1,721,880 research outputs found
Turn up the bass!: Low-frequency performance improvement of seismic attenuation systems and vibration sensors for next generation gravitational wave detectors
Full text linkBrand, J.F.J. van den [Promotor]Bertolini, A. [Copromotor
Early treatment with ACTH-(1-24) in haemorrhagic shock in humans: futher data
No full textIntroduction. We have previously shown that in patients with aortic dissection-induced haemorrhagic shock, the addition of an early intravenous injection of the melanocortin peptide ACTH-(1-24) (10 mg) to the standard treatment significantly increased survival rate (75% reduction in mortality) (1). Here we present the results obtained in a larger patient population, that confirm and strengthen the previous data. Materials and Methods. In our Cardiac Surgery Unit of Villa Maria Cecilia Hospital, all patients in haemorrhagic shock were consecutively enrolled in this study during the period 2002-2004 (112 subjects in all): 105 patients had aortic dissection (95 type A, 10 type B) and 7 patients had massive post-operative haemorrhage (mean estimated blood losses >5L). The European score was >15 and systolic blood pressure was 25% and neurologic complications in more than >20% of these patients, when subjected to the standard treatment alone.
References.
1. Noera G., Lamarra M., Guarini S. and Bertolini A. (2002) The Lancet 358: 469-470
2. Sinatra R., Melina G., Pulitani I., Fiorani B., Ruvolo G. and Macino B. (2001) Ann. Thorac. Surg. 71: 33-3
Grounding the case for a European approach to the regulation of automated driving: the technology-selection effect of liability rules
Full text linkIn the current paper, we discuss the need for regulation at EU level of Connected and Automated Driving solutions (henceforth CAD) based on multiple considerations, namely (i) the need for uniformity of criteria across European Member States, and (ii) the impact that regulation—or the absence of it—has on the proliferation of specific technological solutions. The analysis is grounded on legal and economic considerations of possible interactions between vehicles with different levels of automation, and shows how the existing framework delays innovation. A Risk-Management Approach, identifying one sole responsible party ex ante (one-stop-shop), liable under all circumstances—pursuant to a strict, if not absolute liability rule—is to be preferred. We analyse the solution adopted by some Member States in light of those considerations and conclude that none truly corresponds to a RMA approach, and differences will also cause market fragmentation. We conclude that because legal rules determine what kind of technological application is favoured over others—and thence they are not technology-neutral—uniformity across MSs is of essential relevance, and discuss possible policy approaches to be adopted at European level
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Pharmacokinetics of indomethacin in chronic migraine patients after withdrawal of the overused combination of indomethacin, prochlorperazine, and caffeine
No full textThe combination of indomethacin, prochlorperazine and caffeine (IPC) is often overused by migraine patients who develop medication-overuse headache (MOH), a secondary chronic headache that resolves after withdrawal of the overused medication. In a previous study (1) we showed that indomethacin clearance was lower in chronic migraine patients overusing IPC combination than in migraine patients only occasionally taking this combination. Objective: To verify if the reduced clearance of indomethacin reverts to normal after withdrawal of the overused IPC. Methods: We repeated the study of indomethacin pharmacokinetics in 9 female headache patients after 6 months from inpatient withdrawal of the IPC combination. In each patients indomethacin pharmacokinetics had been already studied before withdrawal treatment. The IPC combination (indomethacin 50 mg, prochlorperazine 8 mg, caffeine150 mg) habitually taken was administered by rectal route to each patient. Blood samples were drawn before dosing and at the following post-dose times: 0.5, 1, 2, 3, 4, and 6 h. Indomethacin concentrations were measured by HPLC method. Pharmacokinetic parameters were calculated by means of the P K Solutions 2.0 program. Results: The pharmacokinetic parameters of indomethacin in 4 patients (group A) who relapsed in IPC overuse were similar to those observed before withdrawal treatment; instead (Table 1) in 5 patients (group B) who steadily discontinued IPC combination, indomethacin disposition was significantly different from that observed before withdrawal treatment. Table 1. Pharmacokinetic parameters of indomethacin in group B. Parameter Before withdrawal After withdrawalHalf life (h) 2.74+0.98 1.45+0.34 *AUC0-t (mg/h/ml) 13.02+6.62 5.36+2.36 *Cl (ml/h/Kg) 64.05+30.16 123.98+39.91 *
*P <0.05 (paired Student’ t-test)Conclusions: In headache patients who discontinued IPC overuse, indomethacin clearance increased and reverted to values previously obtained in occasional IPC users (1).1. Ferrari A., Savino G., Gallesi D., Pinetti D., Bertolini A., Sances G., et al. (2006) Pharmacol Res. 542: 142-149
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
CyVar: Extending Var-At-Risk to ICT
No full textCyVar extends the Value-At-Risk statistics to ICT systems under attack by intelligent, goal oriented agents. CyVar is related to the time it takes an agent to acquire some access privileges and to the one it owns these privileges. To evaluate the former time, we use the security stress, a synthetic measure of the robustness of an ICT system. We approximate this measure through the Haruspex suite, an integrated set of tools that supports ICT risk assessment and management. After defining CyVar, we show how it supports the evaluation of three versions of an industrial control system
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