1,721,002 research outputs found
Vascular dysfunction and inflammation in laminitis: modifying blood flow through the equine digit
No full textThis is a guest editorial commenting on a paper published by Mitchell and coworkers (Vet J. 2010 Oct;186(1):106-9). The editorial presents an overview of the current knowledge about the crucial role that the digital vasculature plays in the onset of equine laminitis
Atrial fibrillation in horse:difficult diagnosis for a therapeutic orphan
No full textIt is generally acknowledged that atrial fibrillation (AF) is a common pathological arrhythmia in horses There is currently a debate to ascertain whether equine AF can occur per se or whether it is the consequence of cardiac pathologies. In the fist case, reversion to normal rhythm can be successfully achieved by medical cardioversion but, in the former, conversion to sinus rhythm is less successful and recurrence of AF is more common.
A new generation of cardioverter-defibrillators is now available and may offer an alternative approach to pharmacological cardioversion in animals. However quinidine sulphate remains the only real therapeutic option for AF in horses despite the serious adverse effects may be associated with the treatment. The use of flecainide proved to be of limited value whereas amiodarone has shown encouraging results.
The practitioner is often hesitant in using pharmacological cardioversion, as the therapeutic choice is limited and the risk related to the treatment is quite high. An equine experimental model of chronic AF has been proposed. By applying it to integrated pharmacodynamic/pharmacokinetic (PK/PD) or physiologically based pharmacokinetic (PBPK) models it could represent the most practicable approach for targeting safe and effective drug dosage regimens to expand the therapeutic opportunities for treating AF successfully in the horse
Expression of calprotectin subunits (S100A8 and S100A9) in equine recurrent airway obstruction
No full textThis study provides the first evidence that a soluble form of the
CP subunit S100A9 is released in the airways of asymptomatic
RAO horses and undergoes up-regulation during clinical exacerbation
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Comparative pharmacokinetics of ampicillin-sulbactam combination in calves and sheep.
No full textThe pharmacokinetics of ampicillin and sulbactam administered in combination were studied in calves and sheep. The animals were administered an aqueous solution of ampicillin/sulbactam (2:1, w/w) intravenously and intramuscularly at doses of 13.2 and 6.6 mg.kg-1, respectively. A microbiological method was used to detect ampicillin, and HPLC was used to detect sulbactam in serum. Following intravenous (i.v.) administration, the distribution phases were rapid and similar (about 15 min) for both drugs in both species, whereas sulbactam in calves and ampicillin in sheep showed a faster elimination rate. After intramuscular (i.m.) administration both drugs showed peak concentrations higher in calves than in sheep; the peak time of sulbactam was shorter in calves than in sheep. No other significant differences in the pharmacokinetics of the combination were observed between the species after i.m. injection. The mean residence and absorption times, calculated by non-compartmental analysis, for both calves and sheep suggested that the differences in ampicillin and sulbactam pharmacokinetics could be attributable to the different molecular structure
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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