162 research outputs found
ISOLASI DAN KARAKTERISASI SENYAWA KIMIA DARI EKSTRAK n-HEKSAN KULIT BATANG Garcinia rigida
No full textIsolation and Characterization Chemical Compounds from the Brak of Garcinia rigida. Garcinia rigida is an Indonesia original plant growing on Sumatera, Java, Kalimantan, and Maluku. Most of its genus have been researched and proven as medicinal plants. Two compounds have been isolated from n-hexane stem-bark of Garcinia Rigida. The two compounds are Stigmasterol (compound A) and a triterpen oleanolic acid (compound B).Keywords: Garcinia rigida, stogmasterol, triterpen, oleanolic acid
Fractionation and antioxidant activity potency of the extract of Garcinia lateriflora Blume var. javanica Boerl leaf
No full textISOLASI DAN KARAKTERISASI SENYAWA KIMIA DARI EKSTRAK n-HEKSAN KULIT BATANG Garcinia rigida
Get PDFGarcinia rigida, stogmasterol, triterpen, oleanolic acid
UNRIPE FRUIT OF RUBUS FRAXINIFOLIUS AS A POTENTIAL SOURCE OF ANTIOXIDANT AND ANTIELASTASE AGENT
Get PDFObjective: This research aimed to examine the anti-oxidant activity, antielastase activity, and the content of total phenolic and total flavonoid of R. fraxinifolius unripe fruit.
Methods: The dried unripe fruit was extracted using Soxhlet apparatus with sequence solvent: n-hexane, ethyl acetate, and methanol. Each extract was determined the anti-oxidant and antielastase activity, total phenolic, and total flavonoid content.
Result: The result showed the extracts (n-hexane, ethyl acetate, and methanol) gave anti-oxidant IC50>200; 186.84; and 19.74 ppm, and the ability of elastase inhibition was 6.84+0.9%; 52.23+7.1%; and 57.81+5.5% at 100 ppm, respectively. The methanolic extract contained phenolic 202.2 mg GAE/g extract and flavonoid 43.89 mg QE/g extract.
Conclusion: R. fraxinifolius unripe fruit has shown potential as a DPPH (α, α-diphenyl-β-picrylhydrazyl) radical scavenger and anti-elastase. This study provides an excellent effect to underline the importance of R. fraxinifolius unripe fruit, and it can be developed as nutricosmetics, nutraceuticals, or herbal anti-wrinkle cosmetics
Acute Toxicity of Justicia gendarussa Burm. Leaves
No full textAcute Toxicity of Justicia gendarussa Burm. Leaves. Preminelary experiment showed that ethanolic extract ofgandarusa leaves (Justicia gendarussa Burm.) could decreased uric acid blood level on rats. The aim of this experimentwas to determine of the value LD50 and liver function based on activities of aminotransferase. Animals test which wereused in this experiment were 50 males and 50 females white mice. They were divided into 5 groups. Group 1 as controlgroup was given aquadest. Group 2-5 were treated by ethanolic extract of gandarusa leaves with dosage 4, 8, 16, and 32g/kg bw. The LD50 value was determined by the amount of death in group during 24 hours after giving a single dose oftest substance. The result showed that the highest dose was practically non toxic with LD50 value of 31.99 g/kg bw(male groups) and 27.85 g/kg bw (female groups). Measurement of aminotransferase activity was done by usingcolorimetric method. The result of ANOVA analysis for liver function showed that the giving test substance 4 g/kg bw–16 g/kg bw was not significantly different between treated groups and control group
The Investigation for Antifungal Effect of Medicinal Plants, Combination Infusion of Piper Bettle Leaves, Punica Granatum Fructus Cortec, Curcuma Domestica Rhizome
No full textThe tested demartophyta used Candida albicans. This research using dilution method to determine of minimum inhibitory concentration (MIC) and difusion method to determine zone inhibition around of disc. The results of determination of MIC showed that combination infusion Piper bettle leaves with Punica granatum Fructus Cortex against C. albicans respectively, 31,2 mg/ml : 7,8 mg/ml; 15,6 mg/ml : 15,6 mg/ml and 7,8 mg/ml : 31,2 mg/ml. The determination for zone inhibition from 3 concentration of infusion of Piper bettle leaves with 3 concentration of Punica granatum Fructus Cortex with 9 combination against C. albicans showed that combination of two infusion is the larger than the single infusion
