7 research outputs found
The biological and Mechanical Behavior of the Standard Implant under Removable Partial Dentures: Systematic Review:
Get PDFBackground: The implant-supported removable partial denture appears to be an interesting alternative for cases where the implant-supported fixed prosthesis is contraindicated whether it is for medical, local, or financial reasons. The objective of this systematic review is to evaluate the biological and mechanical behavior of the implant under a removable partial denture.Methods: A literature search was conducted on the following databases: Pubmed [Medline], Science Direct, and Cochrane Library. The research was limited to publications in English and French during the period from 01/1/2007 to 27/03/2020.Results: Of the 334 citations initially identified, 22 articles met our inclusion criteria, assessing the implant survival rate, patient satisfaction, and the occurrence of implant and prosthetic complications. As well as the evaluation of the stress distribution on the three support surfaces of this prosthesis. Finally, the evaluation of implant localization. The results showed a high rate of implant survival and the occurrence of some prosthetic complications. Stable and acceptable bone resorption over the long term. Better stress distribution at the implant and the bone.Conclusion: The biological and mechanical behavior of the implant under this type of prosthesis appears to be viable in the short, medium, and long term. Although this association between implantology and partial prosthesis seems promising, additional studies are needed to spread this practice still reserved for some specific cases
Arabic logic from al-Fārābī to Averroes: a study of the early Arabic categorical, modal, and hypothetical syllogistics
No full textThis monograph explores the logical systems of early logicians in the Arabic tradition from a theoretical perspective, providing a complete panorama of early Arabic logic and centering it within an expansive historical context. By thoroughly examining the writings of the first Arabic logicians, al-Fārābī, Avicenna and Averroes, the author analyzes their respective theories, discusses their relationship to the syllogistics of Aristotle and his followers, and measures their influence on later logical systems. Beginning with an introduction to the writings of the most prominent Arabic logicians, the author scrutinizes these works to determine their categorical logic, as well as their modal and hypothetical logics. Where most other studies written on this subject focus on the Arabic logicians’ epistemology, metaphysics, and theology, this volume takes a unique approach by focusing on the actual technical aspects and features of their logics. The author then moves on to examine the original texts as closely as possible and employs the symbolism of modern propositional, predicate, and modal logics, rendering the arguments of each logician clearly and precisely while clarifying the theories themselves in order to determine the differences between the Arabic logicians’ systems and those of Aristotle. By providing a detailed examination of theories that are still not very well-known in Western countries, the author is able to assess the improvements that can be found in the Arabic writings, and to situate Arabic logic within the breadth of the history of logic. This unique study will appeal mainly to historians of logic, logicians, and philosophers who seek a better understanding of the Arabic tradition. It also will be of interest to modern logicians who wish to delve into the historical aspects and progression of their discipline. Furthermore, this book will serve as a valuable resource for graduate students who wish to complement their general knowledge of Arabic culture, logic, and sciences
Epidemiology and phenotypes of multiple sclerosis in the Middle East North Africa (MENA) region
Get PDFThe Middle East North Africa (MENA) region falls in the low-to-moderate multiple sclerosis (MS) prevalence zone, with prevalence rates slightly lower than Southern Europe but much higher than sub-Saharan Africa. However, there is clearly a trend toward increased MS prevalence over the last few decades, consistent with the globally rising prevalence of the disease. We analyzed all data collected from the MENACTRIMS (Middle East North Africa Committee for Treatment and Research in Multiple Sclerosis) registry by the end of December 2018. A total of 6885 patients were eligible for the study. Overall, the clinical phenotype of MS in the MENA region was not different from the Western phenotype except for earlier age at onset and a more aggressive clinical course leading to earlier disability. © The Author(s) 2020
