1,721,040 research outputs found
May home confinement during the COVID-19 outbreak worsen the global burden of myopia?
No full textNo abstract availabl
Sine musica nulla disciplina... Studi in onore di Giulio Cattin
No full textIl volume contiene una serie di contributi di musicologi e colleghi di Giulio Cattin, italiani e di altre nazionalità, che intendono rispecchiare la personalità dello studioso così come essa è emersa nell'ambito delle sue ricerche scientifiche e in quello delle relazioni sociali e accademiche.
Ai contributi musicologici, che producono nuove informazioni sulle tematiche care a Cattin (il canto piano, le prime forme di polifonia d'arte, le forme della poesia per musica dell'Umanesimo, i repertori liturgico-musicali di Padova e Venezia, la tradizione della laude in volgare), si affiancano quelli dei suoi colleghi presso l'Università di Padova che, con studi originali, richiamano i suoi interessi per la filologia, l'italianistica e la storia dell'arte. Completa la pubblicazione la bibliografia degli scritti di Giulio Cattin
Impact of cataract surgery on depression and cognitive function: Systematic review and meta-analysis
Full text linkImportance: In elderly people, visual impairment is associated with depressive symptoms and cognitive decline. However, the impact of cataract surgery on depression and cognitive impairment is still controversial. Background: To evaluate the effect of cataract surgery on depression and cognitive status in the elderly. Design: This study was a meta-analysis. Participants: Patients with age-related cataract who underwent cataract surgery were recruited for this study. Methods: A literature search was performed on PubMed, Scopus and Web of Science. Data were extracted from selected studies by two independent reviewers. The pooled standardized mean difference (SDM) was estimated using a random-effects model. Heterogeneity was evaluated using the Q and I2 tests. Multiple sensitivity analyses and assessment of publication bias were performed. Main Outcome Measures: The main outcome was a report of a measure of depression or cognitive impairment before and after surgery. Results: Sixteen studies were included: 14 of them reported data on depression and 9 of them on cognitive function. Depression significantly decreased after surgery (SDM = 0.460; 95% CI: 0.223-0.697; P <.001). In six controlled studies, the reduction of depression was higher in the surgery group than in the control group (SDM = 0.161; 95% CI: 0.027-0.295; P =.019). Cognitive function significantly improved after surgery (SDM = 0.254; 95% CI: 0.120-0.388; P <.001). In four controlled studies, the improvement of cognitive function was higher in the surgery group than in the control group (SDM = 0.188; 95% CI: 0.002-0.374; P =.048). Results were stable after sensitivity analyses. Conclusions and Relevance: This meta-analysis provides evidence that cataract surgery has a positive effect on depression and cognitive function in the elderly
Capitolo 2 IL MEIBUM – Composizione biochimica, lipidi e contributo a composizione e stabilità del film lacrimale
No full textIl ruolo delle ghiandole di Meibomio nella patogenesi di vari disturbi della superficie oculare, quali blefarite cronica e malattia dell’occhio
secco è ben conosciuto. Le ghiandole di Meibomio sono localizzate a livello del tarso sia della palpebra superiore che di quella inferiore e
i loro orifizi sono localizzati a livello del bordo palpebrale. La secrezione delle ghiandole di Meibomio è rappresentata da una sostanza oleosa
denominata meibum, che viene distribuita sulla superficie del film lacrimale, ad ogni ammiccamento, andandone a costituire lo strato lipidico
Ocular surface system alterations in ocular graft-versus-host disease: all the pieces of the complex puzzle
No full textPURPOSE: Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cells transplantation, occurring in about half of transplanted patients. This condition seems to be the result of a progressive immune-mediated damage that can involve various tissues, including the eyes. The ocular surface system is the ocular structure most frequently impaired, and dry eye disease is considered the hallmark of ocular GVHD. Given the increasing prevalence and the frequent severe involvement of the ocular surface with vision-threatening complications, ocular GVHD represents a current diagnostic and therapeutic challenge. The purpose of this literature review is to describe all the clinical manifestations occurring in the setting of ocular GVHD, and to further report the outcomes of conventional and novel