2,901 research outputs found
Author Co-Citation Analysis (ACA): a powerful tool for representing implicit knowledge of scholar knowledge workers
No full textIn the last decade, knowledge has emerged as one of the most important and valuable organizational assets. Gradually this importance caused to emergence of new discipline entitled ―knowledge management‖. However one of the major challenges of knowledge management is conversion implicit or tacit knowledge to explicit knowledge. Thus Making knowledge visible so that it can be better accessed, discussed, valued or generally managed is a long-standing objective in knowledge management. Accordingly in this paper author co- citation analysis (ACA) will be proposed as an efficient technique of knowledge visualization in academia (Scholar knowledge workers)
Analysis of MicroRNA Expression in Embryonic Developmental Toxicity Induced by MC-RR
No full textAs cynobacterial blooms frequently occur in fresh waters throughout the world, microcystins (MCs) have caused serious damage to both wildlife and human health. MCs are known to have developmental toxicity, however, the possible molecular mechanism is largely unknown. This is the first toxicological study to integrate post-transcriptomic, proteomic and bioinformatics analysis to explore molecular mechanisms for developmental toxicity of MCs in zebrafish. After being microinjected directly into embryos, MC-RR dose-dependently decreased survival rates and increased malformation rates of embryos, causing various embryo abnormalities including loss of vascular integrity and hemorrhage. Expressions of 31 microRNAs (miRNAs) and 78 proteins were significantly affected at 72 hours post-fertilisation (hpf). Expressions of miR-430 and miR-125 families were also significantly changed. The altered expressions of miR-31 and miR-126 were likely responsible for the loss of vascular integrity. MC-RR significantly reduced the expressions of a number of proteins involved in energy metabolism, cell division, protein synthesis, cytoskeleton maintenance, response to stress and DNA replication. Bioinformatics analysis shows that several aberrantly expressed miRNAs and proteins (involved in various molecular pathways) were predicted to be potential MC-responsive miRNA-target pairs, and that their aberrant expressions should be the possible molecular mechanisms for the various developmental defects caused by MC-RR
The proteomic study on cellular responses of the testes of zebrafish (Danio rerio) exposed to microcystin-RR
No full textMicrocystin-RR (MC-RR) is a commonly encountered cyanotoxin and receives increasing attention due to the risk of its bioaccumulation in aquatic animals like fish. This study investigated the protein profiles of zebrafish (Danio rerio) testes after intraperitoneal injection (i.p.) with 0.5 LD50 (2000 mu g/kg). MC-RR caused a noticeable damage to testicular ultrastructure, showing widened intercellular junction, distention of mitochondria. The testes showed a rapid response of its defense systems to the oxidative stress caused by MC-RR. This is the first to use a proteomic approach to obtain an overview of the effects of MC-RR on the testes of zebrafish. The proteomic results revealed that toxin exposure remarkably altered the abundance of 24 proteins that were involved in cytoskeleton assembly, oxidative stress, glycolysis metabolism, calcium ion binding and other biological functions. In conclusion, MC-RR damaged the testes and was toxic to the reproductive system of male zebrafish mainly through causing oxidative stress.Microcystin-RR (MC-RR) is a commonly encountered cyanotoxin and receives increasing attention due to the risk of its bioaccumulation in aquatic animals like fish. This study investigated the protein profiles of zebrafish (Danio rerio) testes after intraperitoneal injection (i.p.) with 0.5 LD50 (2000 mu g/kg). MC-RR caused a noticeable damage to testicular ultrastructure, showing widened intercellular junction, distention of mitochondria. The testes showed a rapid response of its defense systems to the oxidative stress caused by MC-RR. This is the first to use a proteomic approach to obtain an overview of the effects of MC-RR on the testes of zebrafish. The proteomic results revealed that toxin exposure remarkably altered the abundance of 24 proteins that were involved in cytoskeleton assembly, oxidative stress, glycolysis metabolism, calcium ion binding and other biological functions. In conclusion, MC-RR damaged the testes and was toxic to the reproductive system of male zebrafish mainly through causing oxidative stress
So Tom has turned a poet, what a dear [first line]
No full textstrophicnasame as Box 192 Item 50Cover is duplicated in 192.050.
Music is duplicated in 192.050.Johns Hopkins University, Levy Sheet Music Collection, Box
192, Item 051Thomas M-rr-s, Author of "How They Act in Baltimore." "Mephistophiles K.G.S.
So Tom has turned a poet, what a dear [first line]
No full textstrophicnasame as Box 192 Item 50Cover is duplicated in 192.050.
Music is duplicated in 192.050.Johns Hopkins University, Levy Sheet Music Collection, Box
192, Item 051Thomas M-rr-s, Author of "How They Act in Baltimore." "Mephistophiles K.G.S.
So Tom has turned a poet, what a dear [first line]
No full textstrophicnaCover is duplicated in 192.051.
Music is duplicated in 192.051.Johns Hopkins University, Levy Sheet Music Collection, Box
192, Item 050Thomas M-rr-s, Author of "How They Act in Baltimore." "Mephistophiles K.G.S.
So Tom has turned a poet, what a dear [first line]
No full textstrophicnaCover is duplicated in 192.051.
Music is duplicated in 192.051.Johns Hopkins University, Levy Sheet Music Collection, Box
192, Item 050Thomas M-rr-s, Author of "How They Act in Baltimore." "Mephistophiles K.G.S.