Femtosecond pulsed laser microscopy: a new tool to assess the in vitro delivered dose of carbon nanotubes in cell culture experiments
No full textBackground In vitro models are widely used in nanotoxicology. In these assays, a careful documentation of the fraction of nanomaterials that reaches the cells, i.e. the in vitro delivered dose, is a critical element for the interpretation of the data. The in vitro delivered dose can be measured by quantifying the amount of material in contact with the cells, or can be estimated by applying particokinetic models. For carbon nanotubes (CNTs), the determination of the in vitro delivered dose is not evident because their quantification in biological matrices is difficult, and particokinetic models are not adapted to high aspect ratio materials. Here, we applied a rapid and direct approach, based on femtosecond pulsed laser microscopy (FPLM), to assess the in vitro delivered dose of multi-walled CNTs (MWCNTs). Methods and results We incubated mouse lung fibroblasts (MLg) and differentiated human monocytic cells (THP-1) in 96-well plates for 24 h with a set of different MWCNTs. The cytotoxic response to the MWCNTs was evaluated using the WST-1 assay in both cell lines, and the pro-inflammatory response was determined by measuring the release of IL-1 beta by THP-1 cells. Contrasting cell responses were observed across the MWCNTs. The sedimentation rate of the different MWCNTs was assessed by monitoring turbidity decay with time in cell culture medium. These turbidity measurements revealed some differences among the MWCNT samples which, however, did not parallel the contrasting cell responses. FPLM measurements in cell culture wells revealed that the in vitro delivered MWCNT dose did not parallel sedimentation data, and suggested that cultured cells contributed to set up the delivered dose. The FPLM data allowed, for each MWCNT sample, an adjustment of the measured cytotoxicity and IL-1 beta responses to the delivered doses. This adjusted in vitro activity led to another toxicity ranking of the MWCNT samples as compared to the unadjusted activities. In macrophages, this adjusted ranking was consistent with existing knowledge on the impact of surface MWCNT functionalization on cytotoxicity, and might better reflect the intrinsic activity of the MWCNT samples. Conclusion The present study further highlights the need to estimate the in vitro delivered dose in cell culture experiments with nanomaterials. The FPLM measurement of the in vitro delivered dose of MWCNTs can enrich experimental results, and may refine our understanding of their interactions with cells.This work was supported by the Fonds de la Recherche scientifique - FNRS [Convention de recherche ERA-NET - No R.50.17.16.F], the Flemish Scientific Research Foundation [FWO; HB: 12P6819N], the U.S.A. National Science Foundation [grant CBET-1530505], and the German BMBF (FKZ: 03XP0063).Lison, D (corresponding author), Catholic Univ Louvain, Louvain Ctr Toxicol & Appl Pharmacol LTAP, Inst Rech Expt & Clin IREC, Brussels, Belgium.
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Cardiovascular imaging research and innovation in 2023
Get PDF© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.In 2023, cardiovascular imaging has made significant advancements, in terms of technology, pathophysiology, and clinical application. In this review, the most recent research findings in the field of cardiovascular imaging are discussed. Artificial intelligence and large population cohorts, together with several technical improvements, have had a crucial impact on the technological advancements of echocardiography, cardiovascular magnetic resonance, computed tomography (CT), and nuclear medicine. In the field of ischaemic heart disease, it has been demonstrated that appropriate non-invasive imaging strategies improve patients' management and reduce invasive procedures and the need for additional testing at follow-up. Moreover, improvements in plaque characterization with CT are an expanding field of research with relevant implications for the prediction of disease severity, evolution, and response to treatment. In the field of valvular heart disease, imaging techniques have advanced alongside improvements in transcatheter treatment for aortic stenosis, mitral, and tricuspid regurgitation. Finally, in the field of heart failure and cardiomyopathies, cardiovascular imaging has reinforced its crucial role in early diagnosis and risk evaluation, showcasing advanced techniques that outperform traditional methods in predicting adverse outcomes.publishersversionpublishe
