7,837 research outputs found
1,3-Bis(2,6-diisopropyl-phen-yl)-1H-imidazol-3-ium chloride dichloromethane disolvate
No full textIn the title compound, C27H37N2 +·Cl−·2CH2Cl2, the cation and the anion are each located on a crystallographic mirror plane. Both of the dichloromethane solvent molecules show a disorder across a mirror plane over two equally occupied positions. Additionally, one isopropyl group is also disordered. In the crystal, the cations are connected to the chloride ions via C—H[cdots, three dots, centered]Cl hydrogen bonds
Anthropogenic and Natural Perturbations of the Carbon Cycle
No full textA summary is given of recent results and unsolved problems regarding the carbon cycle. There is a lack of knowledge concerning the amounts of CO2 released by deforestation and land use, the response of terrestrial vegetation to increasing CO2, gas exchange air-sea and the water exchange between surface and deep ocean. Analyses of polar ice cores have demonstrated that atmospheric CO2 was lower during glacial than during interglacial times. These natural variations must be due to a change in operation of the oceans, but the precise mechanism is not yet known. Specific recommendations for experimental and modelling research regarding the global carbon cycle are given
Diminished TCR signaling in cutaneous T-cell Iymphoma is associated with decreased activities of Zap70, Syk and membrane-associated Csk
No full textMalignant cells of patients with cutaneous T cell lymphoma (CTCL) are of monoclonal origin and of the CD4+/CD45RO+ subset. Since unlike their normal counterparts, triggering of their TCR/CD3 in vitro elicits only a weak mitogenic response, we set out to determine which of the signal transduction molecules initiated by anti-CD3ε antibodies are affected in neoplastic cells. The results obtained from analysis of tumor cells from four patients show a general reduction in basal and induced tyrosine phosphorylation of a wide range of signaling proteins. Furthermore, the function of members from distinct families of protein tyrosine kinases was altered in neoplastic cells. The enzymatic activity of the membrane-bound fraction of Csk was suppressed, and its association with other cellular proteins was altered. There was a decline in the amount and activity of Syk, and a slight decrease in the specific activity of Lck kinases. Zap70 tyrosyl phosphorylation was reduced or undetectable and the kinase associated weakly, or not at all, with the TCR ζ chain. We propose that dampened TCR-triggered responses in CTCL are caused by suppression of an array of effector molecules required for coupling cell surface receptors to early and late signaling events
Open access self-archiving: An author study
No full textThis, our second author international, cross-disciplinary study on open access had 1296 respondents. Its focus was on self-archiving. Almost half (49%) of the respondent population have self-archived at least one article during the last three years. Use of institutional repositories for this purpose has doubled and usage has increased by almost 60% for subject-based repositories. Self-archiving activity is greatest amongst those who publish the largest number of papers. There is still a substantial proportion of authors unaware of the possibility of providing open access to their work by self-archiving. Of the authors who have not yet self-archived any articles, 71% remain unaware of the option. With 49% of the author population having self-archived in some way, this means that 36% of the total author population (71% of the remaining 51%), has not yet been appraised of this way of providing open access. Authors have frequently expressed reluctance to self-archive because of the perceived time required and possible technical difficulties in carrying out this activity, yet findings here show that only 20% of authors found some degree of difficulty with the first act of depositing an article in a repository, and that this dropped to 9% for subsequent deposits. Another author worry is about infringing agreed copyright agreements with publishers, yet only 10% of authors currently know of the SHERPA/RoMEO list of publisher permissions policies with respect to self-archiving, where clear guidance as to what a publisher permits is provided. Where it is not known if permission is required, however, authors are not seeking it and are self-archiving without it. Communicating their results to peers remains the primary reason for scholars publishing their work; in other words,
researchers publish to have an impact on their field. The vast majority of authors (81%) would willingly comply with a mandate from their employer or research funder to deposit copies of their articles in an institutional or subject-based repository. A further 13% would comply reluctantly; 5% would not comply with such a mandate
Estrategias para la obtención de estatus en contextos de pares de adolescentes tempranos
No full textDescargue el texto completo en el repositorio institucional de la Pontificia Universidad Católica de Chile: https://repositorio.uc.cl/handle/11534/36923Un porcentaje de fuerte evidencia ha demostrado que los estatus sociales prominentes y dominantes
están asociados a conductas agresivas. Además, algunas de estas perspectivas sugieren que la
combinación de conductas agresivas con estrategias prosociales podría ser más efectivas para
obtener estatus sociales altos. Sin embargo, las metodologías usadas para investigar este fenómeno
aún dejan algunas preguntas empíricas que son importantes de revisar. Se diseñaron tres estudios.
El primer estudio recolectó una muestra de 180 estudiantes de 5to a 8vo básico para validar y
adaptar el instrumento utilizado en los estudios posteriores. El segundo estudio recolectó una
muestra de 630 estudiantes de 5to a 8vo básico para identificar los perfiles de estrategias de control
de recursos y comparar sus niveles de agresión, conducta prosocial, popularidad y preferencia
social. El tercer estudio usó una muestra secundaria de un estudio longitudinal con 1163
estudiantes de 4to a 6to grado para identificar el rol de la conducta agresiva y prosocial en la
transición entre perfiles de estatus social. En general las conductas agresivas estuvieron asociadas a
estatus prominentes y a bajos niveles de estatus. La conducta prosocial no estuvo asociada con las
estrategias prosociales; sin embargo, ambas protegen a los individuos de perder estatus social. Esta
tesis muestra la importancia de tomar perspectivas metodológicas centradas en la persona para
estudiar la complejidad del fenómeno de contexto de pares.The present thesis aimed to describe the motivational,
behavioral and social status implications of the use of resource control strategies for
early adolescents. Three studies were designed to address this objective. The first study
collected a sample of 180 students from 5th to 8th grade to validate and adapt the
instruments used in the following studies. The second study collected a sample of 630
students from 5th to 8th grade to identify resource control strategies profiles and to
compare their levels of aggression, prosocial behavior, popularity and social preference.
