268 research outputs found
Fig 2 in Evolutionary relationships of Macaca fascicularis fascicularis (Raffles 1821) (Primates: Cercopithecidae) from Singapore revealed by Bayesian analysis of mitochondrial DNA sequences
No full textFig 2. Map of central Singapore showing the sampling locations in the Bukit Timah (BTNR) and Central Catchment (CCNR) Nature Reserves. Map created using ArcGIS® (ESRI® 2015).Published as part of Schillaci, Michael A., Klegarth, Amy R., Switzer, William M., Shattuck, Milena R., Lee, Benjamin P. Y-H. & Hollocher, Hope, 2017, Evolutionary relationships of Macaca fascicularis fascicularis (Raffles 1821) (Primates: Cercopithecidae) from Singapore revealed by Bayesian analysis of mitochondrial DNA sequences, pp. 3-19 in Raffles Bulletin of Zoology 65 on page 9, DOI: 10.5281/zenodo.535578
sj-docx-1-hol-10.1177_09596836221131696 – Supplemental material for A 5000-year record of relative sea-level change in New Jersey, USA
No full textSupplemental material, sj-docx-1-hol-10.1177_09596836221131696 for A 5000-year record of relative sea-level change in New Jersey, USA by Jennifer S Walker, Tanghua Li, Timothy A Shaw, Niamh Cahill, Donald C Barber, Matthew J Brain, Robert E Kopp, Adam D Switzer and Benjamin P Horton in The Holocene</p
Fig 3 in Evolutionary relationships of Macaca fascicularis fascicularis (Raffles 1821) (Primates: Cercopithecidae) from Singapore revealed by Bayesian analysis of mitochondrial DNA sequences
No full textFig 3. Phylogenetic tree topology from Bayesian inference of 12S/tRNA-val/16S mtDNA sequences using a Birth-Death speciation tree prior, and HYK+G+I nucleotide substitution model in BEAST v2.1.3. Lettered identifications for clades are presented below the branches at major nodes. Posterior probabilities are displayed above the branches at nodes. Numbers in parentheses appearing with haplotype identifications are presented in Table 1, and correspond to numbered locations presented on the Figure 1 map. The Singapore haplotypes form two phylogenetic subgroupings, one from the Bukit Timah Nature Reserve (Sing1) and the other from the Central Catchment Nature Reserve (Sing2 & Sing3).Published as part of Schillaci, Michael A., Klegarth, Amy R., Switzer, William M., Shattuck, Milena R., Lee, Benjamin P. Y-H. & Hollocher, Hope, 2017, Evolutionary relationships of Macaca fascicularis fascicularis (Raffles 1821) (Primates: Cercopithecidae) from Singapore revealed by Bayesian analysis of mitochondrial DNA sequences, pp. 3-19 in Raffles Bulletin of Zoology 65 on page 11, DOI: 10.5281/zenodo.535578
Toga Day at Southeast High School 1978
No full textToga Day at Southeast High School 1978. From left to right: Patty Honnegar, Greg Hollister, Tom Tucker, Tina Switzer, and Coach Benjamin Buzz Narbut
Studies on the regulation in vivo and structure/function relationships of the enzyme 5-phosphoribosyl-alpha-1-pyrophosphate synthetase from Salmonella typhimurium
No full textLittle is known about the amino acids present in the active site of the enzyme phosphoribosylpyrophosphate (PRPP) synthetase or the regulation of the structural gene (prs) in vivo. Site directed mutagenesis and characterization of mutant proteins were used to examine possible residues involved in catalysis. Initial studies of the transcriptional regulation of the prs gene were also conducted.The Salmonella typhimurium prsB mutant was reported to produce undetectable levels of PRPP synthetase activity (Pandey, N. K., and R. L. Switzer, J. Gen. Microbiol. 128: 1863-1871, 1982). It was shown that prsB was an allele of the prs gene, therefore it was renamed prs-100. The prs-100 mutation was the replacement of Arg-78 by Cys. The mutant PRPP synthetase was purified and determined to possess elevated Michaelis constants, a reduced maximal velocity (30% of wild type) and reduced sensitivity to the allosteric inhibition. It appears that the mutation alters the enzyme's kinetic properties through substantial structural alterations.Histidine 130 (His130) was proposed to have a role in divalent cation binding (Bower et al., J. Biol. Chem. 264: 10287-10291, 1989). To investigate this, His130 was replaced by glutamine, tyrosine, asparagine and aspartate by site directed mutagenesis. The mutant proteins were over-produced, purified and characterized. The mutant enzymes had altered Michaelis constants and maximal velocities. It was demonstrated that His130 was not involved in divalent cation binding, but was crucial for catalysis.The prs leader is 417 bp in S. typhimurium. The region between the prs coding region and an upstream gene (hemA) in S. typhimurium was cloned and sequenced. This region was shown to encode two ORFs of unknown function, which were transcribed in the same direction as the prs gene. Northern blots showed that the prs message is transcribed from two promoters, the first promoter (P\sb1) originating upstream of ORF 1, and expressing the prs gene in a tricistronic operon and a second promoter (P\sb2), located within the ORF 2 coding frame, which transcribes the prs gene only.Made available in DSpace on 2011-05-07T12:54:56Z (GMT). No. of bitstreams: 2
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Estimating excess hazard ratios and net survival when covariate data are missing: strategies for multiple imputation.