FPGA-accelerated calculation of the correlation integral of RR intervals
No full textAnaliza sygnałów biomedycznych jest jednym z ważniejszych obszarów badań naukowych. Istnieje duże zapotrzebowanie na wydajne systemy obliczeniowe, które pozwalały by na analizę sygnałów biomedycznych wielu pacjentów. W artykule przedstawiono propozycję architektury systemu obliczającego całkę korelacji interwałów międzyuderzeniowych RR, wykorzystującego układ FPGA do akceleracji obliczeń.Biomedical signal analysis is a very important field of research. This paper describes architecture of FPGA-accelerated computational system proposed by Author. The main purpose of this system is calculation of the correlation integral of RR intervals in cardiological patients
Patologie respiratorie tra i bambini in eta’ prescolare : analisi geografica del primo ricovero, Pisa, 1998-2004
No full textObiettivo. Evidenziare la eventuale presenza di cluster spaziale di casi per patologie respiratorie tra i bambini in eta prescolare, residenti a Pisa negli anni 1998-2004. L’analisi presentata costituisce il primo stadio di uno studio piu ampio che vuole esaminare l’eventuale associazione tra l’insorgenza di patologie respiratorie nei bambini e la residenza in strade o zone con elevati livelli di inquinamento dell’aria. Metodi. I dati provengono dal Sistema Epidemiologico Integrato (SEI), realizzato a Pisa, che include dati anagrafici, sanitari, ambientali georeferenziati. I casi sono costituiti dai bambini di eta compresa tra i 7 giorni (per escludere i ricoveri per patologie perinatali) e i 1825 giorni (5 anni). Successivamente e stato selezionato il primo ricovero che presentava come diagnosi principale una patologia respiratoria. Per ogni caso sono stati selezionati 5 controlli appaiati per sesso, classe di eta e stesso anno di ricovero. I controlli sono stati selezionati tra i bambini residenti mai ricoverati. Cause esaminate (ICD.9): “Malattie dell’apparato respiratorio” (460-519), “Sintomi relativi all’apparato respiratorio ed altri sintomi toracici”, (786) escludendo le “Altre malattie dell’apparato respiratorio” (470-478) e la “Influenza”. (487). Per la individuazione dei cluster e stato utilizzato il metodo SaTScan, di Kulldorff (1997) su tutto il territorio del Comune di Pisa, le analisi sono state condotte anche per sesso e per due classi di eta’(0-2 e 3-5 anni) Risultati. Il dataset dell’analisi e costituito da 535 casi e 2675 controlli. 396 casi sono sotto i due anni di eta e 139 sono maschi. Il tasso di incidenza del primo ricovero per patologia respiratoria decresce negli anni in tutte le Circoscrizioni, ma nella Circoscrizione 1 (litorale pisano) risulta sempre piu alto rispetto alle altre, nonostante l’andamento della popolazione sia leggermente decrescente. Sono stati identificati i seguenti cluster significativi: Ospedaletto, zona industriale a sud-ovest di Pisa (n. casi 6; RR=6,09; P=0,075; maschi 0-3 anni) e Gagno, nord di Pisa (n. casi 11; RR=4,538; P=0,037; maschi 0-3 anni); Coltano zona agricola a sud di Pisa (n. casi 8; RR=6,314; P=0,007; femmine 0-3 anni); Tirrenia, litorale pisano (n. casi 8; RR=6,076; P=0,009; maschi + femmine di 3-5 anni).Sono stati esplorati gli aspetti socio-economici dei cluster identificati, utilizzando i dati ISTAT, con le sezioni di censimento al 2001. Rispetto ai valori medi di Pisa, le aree dei cluster presentano una popolazione con alta % di persone con bassa istruzione, di disoccupati, di famiglie unigenitoriali con figli dipendenti. Coltano e Tirrenia presentano un alto numero di persone per stanza e maggiori mq/ persona (abitazioni datate, con grandi stanze occupate da molte persone). Infine i modelli di diffusione degli inquinanti provenienti dal polo industriale di Livorno, prodotti dall’ARPAT mostrano una diffusione alquanto suggestiva degli inquinanti proprio sulla zona a sud del comune che include anche il litorale. Conclusioni. E’ la prima volta che viene condotto uno studio di questo genere basato sui sistemi elettronici integrati di flussi sanitari e demografici di cui e’ stata completata anche la validazione di qualita. I cluster significativi sono stati individuati nelle zone periferiche mentre nel centro urbano la distribuzione dei ricoveri risulta omogenea, verosimilmente a causa della elevata densita’ di popolazione e la omogenea esposizione ad inquinanti; occorrera quindi effettuare una analisi piu’ mirata. Dovra essere approfondito sia il ruolo di confondimento giocato dai fattori socio-economici sia il ruolo degli andamenti giornalieri degli inquinanti provenienti dal polo di Livorno. I risultati sono interessanti e promettenti, in quanto offrono validi spunti per ulteriori approfondimenti in particolar modo di tipo ambientale
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Modes, masses, metallicities, and magnitudes of RR Lyrae variables
No full textThe author reviews past and recent developments in the study of RR Lyrae variables. He provides supporting evidence for a large helium content but remains uncertain as to their masses and luminosities. Time dependent convection is offered as a probable explanation for the double mode pulsations of these stars. 25 refs., 8 figs., 3 tabs
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