therapies. METHODS: A literature search about ocular GVHD was performed in PubMed, Scopus, Medline databases, and ClinicalTrials.gov as well as through the reference lists of identified publications until January 2019. We have included RCTs, prospective observational studies, prospective and retrospective cohort studies, pilot studies, and review articles. RESULTS: Overall, 107 articles, 3 book chapters, and 6 ongoing registered clinical trials were collected and analyzed. Ocular GVHD can affect all the structures of the entire ocular surface system, including lacrimal and meibomian glands, cornea, conjunctiva, eyelids, nasolacrimal duct, and tears. Current medical treatment is mainly focused on lubrication and control of drainage, tear evaporation, and ocular surface inflammation. Surgical treatment may be necessary in severe, recalcitrant, or complicated cases. Amniotic membrane and tectonic keratoplasty can be valid options to restore the integrity of the cornea. Recently, conjunctival and limbal transplantation from the same living-related bone marrow donor has been proposed to manage both dry eye and limbal stem cell deficiency, without any risk of immunologic rejection. CONCLUSION: This review provides an up-to-date analysis on clinical findings and current and future management of ocular GVHD. A correct and prompt diagnosis along with an appropriate and aggressive treatment are fundamental for avoiding the occurrence of vision-threatening complications
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Obstructive Sleep Apnea and Keratoconus: A Systematic Review and Meta-analysis.
Full text linkBACKGROUND: Despite the increasing number of studies focused on the association between obstructive sleep apnea (OSA) and keratoconus (KC), to date, no comprehensive meta-analysis or systematic review was published. OBJECTIVE: The objective of this study was to evaluate the association between OSA and KC. DATA SOURCES: Sources of data were PubMed, Scopus, and Web of Science databases. STUDY ELIGIBILITY CRITERIA: The criteria for study eligibility were case-control studies and cohort studies reporting data on the association of OSA with KC with risk ratio, odds ratio, or hazard ratio with 95% confidence intervals or sufficient raw data for calculation. STUDY APPRAISAL AND SYNTHESIS METHODS: Meta-analysis was conducted with a random-effects model using odds ratio with 95% confidence interval as the effect size. Heterogeneity was evaluated using the Q and I tests. Sensitivity analysis and assessment of publication bias were performed. RESULTS: Five studies (four case-control studies and one cohort study) published between 2012 and 2016 and involving 33,844 subjects (16,922 patients with KC, 16,922 controls) were included in this meta-analysis. A significant association between OSA and KC has been shown (pooled odds ratio, 1.841; 95% confidence interval, 1.163 to 2.914; P = .009). A significant heterogeneity was observed (Q = 15.8, I = 74.6%). There was no evidence of significant publication bias (P = .07). The sensitivity analyses indicated the stability of results. LIMITATIONS: Heterogeneity across the studies was observed. Data from four hospital-based case-control studies and one large population-based cohort study were combined. Most of the included studies ascertained OSA by the Berlin Questionnaire, which is a screening tool. CONCLUSIONS: This meta-analysis provides significant evidence that OSA is associated with KC. Therefore, a proper screening for OSA is warned for KC patients for the prevention of various cardiovascular comorbidities. Further prospective studies are warranted to explore more in-depth the casual relationship between the two conditions
Performance Analysis of Delta Networks.
No full textAn analytical model for evaluating performance of Delta networks is presented. The networks are supposed to operate with the packet switching technique. The proposed model is not constrained by increasing both the dimension of the basic switching element and the buffer size. The theoretical approach is characterized by a complete logical separation between the basic switching element model and the whole network one. The first one is analyzed by means of discrete time Markov chain, whereas the second one has been solved by means of numerical techniques. The data collected via the analytical approach are compared with the correspondent simulative values. The comparison between the two sets of data allows to assess the influence of the hypotheses assumed in the analytical model
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