1,720,973 research outputs found
Potent ribonucleotide reductase inhibitors: Thiazole-containing thiosemicarbazone derivatives
Full text linkSAHIN, ZAFER/0000-0002-5976-676X; Berk, Barkin/0000-0001-6047-2796WOS: 000484830900001PubMed: 31475759The antioxidant, antimalarial, antibacterial, and antitumor activities of thiosemicarbazones have made this class of compounds important for medicinal chemists. in addition, thiosemicarbazones are among the most potent and well-known ribonucleotide reductase inhibitors. in this study, 24 new thiosemicarbazone derivatives were synthesized, and the structures and purity of the compounds were determined by IR, H-1 NMR, C-13 NMR, mass spectroscopy, and elemental analysis. the IC50 values of these 24 compounds were determined with an assay for ribonucleotide reductase inhibition. Compounds 19, 20, and 24 inhibited ribonucleotide reductase enzyme activity at a higher level than metisazone as standard. the cytotoxic effects of these compounds were measured on the MCF7 (human breast adenocarcinoma) and HEK293 (human embryonic kidney) cell lines. Similarly, compounds 19, 20, and 24 had a selective effect on the MCF7 and HEK293 cell lines, killing more cancer cells than cisplatin as standard. the compounds (especially 19, 20, and 24 as the most active ones) were then subjected to docking experiments to identify the probable interactions between the ligands and the enzyme active site. the complex formation was shown qualitatively. the ADME (absorption, distribution, metabolism, and excretion) properties of the compounds were analyzed using in-silico techniques.Anadolu University Scientific Research Projects CommissionAnadolu University [1609S624]Anadolu University Scientific Research Projects Commission, Grant/Award Number: 1609S62
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Effects of Nonsteroidal Anti-inflammatory Drugs on Chondrogenic Differentiation
Full text linkBACKROUND: NSAIDs represent a large class of drugs used for their analgesic and anti-inflammatory effects. Background Nevertheless, their effects on chondrogenic differentiation are not known. The present study examines the potential effects of five different NSAIDs, namely Etodolac, Dexketoprofen, Acetaminophen (Paracetamol), Lornoxicam and Ibuprofen on cell viability as well as chondrogenic differentiation using a mouse embryonic ATDC5-cell-derived chondrocyte model.
METHODS: ATDC5 cells were treated with different concentrations of the NSAIDs. The viablility was evaluated by MTT assay while q-PCR analyses of gene expression of chondrogenic markers (Aggrecan, SOX-9, COL1 and COL2) on 5th & 10th day. Early glycosaminoglycan changes in articular cartilage were determined by safranin-O staining.
RESULTS: No clinical relevant concentration of Lornoxicam, Dexketoprofen and Ibuprofen proved beneficial influence on cell survival. Dexketoprofen and Lornoxicam promoted chondrogenesis through a significant increase of the Aggrecan and COL2 gene expression(levels) when compared to control samples. Histological staining further revealed that Lornoxicam and Dexketoprofen significantly increased glycosaminoglycan content, suggestive of enhanced chondrogenic differentiation.
CONCLUSION: Of all investigated NSAIDs, lornoxicam performed best in terms of chondrogenic differentiation and appears as the most suited for therapeutic approaches targeting cartilage repair / regeneration. These results are further improved with ITS supplementation, indicating a potential synergistic effect to improve cartilage tissue engineering.
Keywords: NSAIDs, chondrogenic differentiation, Lornoxicam and Dexketoprofe
Independent Analysis of Clinical Trial Data: GS1 Continuous Glucose Monitoring System (CGMS) in Pediatric Diabetes Management
No full textBackground: Diabetes mellitus poses significant challenges in pediatric populations, necessitating advanced glycemic monitoring technologies. This study presents an independent analysis of the GS1 Continuous Glucose Monitoring System (CGMS), originally developed by Shenzhen SiSensing Co., Ltd., and provided by its Turkish partner, BMED Pharmaceuticals. The analysis evaluates the efficacy, safety, and usability of the GS1 CGMS in pediatric patients aged 3 to under 18 years with diabetes mellitus.
Methods: This multicenter, prospective trial included 81 pediatric participants across three clinical centers in China: Beijing Children’s Hospital, Capital Medical University (Center 01); Shenzhen Children’s Hospital (Center 02); and Fujian Medical University Union Hospital (Center 03). Participants underwent 14 days of CGMS monitoring, with venous blood glucose measurements as reference. Key metrics included concordance rates within the 20/20% error range, Clarke and Consensus Error Grid analyses, and Mean Absolute Relative Difference (MARD%). Safety and usability were assessed through adverse event monitoring and participant feedback.
Results: A total of 79 participants completed the trial, achieving a 97.5% completion rate. Concordance rates were 93.9% across all glycemic ranges, surpassing predefined thresholds. Sensitivity and specificity for hypoglycemia detection were 97.6% and 87.3%, respectively, while hyperglycemia detection achieved 89.8% sensitivity and 97.0% specificity. The MARD% was 8.7%, consistently below the target of 18%. Usability scores averaged 95.3 ± 7.59, reflecting high satisfaction. Device-related adverse events, such as mild skin irritation, were self-limiting, and no serious adverse events were reported.
Conclusion: This independent analysis demonstrated that the GS1 CGMS offers high accuracy, safety, and usability in pediatric glycemic monitoring. These findings support its broader application in routine pediatric diabetes care. Future studies should explore long-term efficacy and comparative evaluations with other CGMS technologies.
Keywords Independent analysis, Continuous Glucose Monitoring (CGM), GS1 CGMS, Pediatric diabetes patient
Naproxen Sodium: The Superior Choice Over Dexketoprofen for Dental Pain and Inflammation Management
Full text linkThe management of postoperative pain and inflammation following dental procedures, such as dental implants and root canal therapies, is essential to ensure patient comfort and optimal recovery. Nonsteroidal anti-inflammatory drugs (NSAIDs) like Naproxen Sodium and Dexketoprofen are widely utilized due to their effectiveness in controlling pain and inflammation by inhibiting cyclooxygenase (COX) enzymes. This review compares the pharmacological characteristics, onset of action, duration of analgesic effects, and safety profiles of Naproxen Sodium and Dexketoprofen in managing pain associated with dental treatments. Naproxen Sodium’s rapid onset of action (within 15 minutes) and prolonged duration (up to 13 hours) make it a superior choice for postoperative pain control, minimizing the need for frequent dosing. Dexketoprofen, while providing pain relief within 30 minutes, has a shorter duration of effect, requiring more frequent administration. Naproxen Sodium also demonstrates superior anti-inflammatory properties and safety profile make it the preferred first-line option over Dexketoprofen for managing pain and inflammation following dental procedures as evidenced by FDA recommendations. The review concludes that Naproxen Sodium offers a more balanced efficacy, safety, and sustained analgesia, making it a preferred NSAID for managing postoperative dental pain and inflammation over Dexketoprofen.
Keywords: Naproxen Sodium, Dexketoprofen, Dental Pain, cyclooxygenase (COX) enzyme
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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