The third study used a secondary sample from a larger longitudinal study of 1163
students from 4th to 6th grade to identify social status profiles and the role of aggression
and prosocial behavior in transitions between profiles. Results indicated that 3 profiles
of resource control strategies could be identified: Bistrategic, Prosocial and Noncontrollers.
Similar results could be seen in the social status profiles: High-Status,
Prominent Status, Average Status, Low Status. In general, aggressive behaviors were
associated with prominent positions as well to low status positions. Prosocial behaviors
were not associated with prosocial strategies, however both of them protected
individuals for falling into low status profiles. The thesis showed the importance of taking
person centered perspective to study the complexity of peer contextual phenomenon.Chile. Comisión Nacional de Investigación Científica y Tecnológica (Conicyt
MD simulation trajectory of a POPC/POPS (4:1) bilayer with 1M KCl, Berger force field for lipids, Dang's for K+ and ffgmx for Cl-
No full text<p>MD simulation trajectory of a POPC/POPS (4:1) bilayer with 1M KCl (102 POPC, 26 POPS, 4290 WAT, 106 K+, 80 Cl-). Additional K+ cations added to neutralize the negative charge of POPS. Berger force field for lipids, Dang's for K+ (), ffgmx for Cl- are employed. Gromacs 4.0.7, T=310K, 200 ns trajectories were calculated with the last 50 ns stored here).K+ nonbonding parameters (from Dang's JPC B 1999, 103, 8195 based on Vacha et al. Biophys. J 2009, 96, 4493.):<br>
sig=0.3048655 eps=0.418400</p>
<p>Used in:</p>
<p>P. Jurkiewicz, L. Cwiklik, A. Vojtiskova, P. Jungwirth, M. Hof, Structure, Dynamics, and Hydration of POPC/POPS Bilayers Suspended in NaCl, KCl, and CsCl <br>
<em>BBA Biomembranes </em>2012<em>, 1818, 609-616.</em><br>
DOI: 10.1016/j.bbamem.2011.11.033</p>
MD simulation trajectory of a POPC/POPS (4:1) bilayer with 1M CsCl, Berger force field for lipids, Dang's for Cs+ and ffgmx for Cl-
No full text<p>MD simulation trajectory of a POPC/POPS (4:1) bilayer with 1M CsCl (102 POPC, 26 POPS, 4290 WAT, 106 Cs+, 80 Cl-). Additional Cs+ cations added to neutralize the negative charge of POPS. Berger force field for lipids, Dang's for Cs+ (), ffgmx for Cl- are employed. Gromacs 4.0.7, T=310K, 200 ns trajectories were calculated with the last 50 ns stored here).<br>
K+ nonbonding parameters (from Dang's Cs+ from JPC B 1999, 103, 8195):<br>
sig=0.383086, eps=0.41840</p>
<p>Used in:</p>
<p>P. Jurkiewicz, L. Cwiklik, A. Vojtiskova, P. Jungwirth, M. Hof, Structure, Dynamics, and Hydration of POPC/POPS Bilayers Suspended in NaCl, KCl, and CsCl <br>
<em>BBA Biomembranes </em>2012<em>, 1818, 609-616.</em><br>
DOI: 10.1016/j.bbamem.2011.11.033</p>
Progress of international hydrogen production network for the thermochemical Cu–Cl cycle
No full textThis paper presents recent advances by an international team which is developing the thermochemical copper–chlorine (Cu–Cl) cycle for hydrogen production. Development of the Cu–Cl cycle has been pursued by several countries within the framework of the Generation IV International Forum (GIF) for hydrogen production with the next generation of nuclear reactors. Due to its lower temperature requirements in comparison with other thermochemical cycles, the Cu–Cl cycle is particularly well matched with Canada's Generation IV reactor, SCWR (Super-Critical Water Reactor), as well as other heat sources such as solar energy or industrial waste heat. In this paper, recent developments of the Cu–Cl cycle are presented, specifically involving unit operation experiments, corrosion resistant materials and system integration.Atomic Energy of Canada LimitedOntario Research Excellence FundNatural Sciences and Engineering Research Council of CanadaUniversity Network of Excellence in Nuclear Engineering (UNENE)Canada Research Chairs progra
ŻYCIE UKRYTE W SŁOWIE. "BEKSIŃSCY. PORTRET PODWÓJNY" MAGDALENY GRZEBIAŁKOWSKIEJ W ŚWIETLE POSTSTRUKTURALIZMU
No full textLife Hidden in Words. Magdalena Grzebiałkowska\u27s "Beksińscy. Portret podwójny" and Poststructuralism
The article analyzes Magdalena Grzebiałkowska\u27s biographical "Beksińscy. Portret podwójny" which focuses on the lives of Zdzisław Beksiński and Tomasz Beksiński. The author looks at the construction of the biography and its relationship to poststructuralism, which allows for an appreciation of the literary features of the book. He points to how the specificity of the content, language, a mode of narration in Grzebiałkowska\u27s book make it a full-fledged literary work itself. As such the book departs from a typical biographical scheme. Juxtaposing the book with poststructural ideas leads to the reconsideration of the role of the author in the process of shaping of a biographical narrative
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