101,321 research outputs found
Evolution of ECG changes in Tako Tsubo Cardiomyopathy: Arrhythmias first, QT Prolongation later?
No full textConference abstracts published as Supplement: Heart, Lung and Circulation, 2010; 19 (Supp. 2):S104A. M. Kucia, C. Neil, T. Nguyen, J. Beltrame, M. Arstall and J. D. Horowitzhttp://www.csanz2010.com
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
The litospheric mantle beneath Central Mongolia: costraints from spinel-bearing peridotite xenoliths and high-pressure experiments
No full textThis study investigates the poorly understood lithospheric mantle of the Central Asian Orogenic Belt, focusing on spinel-bearing mantle xenoliths collected from volcanic structures in the Mandakh-Mandal-Gobi region of Central Mongolia. These xenoliths, primarily lherzolites with minor harzburgites and one pyroxenite, are hosted in alkaline lavas aged between 82.5 ± 2 Ma and 51 ± 2 Ma. The xenolith textures range from porphyroblastic to protogranular, with melt-crystal reaction features varying by sampling area. Major elements are relatively homogeneous within xenoliths, but Rare Earth Elements (REE) and other incompatible element patterns show significant heterogeneity, particularly in xenoliths from the last magmatic event, which reflect metasomatism and basalt extraction of an older and probably deeper Sub-Continental Lithospheric Mantle.
Given the challenges of accurately estimating formation depths for spinel peridotite xenoliths, we conducted high-pressure experiments at the Bayerisches Geoinstitut to simulate mantle conditions beneath the study area and refine thermobarometric methods. Experiments were performed with a piston cylinder press in a pressure-temperature (P-T) window of 5–25 kbar and 1000–1200°C, using synthetic oxides and powdered mineral compositions. The results helped to better evaluate the current geothermobarometric methods and to construct phase stability fields in pseudosections, revealing that samples from the latest magmatic event show higher equilibrium P-T conditions, consistent with observed mineral chemistry.
The combined natural and experimental data, provide insight into the geodynamic evolution of the region. Initial magmatism at the Mandal-Gobi volcano sampled a relatively homogeneous, depleted mantle, while subsequent events associated with graben formation at Log Uul introduced limited melt interaction. In contrast, the Rigo dyke samples reflect a deeper, different mantle portion enriched in light REE and depleted in heavy REE, indicative of significant prior melting events and metasomatism. This evolving sequence suggests mantle upwelling and sampling during lithospheric extension, contributing to a complex, heterogeneous mantle beneath Central Mongolia.This study investigates the poorly understood lithospheric mantle of the Central Asian Orogenic Belt, focusing on spinel-bearing mantle xenoliths collected from volcanic structures in the Mandakh-Mandal-Gobi region of Central Mongolia. These xenoliths, primarily lherzolites with minor harzburgites and one pyroxenite, are hosted in alkaline lavas aged between 82.5 ± 2 Ma and 51 ± 2 Ma. The xenolith textures range from porphyroblastic to protogranular, with melt-crystal reaction features varying by sampling area. Major elements are relatively homogeneous within xenoliths, but Rare Earth Elements (REE) and other incompatible element patterns show significant heterogeneity, particularly in xenoliths from the last magmatic event, which reflect metasomatism and basalt extraction of an older and probably deeper Sub-Continental Lithospheric Mantle.
Given the challenges of accurately estimating formation depths for spinel peridotite xenoliths, we conducted high-pressure experiments at the Bayerisches Geoinstitut to simulate mantle conditions beneath the study area and refine thermobarometric methods. Experiments were performed with a piston cylinder press in a pressure-temperature (P-T) window of 5–25 kbar and 1000–1200°C, using synthetic oxides and powdered mineral compositions. The results helped to better evaluate the current geothermobarometric methods and to construct phase stability fields in pseudosections, revealing that samples from the latest magmatic event show higher equilibrium P-T conditions, consistent with observed mineral chemistry.
The combined natural and experimental data, provide insight into the geodynamic evolution of the region. Initial magmatism at the Mandal-Gobi volcano sampled a relatively homogeneous, depleted mantle, while subsequent events associated with graben formation at Log Uul introduced limited melt interaction. In contrast, the Rigo dyke samples reflect a deeper, different mantle portion enriched in light REE and depleted in heavy REE, indicative of significant prior melting events and metasomatism. This evolving sequence suggests mantle upwelling and sampling during lithospheric extension, contributing to a complex, heterogeneous mantle beneath Central Mongolia
Black esophagus in forensic autopsies: impressive finding and cause of death?
No full textBlack esophagus (BE) is characterized by a discoloration of the esophageal mucosa, commonly arising from acute esophageal necrosis. The underlying pathogenesis of BE is poorly understood though it is frequently associated with comorbidities, such as diabetes mellitus, alcohol abuse, infections. Determining the cause of death in cases involving BE at autopsy can be particularly challenging. The report presents the case of a 45-year-old man with a history of alcohol abuse. Autopsy revealed extensive BE along with bilateral pneumonia. Cause of death was determined to be severe pneumonia in combination with acute esophageal necrosis, against a background of chronic alcohol abuse. This case underscores the importance of a thorough forensic investigation, including anamnestic information, autopsy findings and histopathological examination, in order to accurately establish the cause of death, even in presence of dramatic findings such as BE
Hmg4, a new member of the Hmg1/2 gene family
No full textHigh mobility group (HMG) proteins are abundant components of mammalian nuclei and fall into three families. The members of one such family, HMG1 and HMG2, are ubiquitously expressed and facilitate the formation of nucleoprotein complexes where the DNA is sharply bent. We have identified a mouse cDNA that codes for a novel 200-amino-acid protein of the HMG1/2 family, which we called HMG4. The mouse Hmg4 gene is highly expressed in the embryo; Hmg4 transcripts are barely detectable in adult tissues. The human HMG4 gene, which is extremely similar to its mouse homolog, has been sequenced as part of chromosome X, band q28. HMG4, HMG1, and HMG2 proteins have been highly conserved during vertebrate evolution, suggesting that each has at least some unique property. It is possible that HMG4 is required during development
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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