120,119 research outputs found
Tébar Belmonte, L. (2003): El perfil del profesor mediador. Aula XXI, Santillana, Madrid
No full textReseña de la obra de Tébar Belmonte, L. "El perfil del profesor mediador"
Incidence of thrombotic complications in adult patients with acute lymphoblastic leukaemia receiving L-asparaginase during induction therapy: a retrospective study. The GIMEMA Group.
No full textThe incidence of thrombotic complications chronologically related to L-asparaginase administration is retrospectively analyzed in 238 adult ALL patients treated according to the GIMEMA protocol ALL 0288. The patients (126 males and 112 females, aged 12-68 years, median 29) received E. coli L-asparaginase (L-ase) in the induction phase at a dosage of 6000 U/m2/day x 7 d starting on d 15, as well as vincristine, prednisone, daunorubicin and cyclophosphamide, the last-named by random 1:1. Ten patients (4.2%) developed thrombotic complications 5-15 d (median 11 d) after the start of L-ase treatment. The thrombotic events, which were lethal in 5 patients, involved the cerebral sinus (5 cases), the cerebral arteria (2 cases), the portal vein (1 case), the pulmonary district (1 case), and a deep vein in the lower extremity (1 case). The occurrence of these complications was not related to the general thrombotic risk factors, nor to the main clinical and laboratory data registered at diagnosis and immediately before the start of L-asparaginase treatment. The present study documents for the first time in a sufficiently large series of adult ALL patients that the incidence and the severity of thrombotic events related to L-ase administration are relevant and need further consideration
Hypercoagulability during l‐asparaginase treatment: the effect of antithrombin III supplementation in vivo
No full textTo evaluate the occurrence of hypercoagulability during treatment with l‐asparaginase (l‐ase), thrombin‐antithrombin complex (TAT) and d‐dimer levels in plasma were serially measured in 15 consecutive adult patients with acute lymphoblastic leukaemia or lymphoblastic lymphoma who had recently completed a chemotherapy cycle with cytosine arabinoside and methotrexate. The first eight patients (group A) received i.v. l‐ase alone (20000 U/m2 on alternate days over 10 d); the last seven patients (group B) received, in addition to l‐ase, bolus injection of antithrombin concentrate (2000 U) on alternate days for a total of six administrations, beginning with the second l‐ase infusion. Increased levels of TAT (P<0·05) and d‐dimer (P<0·01) were observed prior to l‐ase, possibly related to inflammation and cytolysis secondary to previous chemotherapy. In patients treated with l‐ase alone, further elevation of TAT (P<0·05) and persistence of increased d‐dimer were observed, associated with marked reduction of the anticoagulant activities of protein C, protein S and antithrombin III. At variance, in patients receiving antithrombin III supplementation there was no increase of TAT and a normalization of d‐dimer levels occurred during l‐ase treatment. In these patients, mean plasma antithrombin III activity was maintained at levels higher than 70% of normal throughout the treatment. The rate of decline of fibrinogen, factor IX, protein C and protein S was unaffected by antithrombin III supplementation, indicating that hypercoagulability has little if any relevance for the reduction of coagulation factors and inhibitors induced by l‐ase treatment. The usefulness of antithrombin III concentrates in preventing thromboembolic complications in patients submitted to l‐ase treatment remains to be determined. Copyright © 1990, Wiley Blackwell. All rights reserve
Art contemporain et préservation critique des monuments du fascisme en Italie. Un 'iconoclash' à Bolzano
No full textL’ abitare dei Piceni: il caso di Belmonte Piceno (AP)
No full textIn 1910 Innocenzo Dall’Osso dug a very important settlement for the Piceno’s culture, Belmonte (Ascoli
Piceno, Marche). Unfortunately, the adverse events of the Archaeological Museum of Ancona caused the
destruction of most of the materials of this center, including those from the village. Only the recovery of
old pictures and drawings in the Archives of the ‘Soprintendenza archeologica delle Marche’ has allowed
to acquire more information about this excavation, which can now make us able to do some observations
in this regard and to compare the discovery of Belmonte with new evidences emerged in the Piceno area during recent decades, combined with brief descriptions provided by the same Dall’Oss
Introduction: Critical issues in the study of visual and material culture of Italian colonialism
No full textIn this special issue of Modern Italy, four early-career scholars examine how the study of objects and images rooted in Fascist imperialist history enables a sustained interrogation of Italy's colonial imaginary. Their articles explore the diverse possibilities offered by the study of visual and material culture for scholars of imperialism, as it is precisely this realm of visual and material culture that emerges as a site of negotiation in which different individuals and constituencies contended with the regime's ideology
A regimen for antithrombin III substitution in patients with acute lymphoblastic leukemia under treatment with L-asparaginase
No full textBackground and methods: Seventeen adult patients with acute lymphoblastic leukemia (ALL) treated with L-asparaginase (20,000 IU/m2 on six alternate days) were infused with antithrombin III (AT III) concentrates (Kybernin P, Behring). Substitution therapy was aimed at increasing the reduced AT III concentration usually found in these patients, since AT III deficiency is thought to be associated with an increased risk of thrombosis. Two schedules of AT III administration, different in dosage, timing and duration were evaluated. The first 7 patients (group A) received a fixed dose of 2,000 U every day for 6 times, starting with the second L-asparaginase (L-ase) infusion, independently of their plasma AT III levels. In the following 10 patients (group B), 20-25 U/Kg b.w. were administered daily for 7 times only when the plasma AT III level was lower than 60% with plasma fibrinogen higher than 100 mg/dl and platelet count higher than 50 x 10(9)/l, or when AT III was below 40%. Thirteen patients who received L-ase without AT III substitution served as controls.
Results and conclusions: Both substitution regimens resulted in mean plasma AT III nadir values significantly (p less than 00.1) higher than in the controls. Our data suggest that, in ALL patients receiving L-ase according to the L20 protocol, satisfactory plasma AT III levels may be assured with infusions of 20-25 U/Kg b.w./day for 7-10 days, starting by day 2 of L-ase treatment
Indagini briologiche in aree urbane: diversità briofitica dei centri abitati di Erice (Trapani) e Belmonte Mezzagno (Palermo).
No full textBryologic surveys in urban areas: bryophyte diversity of the population centers of Erice (province of Trapani)
and Belmonte Mezzagno ((province of Palermo). The bryophytic flora of the towns of Erice (Trapani) and Belmonte Mezzagno
(Palermo) have been studied. The first consists of 53 taxa (42 mosses and 11 liverwort), two of which are new for
the province of Trapani, the second of 40 taxa (38 mosses and 2 liverworts), one of which new for the province of Palermo.
A comparison between the studied bryofloras and those of other Sicilian urban areas shows that Erice’s bryophytic flora is,
given its size, rich in species and families
Correlation between membrane bending and lipidic composition during the sperm acrosomal exocytosis : computational analysis
No full textFil: Suhaiman, L..Fil: Borioni, J.L..Fil: Ferguson, M..Fil: Belmonte, S..Fil: Del Popolo, M. G.
STADI DI RESISTENZA DI ORGANISMI PLANCTONICI PRESENTI NEI SEDIMENTI DEL LAGO COSTIERO DI BUTRINTO (ALBANIA MERIDIONALE)
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