1,720,954 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The importance of the immunoproteasome in the treatment of thymic epithelial tumors
No full textEpitheliale Thymustumoren sind seltene neoplastische Erkrankungen des Thymus und werden anhand ihrer histopathologischen Eigenschaften in Thymome und Thymuskarzinome unterteilt. Therapeutisch stellt die chirurgische Tumorresektion die erste Wahl dar und kann durch eine Radiotherapie sowie konventionelle Chemotherapeutika ergänzt werden. Rezidive treten häufig auf, doch aufgrund der geringen Mutationslast dieser Tumoren konnten bisher nur wenige molekulare Targets für eine zielgerichtete Zweitlinienbehandlung identifiziert werden. Aktuelle Beobachtungen weisen auf einen relevanten Zusammenhang zwischen dem Metabolismus epithelialer Thymustumoren und der Aktivität des Ubiquitin-Proteasom-Systems hin. Basierend auf der molekularen Zusammensetzung der katalytischen Untereinheiten werden verschiedene Proteasom-Subtypen unterschieden, wobei das Immunoproteasom (IP) in den Fokus dieser Arbeit geriet. Anhand von Frischgewebsproben und Zellkulturen wurde untersucht, inwiefern das IP in epithelialen Thymustumoren therapeutisch genutzt werden kann. Immunhistochemische Färbungen sowie die Auswertung genomischer Datensätze bestätigten, dass epitheliale Thymustumoren zusätzlich zum konstitutiven Proteasom auch das IP exprimieren. Proteinchemischen Analysen zufolge scheinen dabei insbesondere Thymuskarzinome ein hohes IP-Expressionsniveau aufzuweisen und sich diesbezüglich von Tumoren anderer Entitäten abzugrenzen. Eine spezifische Inhibition des IPs durch ONX-0914 oder KZR-504 zeigte im Zellkulturmodell keine effektive Viabilitätsminderung, während Carfilzomib als nicht-selektiver Proteasominhibitor in beiden untersuchten Thymuskarzinom-Zelllinien eine gute antitumorale Wirkung erzielte. Knockdowns der einzelnen katalytischen Untereinheiten des IPs wiesen nach, dass eine starke IP-Expression mit einem signifikant verbesserten Ansprechen von Thymuskarzinomzellen auf eine Carfilzomib-Behandlung einhergeht. Indem Korrelationsanalysen zwischen den IP-Expressionsniveaus verschiedener Tumorentitäten und den zugehörigen IC50-Werten für Carfilzomib durchgeführt wurden, konnte insbesondere für die β5i-Untereinheit des IPs auch entitätsübergreifend eine expressionsabhängige Vulnerabilität der Zellen gegenüber Carfilzomib bestätigt werden. Zusammenfassend verdeutlichen die Ergebnisse dieser Arbeit somit das therapeutische Potenzial einer Behandlung epithelialer Thymusneoplasien mit Carfilzomib in Abhängigkeit vom spezifischen IP-Expressionsniveau des Tumors.Thymic epithelial tumors are rare neoplastic diseases of the thymus and are divided into thymomas and thymic carcinomas based on their histopathological characteristics. Surgical tumor resection is the first choice of treatment and can be supplemented by radiotherapy and conventional chemotherapy. Recurrences occur frequently, but due to the low mutational burden of these tumors, only a few molecular targets for targeted second-line treatment have been identified to date. Current observations indicate a relevant connection between the metabolism of thymic epithelial tumors and the activity of the ubiquitin-proteasome system. Based on the molecular composition of the catalytic subunits, different proteasome subtypes are distinguished, with the immunoproteasome (IP) becoming the focus of this work. Fresh tissue samples and cell cultures were used to investigate how the IP can be used therapeutically in thymic epithelial tumors. Immunohistochemical staining and the evaluation of genomic data sets confirmed that thymic epithelial tumors express the IP in addition to the constitutive proteasome. According to protein chemical analyses, thymic carcinomas in particular appear to have a high level of IP expression and are therefore different from tumors of other entities. Specific inhibition of the IP by ONX-0914 or KZR-504 did not show any effective reduction in viability in the cell culture model, while carfilzomib, as a non-selective proteasome inhibitor, achieved a good antitumor effect in both thymic carcinoma cell lines examined. Knockdowns of the individual catalytic subunits of the IP demonstrated that strong IP expression is associated with a significantly improved response of thymic carcinoma cells to carfilzomib treatment. By performing correlation analyses between the IP expression levels of different tumor entities and the corresponding IC50 values for carfilzomib, an expression-dependent vulnerability of the cells to carfilzomib could be confirmed across entities, particularly for the β5i subunit of the IP. In summary, the results of this study illustrate the therapeutic potential of treating thymic epithelial neoplasms with carfilzomib depending on the specific IP expression level of the tumor.10000-01-01Diese Dateien sind bis zum Abschluß der Staatsexamensprüfung gesperrt.These files are not accessible until the state exam has been completed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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