1,721,119 research outputs found
Prognostic and predictive response therapy factors in cancer disease (colorectal, breast, liver, lung, gastric, renal and prostate cancers)
No full textExploring prognostic and predictive response therapy factors in cancer disease is one of the most exciting issues of modern oncological science. Targeting intracellular signalling molecules is one of the novel approaches in which basic and translational researches meet clinical practice to define the best management of malignancies. The goal for target therapies is to identify agents that target tumor-specific molecules, thus sparing normal tissues. Those molecules are called biomarkers, and their identification is recommended for correct therapeutic planning. Hence, the contribution of clinical and surgical pathology to define cancer prognostic groups and treatment responsive tumors is essential not only for the efficacy of the cures, but also for ethical, economical, and social reasons. The promises of tailored (personalized) therapy are now almost certainly realistic and can give concrete hope to many cancer patients in the world. In this book, we have tried to describe the "state of art" in these fields of oncology, specifically considering prognostic and predictive response therapy factors in colorectal, breast, lung, gastric, renal, liver and prostate cancers
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Female form persistent mullerian duct syndrome: MDCT findings
No full textPersistent müllerian duct syndrome (PMDS) is a rare form of male pseudohermaphroditism. Two anatomic forms are described in this syndrome, the male and the female one; the second one is usually associated with bilateral cryptorchidism. About 150 cases are reported in literature; most of them are focused on anatomical, genetic, and surgical aspects. Radiological imaging features, important for diagnosis and therapy planification, are rarely reported. We describe a case of a female type of PMDS studied with multidetector computed tomography
Sfodera F. - LA SEGMENTAZIONE DELLA DOMANDA - Yield management – Uno strumento innovativo per la gestione dei ricavi nelle imprese turistiche - par. Strumenti di marketing e segmentazione del mercato
No full textL'articolo fornisce un contributo scientifico rilevante all'applicazione dello yield management in Italia e nel settore alberghiero in particolare. Il contributo di Sfodera fa luce sulle implicazioni di marketing e comunicazione per la gestione delle politiche di yield. Esso si focalizza tanto sulle conoscenze della domanda (segmentazione) necessarie a definire le classi di prezzo quanto sulle implicazioni in termini di commercializzazione e comunicazione dei prezzi e delle condizioni di vendita.The article provides a significant scientific contribution to the application of yield management in Italy and in the hospitality industry in particular. The contribution of Draw sheds light on the implications of marketing and communications for the management of policies of yield. It focuses so much on knowledge of the application (segmentation) necessary to define classes of price as on the implications in terms of marketing and communication of prices and conditions of sale
NEW ENTITIES IN THE TREATMENT OF HEPATOCELLULAR CARCINOMA: HIV-POSITIVE AND ELDERLY PATIENTS
No full textThe hepatocellular carcinoma (HCC) is the most common primary cancer of the liver and, according to the WHO report, the fourth commonest cause of death. The incidence of HCC has been rising in developed western countries in the last two decades, along with the emergence of hepatitis C virus infection and to the rise of immigration rates from HBV-endemic countries. In addition, even though the incidence of HCC reaches its highest peak among persons over 65 years, an increased incidence among younger individuals has been noted in the last two decades both in USA and Europe. In the last decades two kinds of HCC patients are more interesting, for clinical characteristics, than typical patients with HCC: elderly and HIV-positive patients. In fact due to the increase of the life expectancy in many countries, HCC represents a new challenge in this particular setting of patients
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
A New Proposal for the Pathogenic Mechanism of Non-Coeliac/Non-Allergic Gluten/Wheat Sensitivity: Piecing Together the Puzzle of Recent Scientific Evidence
No full textNon-coeliac/non-allergic gluten/wheat sensitivity (NCG/WS) is a gluten-related disorder,
the pathogenesis of which remains unclear. Recently, the involvement of an increased intestinal
permeability has been recognized in the onset of this clinical condition. However, mechanisms
through which it takes place are still unclear. In this review, we attempt to uncover these mechanisms
by providing, for the first time, an integrated vision of recent scientific literature, resulting in a new
hypothesis about the pathogenic mechanisms involved in NCG/WS. According to this, the root cause
of NCG/WS is a particular dysbiotic profile characterized by decreased butyrate-producing-Firmicutes
and/or Bifidobacteria, leading to low levels of intestinal butyrate. Beyond a critical threshold of the
latter, a chain reaction of events and vicious circles occurs, involving other protagonists such as
microbial lipopolysaccharide (LPS), intestinal alkaline phosphatase (IAP) and wheat -amylase
trypsin inhibitors (ATIs). NCG/WS is likely to be a multi-factor-onset disorder, probably transient
and preventable, related to quality and balance of the diet, and not to the presence of gluten in itself.
If future studies confirm our proposal, this would have important implications both for the definition
of the disease, as well as for the prevention and therapeutic-nutritional management of individuals
with NCG/WS
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