1,721,044 research outputs found

    HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties.

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    HTLV-1 and HTLV-2 share broad similarities in their overall genetic organization and expression pattern, but they differ substantially in their pathogenic properties. This review outlines distinctive features of HTLV-1 and HTLV-2 that might provide clues to explain their distinct clinical outcomes. Differences in the kinetics of viral mRNA expression, functional properties of the regulatory and accessory proteins, and interactions with cellular factors and signal transduction pathways are discussed

    The Tax protein of HTLV-II binds to the RelA/p65 subunit of NF-kB through interaction with its amino-terminal region.

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    The Tax protein of HTLV-II binds to the RelA/p65 subunit of NF-kB through interaction with its amino-terminal region
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