196,926 research outputs found
The class of (n,m)power-A-quasi-hyponormal operators in semi-Hilbertian space
No full textThe concept of K-quasi-hyponormal operators on semi-Hilbertian space is defined by Ould Ahmed Mahmoud Sid Ahmed and Abdelkader Benali in [7]. This paper is devoted to the study of new class of operators on semi-Hilbertian space H, ∥. ∥Acalled (n,m)power-A-quasi-hyponormal denoted [(n,m)QH]A.We give some basic properties of these operators and some examples are also given .An operator T ∈ BA(H) is said to be (n,m) power-A-quasi-hyponormal for some positive operator A and for some positive integers n and m if T⋕((T⋕)mTn— Tn(T⋕)m)T≥A or equivalently AT⋕((T⋕)mTn— Tn(T⋕)m)T≥
The progression of the tubulointerstitial damage in canine renal diseases
No full textKidney lesions can primarily involve the glomeruli, tubulointerstitium, or renal vessels. However, regardless of the initiating site of injury, all compartments often eventually become affected. Tubulointerstitial damage (TID) plays a central role in the progression of renal diseases, leading to an irreversible decline in renal function and ultimately resulting in end-stage renal disease (ESRD). TID is characterized by loss of renal tubules, increased number of interstitial myofibroblasts, and accumulation of extracellular matrix (ECM) in the interstitium usually with chronic inflammatory cell infiltrate.
This project aimed at investigating different aspects of the progression of chronic TID in canine renal diseases.
The first part of the project consisted in a morphological study describing the progression of renal lesions in canine Leishmaniosis possibly representing a model of TID progression in infectious immune-mediated glomerulonephritis. Renal biopsies taken at the beginning and after a 60-day period specific leishmanicidal treatment were evaluated. Progression of the TID was overall mild but present in half of the dogs especially those that had severe TID already at the first biopsy. The results further confirmed that the progression of the chronic TID is independent from the persistence of the causative agent. Moreover, elimination of the etiological agent, by means of the leishmanicidal treatment is not responsible for a significant improvement of renal lesions when these are severe and include irreversible changes like the presence of obsolescent glomeruli andd fibrosis. In contrast the positive effect of the treatment seems to occur in case of mild TID and is possibly related to the reduction of the inflammatory component.
The second part of the project focused on the role of tubular epithelial cells (TECs) in the progression of chronic TID. Morphological diagnosis, severity of inflammation, interstitial fibrosis, HLA-DR expression by TECs and clinicopathological variables were compared in renal biopsies from dogs with spontaneous kidney diseases of varying severities and etiologies. Fibrosis, HLA-DR expression, serum creatinine concentration (SCr), and urine protein-to-creatinine ratio (UPC) were all increased in dogs with primary glomerular disease compared with dogs with acute tubular necrosis. HLA-DR expression by TECs was positively correlated to fibrosis, inflammation, UPC, and SCr. The study provided evidence of the capacity of TECs of acting as non-professional antigen presenting cells (APCs) in chronic TID, identifying a potential causative effect of the proteinuria. Moreover, this expression of TECs seems to precede and partially overlap with the process of epithelial-to-mesenchymal transition (EMT) and potentially represents a phase of the EMT process itself.
The last part of the project investigated and described the progression of TID in a canine model of CKD and was conducted in partnership with the Texas A&M University (College Station, TX, USA). The included dogs were members of a single family affected by a X-linked hereditary nephropathy (XLHN) caused by a mutation in the gene encoding the α5 chain of type IV collagen, which is a crucial component of normal glomerular basement membranes (GBM). The salient clinical and pathological features of the nephropathy that occurs in male dogs with XLHN include juvenile onset of proteinuria and renal failure rapidly progressive to ESRD. Aims of the study were to examine the evolution of renal injury and the expression of selected molecules potentially involved in the progression of chronic TID. Affected dogs were characterized by progressive loss of glomeruli mostly undergoing cystic glomerular atrophy and less commonly global glomerulosclerosis. Primary lesions into the glomerulus were mesangial matrix expansion and hypercellularity. The tubulointerstitial lesions included changes typical of chronic TID, like tubular necrosis and atrophy, interstitial fibrosis and inflammation. The obtained results suggested that two different phases of the disease can be identified. The first was classified as an “early” phase (4 months of age), characterized by minimal or absence of histopathological lesions but evident proteinuria that is characterized by TGFβ, CTGF, and PDGFRα overexpression, likely produced by podocytes and TECs in response to the glomerular damage and intratubular proteinuria. The second “advanced” phase (after 6 months of age) was characterized by prominent glomerular and tubulointerstitial changes associated with an upregulation of clusterin and TIMP1 by TECs.