UJI PENDAHULUAN EFEK KOMBINASI ANTIJAMUR INFUS DAUN SIRIH (Piper betle L.), KULIT BUAH DELIMA (Punica granatum L.), DAN RIMPANG KUNYIT (Curcuma domestica Val.) TERHADAP JAMUR CANDIDA ALBICANS
Get PDFThe investigation for antifungal effect of medicinal plants, combination infusion of Piper bettle leaves, Punica granatum Fructus Cortec, Curcuma domestica Rhizome. The tested demartophyta used Candida albicans. This research using dilution method to determine of minimum inhibitory concentration (MIC) and difusion method to determine zone inhibition around of disc. The results of determination of MIC showed that combination infusion Piper bettle leaves with Punica granatum Fructus Cortex against C. albicans respectively, 31,2 mg/ml : 7,8 mg/ml; 15,6 mg/ml : 15,6 mg/ml and 7,8 mg/ml : 31,2 mg/ml. The determination for zone inhibition from 3 concentration of infusion of Piper bettle leaves with 3 concentration of Punica granatum Fructus Cortex with 9 combination against C. albicans showed that combination of two infusion is the larger than the single infusion
UJI PENDAHULUAN EFEK KOMBINASI ANTIJAMUR INFUS DAUN SIRIH (Piper betle L.), KULIT BUAH DELIMA (Punica granatum L.), DAN RIMPANG KUNYIT (Curcuma domestica Val.) TERHADAP JAMUR CANDIDA ALBICANS
No full textTheinvestigation for antifungal effect of medicinal plants, combination infusion of Piper bettle leaves, Punicagranatum Fructus Cortec, Curcuma domestica Rhizome. The tested demartophyta used Candida albicans. This research using dilution method to determine of minimum inhibitory concentration (MIC) and difusion method to determine zone inhibition around of disc. The results of determination of MIC showed that combination infusion Piper bettle leaves with Punica granatum Fructus Cortex against C. albicans respectively, 31,2 mg/ml : 7,8 mg/ml; 15,6 mg/ml : 15,6 mg/ml and 7,8 mg/ml : 31,2 mg/ml. The determination for zone inhibition from 3 concentration of infusion of Piper bettle leaves with 3 concentration of Punica granatum Fructus Cortex with 9 combination against C. albicans showed that combination of two infusion is the larger than the single infusion.Keywords: Punica granatum, Curcuma domestica, infeksi jamur Candida, antifungi Piper betl
Arginase Inhibitory, Antioxidant Activity and Pharmacognosy Study of Sterculia macrophylla Vent. Leaves
Get PDFObjective: The purpose of this study was to investigate the arginase inhibitory activity, antioxidant
activity, and also pharmacognostical study of Sterculia macrophylla leaves. The main
component of genus Sterculia was flavonoid that was well known to demonstrate arginase
inhibitory activity. Methods: Sample was extracted gradually using n-hexane, ethyl acetate,
and methanol solvents, subsequently. The n-hexane, ethyl acetate, and methanol extract
were determined for their arginase inhibitory activity. The most active extract was methanol
extract. This extract was determined for its antioxidant activity, arginase inhibitory activity,
identification of chemical compound, chromatogram profile and determined the content of
total flavonoid. The leaves and powder of Sterculia macrophylla were identified with microscopic
and macroscopic evaluation. Results: The most active extract was methanol extract
with IC50 114,659 μg/mL for arginase inhibitory activity and IC50 78.47 μg/mL for DPPH scavenging
activity. The secondary metabolite of methanol extract presence compound of alkaloid,
flavonoid, tannin, terpene, and glycoside. The total flavonoid content was 141.10 mg/gram
extract. The star-shape trichoma was identified as a specific fragment. Conclusion: The methanol
extract of Sterculia macrophylla showed activity as arginase inhibitor and antioxidant.
Key words: Arginase, Antioxidant, Flavonoid, Pharmacognostical, Sterculia macrophylla
- …