No full textBACKGROUND: Net survival is the survival probability we would observe if the disease under study were the only cause of death. When estimated from routinely collected population-based cancer registry data, this indicator is a key metric for cancer control. Unfortunately, such data typically contain a non-negligible proportion of missing values on important prognostic factors (eg, tumor stage). METHODS: We carried out an empirical study to compare the performance of complete records analysis and several multiple imputation strategies when net survival is estimated via a flexible parametric proportional hazards model that includes stage, a partially observed categorical covariate. Starting from fully observed cancer registry data, we induced missingness on stage under three scenarios. For each of these scenarios, we simulated 100 incomplete datasets and evaluated the performance of the different strategies. RESULTS: Ordinal logistic models are not suitable for the imputation of tumor stage. Complete records analysis may lead to grossly misleading estimates of net survival, even when the missing data mechanism is conditionally independent of survival time given the covariates and the bias on the excess hazard ratios estimates is negligible. CONCLUSIONS: As key covariates are unlikely missing completely at random, studies estimating net survival should not use complete records. When the missingness can be inferred from available data, appropriate multiple imputation should be performed. In the context of flexible parametric proportional hazards models with a partially observed stage covariate, a multinomial logistic imputation model for stage should be used and should include the Nelson-Aalen cumulative hazard estimate and the event indicator
The relationship between quality of research and citation frequency.
No full textBACKGROUND: Citation counts are often regarded as a measure of the utilization and contribution of published articles. The objective of this study is to assess whether statistical reporting and statistical errors in the analysis of the primary outcome are associated with the number of citations received. METHODS: We evaluated all original research articles published in 1996 in four psychiatric journals. The statistical and reporting quality of each paper was assessed and the number of citations received up to 2005 was obtained from the Web of Science database. We then examined whether the number of citations was associated with the quality of the statistical analysis and reporting. RESULTS: A total of 448 research papers were included in the citation analysis. Unclear or inadequate reporting of the research question and primary outcome were not statistically significantly associated with the citation counts. After adjusting for journal, extended description of statistical procedures had a positive effect on the number of citations received. Inappropriate statistical analysis did not affect the number of citations received. Adequate reporting of the primary research question, statistical methods and primary findings were all associated with the journal visibility and prestige. CONCLUSION: In this cohort of published research, measures of reporting quality and appropriate statistical analysis were not associated with the number of citations. The journal in which a study is published appears to be as important as the statistical reporting quality in ensuring dissemination of published medical science
McMillan Mesa Village specific plan
No full textabstract: A plan for the development of the McMillan Mesa Village, a 146 acre site on Switzer Mesa in Flagstaff, Arizon
Evidence Summary: The Launch of a Joint Library/Writing Centre Online Course on Academic Integrity
No full textA Review of:
Greer, K., Swanberg, S., Hristova, M., Switzer, A. T., Daniel, D., & Perdue, S. W. (2012). Beyond the web tutorial: Development and implementation of an online, self-directed academic integrity course at Oakland University. The Journal of Academic Librarianship, 38(5), 251-258. doi: 10.1016/j.acalib.2012.06.01
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