale e di prevenire il disagio adolescenziale

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Genotoxic activity of methyl mercury chloride and dimethyl mercury in human lymphocytes

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    The genotoxicity of methyl mercury chloride (MMC, 0-25 X 10(-6) M) and dimethyl mercury (DMM, 0-434 X 10(-6) M) was evaluated by chromosome metaphase analysis in human lymphocytes treated in vitro for 24 h. Structural (CA) and numerical (AN) chromosomal aberrations were scored for the assessment of induced genotoxic effects, while the variation in mitotic index (MI) was considered a monitor for induced cellular toxicity. MMC induced CA and AN in a dose-related manner at doses exceeding 0.6 X 10(-6) M, and the proportion of cells with CA was constantly and significantly higher than that of cells with AN. DMM was able to induce both effects as well. although to a lesser extent than MMC, CA and AN being induced at doses exceeding 43.4 X 10(-6) M and 1.73 X 10(-6) M, respectively. MMC was 6-fold more effective in inducing CA than DMM at equivalent toxic doses. On the other hand, no significant difference was observed between the two compounds in inducing AN. Therefore MMC was much more clastogenic than DMM, whereas mitotic spindle disturbances appeared to be almost equally induced by both compounds

    Comparative studies on cytotoxic and genotoxic effects of two organic mercury compounds in lymphocytes and gastric mucosa cells of Sprague-Dawley rats

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    Human lymphocytes (HL) as well as lymphocytes (RL), hepatocytes (RH), and gastric mucosa cells (GM) of Sprague-Dawley rats were treated in vitro for 1 h with methylmercury chloride (MMC, 0.5-4 mug/ml) and dimethylmercury (DMM, 5-40 mug/ml). The cytotoxicity of the two organic mercury compounds was assessed by dye exclusion, and the extent of induced DNA fragmentation was measured with a single-cell microgel electrophoresis assay. Both MMC and DMM induced DNA damage and cytotoxicity in a dose-related manner in HL, RL, and GM. MMC was more effective in causing o significant increase in median DNA migration than DMM at doses yielding approximately the same degree of cytotoxicity. In rat hepatocytes the MMC-induced DNA damage was, however, lower than in the other cells. An analysis of repair kinetics following exposure to 2 mug/ml MMC was carried out in human lymphocytes obtained from an adult male donor. The bulk of DNA repair occurred 90 min after in vitro exposure, and it was about complete by 120 min following cessation of exposure. Finally, in order to have a basis for extrapolating to the human situation, in vivo studies were performed with Sprague-Dawley rats, also assessing the DNA damage and cytotoxicity in the lymphocytes and gastric mucosa cells. These in vivo results after oral exposure may be directly compared to the in vitro data obtained in the same cells

    Valutazione delle impurità solide in cracker tradizionali e integrali mediante filth-test

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    Due tipologie di cracker, prodotti con farina di frumento e con farina integrale, sono stati sottoposti ad analisi per controllarne il sudiciume, utilizzando la metodica stabilita dal D.M. del 23 luglio 1994 (“Metodi ufficiali di analisi dei cereali e derivati”). Per ognuna delle due gamme sono stati campionati cinque diversi marchi commerciali. Le indagini hanno evidenziato che nessuno dei campioni esaminati era esente da impurità che, per la maggior parte, erano costituite da fibre tessili, in particolare nel caso dei cracker integrali. Inoltre tre marche appartenenti a questa tipologia di prodotto hanno mostrato la presenza di peli di roditori. I frammenti di insetti sono stati trovati in nove prodotti dei dieci esaminati. L’identificazione delle impurità entomatiche ha permesso di riconoscere inquinamenti da Rhyzopertha dominica F. (Coleoptera Bostrychidae) e Sitophilus spp. (Coleoptera Dryophthoridae), specie che si sviluppano all’interno delle cariossidi. Inoltre le dimensioni di molti dei frammenti trovati hanno fatto ipotizzare che le infestazioni fossero precedenti la fase di molitura del cereale

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    The Comet Assay for the evaluation of the genetic hazard of pollutants on cetaceans. Preliminary results on the genotoxic effect of methylmercury on the bottle nosed dolphin (Tursiops truncatus)

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    In this study the single cell microgel electrophoresis (Comet assay) was used to evaluate the genetic effects of methylmercury in dolphin (Tursiops truncatns) lymphocytes in the dose range 1-8 mu g ml(-1). The results of in vitro exposure showed that methyl-Hg induces DNA single-strand breaks and cytotoxicity in a dose-dependent manner. Dolphin lymphocytes have greater resistance to the genotoxic and cytotoxic effects of methyl-Hg than human and rat cells. The ecological significance of these results are discusse

    Appropriate Similarity Measures for Author Cocitation Analysis

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    We provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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