The obtained results significantly improved the understanding of the progression of chronic TID in canine renal diseases pointing out the importance of proteinuria and possibly other molecular changes that precede the morphological changes. More data are needed to further understand the mechanisms responsible for the initiation ad promotion of the secondary TID and the major cellular and molecular players involved in order to identify early and specific markers of renal damage, improve the time of the diagnosis and eventually new targets for therapy
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Dr. Glendon Swarthout
No full textHosted by Roger M. Busfield, MSU Assistant Professor of Speech and Theater, Meet the Author is designed to introduce a general audience to a contemporary author and their work through in-depth interviews. This episode features a conversation between Dr. Glendon Swarthout, prolific author and English professor at MSU, and assistant professors Sam S. Baskett and Theodore B. Strandness
DarSIA v1.0
No full textDarcy Scale Image Analysis Toolbox.
The toolbox allows to analyze pore space dynamics including flow, transport and deformation. The focus of the package is the Darcy scale. Thus, upscaling routines are a core of the release, involving the full chain of signal to data conversion. Deformations are studied by multiscale diffeoemrophic image registration.
An example use of DarSIA v1.0 is the image analysis of the International FluidFlower Benchmark Study Dataset (10.5281/zenodo.7510589). For the analysis see 10.5281/zenodo.7515038.
For a more detailed introduction, see: Nordbotten, J. M., Benali, B., Both, J. W., Brattekås, B., Storvik, E., & Fernø, M. A. (2023). DarSIA: An open-source Python toolbox for two-scale image processing of dynamics in porous media. arXiv preprint arXiv:2301.05455
Just in Time Transformers
No full textPrecise energy load forecasting in residential households is crucial for mitigating carbon emissions and enhancing energy efficiency; indeed, accurate forecasting enables utility companies and policymakers, who advocate sustainable energy practices, to optimize resource utilization. Moreover, smart meters provide valuable information by allowing for granular insights into consumption patterns. Building upon available smart meter data, our study aims to cluster consumers into distinct groups according to their energy usage behaviours, effectively capturing a diverse spectrum of consumption patterns. Next, we design JITtrans (Just In Time transformer), a novel transformer deep learning model that significantly improves energy consumption forecasting accuracy, with respect to traditional forecasting methods. Extensive experimental results validate our claims using proprietary smart meter data. Our findings highlight the potential of advanced predictive technologies to revolutionize energy management and advance sustainable power systems: the development of efficient and eco-friendly energy solutions critically depends on such technologies
Simulation of thermal plant optimization and hydraulic aspects of thermal distribution loops for large campuses
No full textFollowing an introduction, the author describes Texas A&M University and its utilities system. After that, the author presents how to construct simulation models for chilled water and heating hot water distribution systems. The simulation model was used in a $2.3 million Ross Street chilled water pipe replacement project at Texas A&M University. A second project conducted at the University of Texas at San Antonio was used as an example to demonstrate how to identify and design an optimal distribution system by using a simulation model. The author found that the minor losses of these closed loop thermal distribution systems are significantly higher than potable water distribution systems. In the second part of the report, the author presents the latest development of software called the Plant Optimization Program, which can simulate cogeneration plant operation, estimate its operation cost and provide optimized operation suggestions. The author also developed detailed simulation models for a gas turbine and heat recovery steam generator and identified significant potential savings. Finally, the author also used a steam turbine as an example to present a multi-regression method on constructing simulation models by using basic statistics and optimization algorithms. This report presents a survey of the author??s working experience at the Energy Systems Laboratory (ESL) at Texas A&M University during the period of January 2002 through March 2004. The purpose of the above work was to allow the author to become familiar with the practice of engineering. The result is that the author knows how to complete a project from start to finish and understands how both technical and nontechnical aspects of a project need to be considered in order to ensure a quality deliverable and bring a project to successful completion. This report concludes that the objectives of the internship were successfully accomplished and that the requirements for the degree of Degree of Engineering have been satisfied
Effet des paramètres thermodynamiques et opératoires sur la granulation humide à fort taux de cisaillement
No full textCette étude est consacrée à la granulation humide en discontinu des poudres pharmaceutiques par pulvérisation des solutions liantes dans un granulateur à fort taux de cisaillement. Ce travail a pour objectif de développer des méthodologies prédictives et des outils d’investigation permettant de mieux choisir les paramètres thermodynamiques locaux afin d’assurer des propriétés d’usage bien définies des produits finaux. Nous avons donc étudié l’influence de deux paramètres thermodynamiques : énergie de surface et paramètre de solubilité de couple liant/solide. La caractérisation des énergies de surface de couple liant/substrat a été effectuée par la détermination de l’angle de contact. La détermination des paramètres de solubilité ou de cohésion a été effectuée en utilisant la simulation par dynamique moléculaire. La comparaison entre l’approche prédictive des paramètres de solubilité basée sur la simulation moléculaire et celle des énergies de surface a montré que les deux approches fournissent des informations qualitatives identiques concernant les intensités et les modes des interactions entre les solides. En se basant sur les interactions substrat/liant, l'hydroxypropylméthylcellulose est considérée comme le meilleur liant à employer pour la granulation des particules de cellulose microcristalline
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