Author Correction: Effect of ticagrelor and prasugrel on remote myocardial inflammation in patients with acute myocardial infarction with ST-elevation: a CMR T1 and T2 mapping study (The International Journal of Cardiovascular Imaging, (2022), 39, 4, (767-779), 10.1007/s10554-022-02765-y)
No full textIn the original publication of the paper Table 1 is mixed up and the references incorrectly published. The corrected Table 1 and reference is given in this Correction. (Table presented.) Patient characteristics Ticagrelor (n = 29) Prasugrel (n = 31) p-value Age, years 62.2 ± 10.7 61.6 ± 9.5 0.81 Male, n (%) 23 (79.3) 26 (83.9) 0.75 BMI, kg/m 2 27.6 ± 3.9 27.0 ± 3.9 0.54 Medical history, n (%) Hypertension 10 (34.5) 5 (16.1) 0.14 Diabetes mellitus 3 (10.3) 2 (6.5) 0.67 Smoking 15 (51.7) 16 (51.6) 0.99 Current 10 (66.7) 11 (68.8) In the past 5 (33.3) 5 (31.3) Hypercholesterolaemia 3 (10.3) 7 (22.6) 0.30 Prior chronic coronary syndrome 2 (6.9) (0) 0.23 Prior PCI 2 (6.9) PCI-related vessel LAD 1 (3.2) LCX 0 (0) RCA 1 (3.2) In-stent restenosis as culprit lesion (0) Family history of CAD 7 (24.1) 12 (38.7) 0.27 Medication at baseline, n (%) Acetylsalicylic acid 3 (10.3) 1 (3.2) 0.35 β-blocker 4 (13.7) 1 (3.2) 0.18 ACE-i 3 (10.3) 0 (0) 0.11 ARB 4 (13.8) 2 (6.5) 0.42 Calcium antagonist 2 (6.9) 3 (9.7) 1.00 Diuretic 5 (17.2) 0 (0) < 0.01 Lipid lowering medication 3 (10.3) 5 (16.1) 0.71 Anti‐inflammatory drugs 3 (10.3) 3 (9.7) 1.00 Coronary angiography Symptom onset to wire crossing time, min 161 [123 – 494] 122 [96 – 240] 0.07 Culprit artery, n (%) 0.87 LAD 7 (24.1) 9 (29.0) LCX 7 (24.1) 8 (25.8) RCA 15 (51.7) 14 (45.2) Medication at hospital discharge, n (%) Acetylsalicylic acid 29 (100) 31 (100) 1.00 β-blocker 26 (89.7) 29 (93.5) 0.67 ACE-i 22 (75.9) 23 (74.2) 1.00 ARB 5 (17.2) 2 (6.5) 0.25 Calcium antagonist 0 (0) 0 (0) 1.00 Diuretic 1 (3.4) 1 (3.2) 1.00 Lipid lowering medication 28 (96.6) 31 (100) 0.48 Anti‐inflammatory drugs 2 (6.9) 2 (6.5) 1.00 Values are presented as mean ± standard deviation, median [IQR] or absolute number (%) and assessed by independent-samples T test, Mann–Whitney U test, or Chi-square test, respectively ACE-i angiotensin converting enzyme inhibitors; ARB angiotensin II receptor blockers; BMI body mass index; CAD coronary artery disease; LAD left anterior descending coronary artery; LCX left circumflex coronary artery; RCA right coronary artery The original article has been corrected
Effective for Whom? A Review of Psychological and Social Intervention Recommendations in European Dementia Care Guidelines Through the Lenses of Social Health and Intersectionality
Get PDFFunding Information: This research was funded by the Health Research Board [JPND-WG-2022-1]. It is an EU Joint Programme\u2014Neurodegenerative Disease Research (JPND) project supported under the aegis of JPND\u2014www.jpnd.eu. For C.G., this is independent research funded by the National Institute for Health and Care Research Applied Research Collaboration North West Coast (ARC NWC). The views expressed in this publication are those of the author(s) and not necessarily those of the National Institute for Health and Care Research or the Department of Health and Social Care. Publisher Copyright: © 2025 by the authors.In dementia care, access to effective psychosocial interventions is often addressed by evidence-based guidelines for care providers. However, it is unclear if current guidelines consider personal characteristics that may impact intervention effectiveness. This study investigates if, and within what framing, dementia care guidelines in Europe address what is effective and for whom. A review of 47 guidelines from 12 European countries was conducted. Content analysis focused on (i) if guidelines recommended specific psychosocial interventions, and how guidelines referred to (ii) social health, (iii) the intersection of social positioning, and (iv) inequities in care or outcomes. Thirty-five guidelines (74%) recommended specific psychosocial interventions. Around half referenced aspects of social health and of intersectionality. Thirteen guidelines (28%) referenced inequities. Social health was not explicitly recognised as a mechanism of psychosocial interventions. Only age and comorbidity were consistently considered to impact interventions’ effectiveness. Inequities were acknowledged to arise from within-country regional variations and individual economic status, but were not linked to (intersectional) individual societal positions such as sex and/or gender, sexuality, and/or religion. The results between European countries were heterogeneous. Current guidelines offer little insight into what works for whom. Policymakers and guideline developers should work with researchers, generating and translating evidence into policy.publishersversionpublishe
